• Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction FlexStation 2 Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging, patch clamp
    Specific Action of the Ligand Activation
    Details of Interaction Apomorphine blocks TRPA1 at 100µM

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Details of Interaction This compound also activates mouse TRPA1

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Details of Interaction This compound also activates mouse TRPA1

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Sodium and calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Details of Interaction This compound also activates mouse TRPA1

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Details of Interaction This compound is also an activator of mouse TRPA1.

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging, patch clamp
    Specific Action of the Ligand Activation
    Details of Interaction This compound has similar activity at mouse and rat TRPA1

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Details of Interaction This compound also activates mouse TRPA1

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Patch clamp
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Patch clamp
    Specific Action of the Ligand Activation
    Details of Interaction non-covalent

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction FLIPR calcium influx assay
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Patch clamp
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Details of Interaction This compound has similar activity at rat and mouse TRPA1

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction FLIPR calcium-influx assay
    Specific Action of the Ligand Activation
    Endogenous Drug? True

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction FLIPR calcium influx assay
    Specific Action of the Ligand Activation
    Details of Interaction non-covalent

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Specific Action of the Ligand Agonist
    Details of Interaction covalent
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Specific Action of the Ligand Agonist
    Details of Interaction covalent
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Details of the Assay for Interaction Fluorometric Imaging Plate Reader (FLIRP) calcium-influx assay
    Specific Action of the Ligand Agonist
    Details of Interaction non-covalent

    Publications:

  • Interaction Types:
    gating inhibitor

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Inhibition
    Details of Interaction This compoud also acts as a gating inhibitor at the rat and mouse TRPA1.

    Publications:

  • Interaction Types:
    gating inhibitor

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Transient receptor potential cation channel subfamily A member 1 antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Transient receptor potential cation channel subfamily A member 1 antagonist
    Direct Interaction yes

    Publications:

    • Version: 90_38

    Alternate Names:
    TRPA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000104321 Ensembl Gene Id
    O75762 Uniprot Accession
    TRPA1 Gene Symbol

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass Channels
    Target Main Class Transporters

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000104321 Ensembl Gene Id
    TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY A MEMBER 1 (ANKYRIN-LIKE WITH TRANSMEMBRANE DOMAINS PROTEIN 1) (TRANSFORMATION SENSITIVE-PROTEIN P120). [SOURCE:UNIPROT/SWISSPROT;ACC:O75762] Description
    TRPA1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: February-2014

    Alternate Names:
    8989 Entrez Gene ID

    Gene Info:
    Initial Gene Query TRPA1
    Counted Citations from 1950-2000 455
    Gene Category Ion Channel

    Publications:

    • Version: January-2014

    Alternate Names:
    TRPA1 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.4.6.3

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    transient receptor potential cation channel, subfamily A, member 1 HUGO Gene Name
    497 HUGO Gene ID
    TRPA1 Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Transient Receptor Potential channels
    GuideToPharmacology Gene Category ID 78
    GuideToPharmacology Gene Type vgic

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    8989 Entrez Gene Id
    TRPA1_HUMAN Uniprot Id
    ENSG00000104321 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR005821
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Publications:

    • Version: 5.0.8
    • Version: 27-September-2017

    Alternate Names:
    TRPA1 GuideToPharmacology Name
    O75762 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY A MEMBER 1 Gene Name
    ENSG00000104321 Ensembl Gene Id
    ANKYRIN-LIKE WITH TRANSMEMBRANE DOMAINS PROTEIN 1 Gene Synonym

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000104321 Gene Symbol
    TRPA1 Ensembl Id

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    ANKTM1 GENE_SYMBOL
    TRPA1 GENE_SYMBOL
    Transient receptor potential cation channel subfamily A member 1 UNIPROT

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    O75762 UniProtKB ID
    TRPA1_HUMAN GO Gene Synonym
    ANKTM1 GO Gene Synonym

    Gene Info:

    Publications: