• TOP1MT 116447 Druggable Genome

    Alternate Names:

    116447
    DNA TOPOISOMERASE I MITOCHONDRIAL
    TOP1MT
    606387
    29787
    ENSG00000184428
    OTTHUMG00000164979
    DNA topoisomerase I, mitochondrial
    DNA TOPOISOMERASE I, MITOCHONDRIAL PRECURSOR (EC 5.99.1.2) (TOP1MT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q969P6]
    Q969P6
    TOP1M_HUMAN
    BE0000091

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Short Name TopoI
    Interpro Acc IPR001631
    Interpro Name DNA topoisomerase I
    Uniprot Evidence 2: Evidence at transcript level
    Uniprot Status Swiss-Prot
    Target Subclass 5.99.1.2
    Target Main Class Enzymes
    Gene Biotype PROTEIN_CODING"
    Target Class Enzymes
    Target Subclass EC:5.99.1.2
    (4 More Sources)

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase I, mitochondrial inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name CPX-1
    Novel drug target Established target
    Trial Name PEP-02

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name LE-SN38
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications: