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TNFRSF10A Gene Record

categories for TNFRSF10A
  • Summary
  • Interactions
  • Claims
  • TNFRSF10A 8797 Druggable Genome

    Alternate Names:

    8797
    TNF RECEPTOR SUPERFAMILY MEMBER 10A
    TNFRSF10A
    APO2
    CD261
    DR4
    TRAILR-1
    TRAILR1
    603611
    11904
    ENSG00000104689
    OTTHUMG00000097843
    TRAIL-R1
    TRAIL receptor 1
    CD_antigen=CD261
    TNF-related apoptosis-inducing ligand receptor 1
    Death receptor 4
    Tumor necrosis factor receptor superfamily member 10A
    TRAIL-R1/DR4,R2/D5
    TRAIL-R1/D4
    TTDC00267
    O00220
    1879
    TR10A_HUMAN

    Gene Info:

    Target Class Receptors
    Target Subclass Receptors
    Target Subclass TNFNGF
    Gene Biotype PROTEIN_CODING"
    (6 More Sources)

    Publications:

    Choi et al., 2008, Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress., Pharm. Res.
    Koornstra et al., 2005, Sulindac inhibits beta-catenin expression in normal-appearing colon of hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis patients., Cancer Epidemiol. Biomarkers Prev.
  • CHEMBL1790415   TNFRSF10A

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • MAPATUMUMAB   TNFRSF10A

    Interaction Types:
    agonist
    antibody

    Interaction Info:
    Trial Name HGS-ETR1
    Novel drug target Novel Target
    Notes

    Publications:

  • DULANERMIN   TNFRSF10A

    Interaction Types:
    agonist
    antibody

    Interaction Info:
    Mechanism of Interaction TRAIL receptor-1 agonist
    Direct Interaction yes

    Publications:

  • HYDROGEN PEROXIDE   TNFRSF10A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Choi et al., 2008, Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress., Pharm. Res.

  • SULINDAC   TNFRSF10A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Koornstra et al., 2005, Sulindac inhibits beta-catenin expression in normal-appearing colon of hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis patients., Cancer Epidemiol. Biomarkers Prev.

  • Ensembl: ENSG00000104689

    • Version: 90_38

    Alternate Names:
    TNFRSF10A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

  • TdgClinicalTrial: O00220

    • Version: January-2014

    Alternate Names:
    TNFRSF10A Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass TNFNGF

    Publications:

  • NCI: TNFRSF10A

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Rokhlin et al., TRAIL-DISC formation is androgen-dependent in the human prostatic carcinoma cell line LNCaP., Cancer Biol. Ther.
    Choi et al., 2008, Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress., Pharm. Res.
    Koornstra et al., 2005, Sulindac inhibits beta-catenin expression in normal-appearing colon of hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis patients., Cancer Epidemiol. Biomarkers Prev.

  • GuideToPharmacologyInteractions: 1879

    • Version: 27-September-2017

    Alternate Names:
    death receptor 4 GuideToPharmacology Name
    O00220 UniProtKB ID

    Gene Info:

    Publications:

  • MyCancerGenome: TNFRSF10A

    • Version: 20-Jun-2017

    Alternate Names:
    8797 Entrez Gene Id
    TNFRSF10A MyCancerGenome Gene Symbol
    TRAIL-R1/DR4,R2/D5 MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • GO: TNFRSF10A

    • Version: 27-September-2017

    Alternate Names:
    O00220 UniProtKB ID
    TR10A_HUMAN GO Gene Synonym
    APO2 GO Gene Synonym

    Gene Info:

    Publications:

  • TTD: TTDC00267

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR 1 Gene Synonym
    TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A Gene Name
    8797 Entrez Gene Id

    Gene Info:

    Publications:

  • TALC: TRAIL-R1

    • Version: 12-May-2016

    Alternate Names:
    TRAIL-R1 Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000104689

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000104689 Gene Symbol
    TNFRSF10A Ensembl Id

    Gene Info:

    Publications:

  • ChemblInteractions: APO2

    • Version: chembl_23

    Alternate Names:
    DR4 GENE_SYMBOL
    TRAILR1 GENE_SYMBOL
    TNFRSF10A GENE_SYMBOL

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25