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2-METHOXYESTRADIOL Drug Record

  • Summary
  • Interactions
  • Claims
  • 2-METHOXYESTRADIOL chembl:CHEMBL299613 Antineoplastic

    Alternate Names:

    NSC-659853
    2-METHOXYESTRADIOL

    Drug Info:

    (1 More Sources)

    Publications:

    Muh et al., 2014, PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression., J. Neurooncol.
    Lewis et al., 2005, Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells., J. Mol. Endocrinol.
    Rimon et al., 2008, Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor., Endocrinology
    Bogatcheva et al., 2007, Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction., Am. J. Physiol. Lung Cell Mol. Physiol.
    Attalla et al., 1998, 2-Methoxyestradiol-induced phosphorylation of Bcl-2: uncoupling from JNK/SAPK activation., Biochem. Biophys. Res. Commun.
  • 2-METHOXYESTRADIOL   ATF2

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15691880


    Sources:
    NCI

  • 2-METHOXYESTRADIOL   SETD2

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • 2-METHOXYESTRADIOL   CCN2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18292194


    Sources:
    NCI

  • 2-METHOXYESTRADIOL   MAPK8

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9647742


    Sources:
    NCI

  • 2-METHOXYESTRADIOL   MAPK14

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17012370


    Sources:
    NCI

  • 2-METHOXYESTRADIOL   PTEN

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type glioblastoma multiforme
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    24162827


    Sources:
    JAX-CKB

  • 2-METHOXYESTRADIOL   GLP1R

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 2-METHOXYESTRADIOL   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 2-METHOXYESTRADIOL   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 2-METHOXYESTRADIOL   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: 2-METHOXYESTRADIOL

    • Version: 14-September-2017

    Alternate Names:
    C965 NCI drug code

    Drug Info:

    Publications:
    Attalla et al., 1998, 2-Methoxyestradiol-induced phosphorylation of Bcl-2: uncoupling from JNK/SAPK activation., Biochem. Biophys. Res. Commun.
    Bogatcheva et al., 2007, Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction., Am. J. Physiol. Lung Cell Mol. Physiol.
    Lewis et al., 2005, Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells., J. Mol. Endocrinol.

  • JAX-CKB: 2-Methoxyestradiol

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Muh et al., 2014, PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression., J. Neurooncol.

  • DTC: 2-METHOXYESTRADIOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL299613 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: 2-Methoxyestradiol

    • Version: 2020.06.01

    Alternate Names:
    D06NYA TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL299613

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21