TEK Gene Record

categories for TEK

  • TEK 7010 Druggable Genome

    Alternate Names:

    7010
    TEK RECEPTOR TYROSINE KINASE
    TEK
    CD202B
    GLC3E
    TIE-2
    TIE2
    VMCM
    VMCM1
    600221
    11724
    ENSG00000120156
    OTTHUMG00000019712
    Tyrosine-protein kinase receptor TIE-2
    p140 TEK
    CD_antigen=CD202b
    hTIE2
    Angiopoietin-1 receptor
    Tyrosine-protein kinase receptor TEK
    Endothelial tyrosine kinase
    Tunica interna endothelial cell kinase
    Tyrosine kinase with Ig and EGF homology domains-2
    ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763]
    Q02763
    BE0003379
    TTDC00161
    CD202B ANTIGEN
    ANGIOPOIETIN 1 RECEPTOR
    ENDOTHELIAL CELL-SPECIFIC RECEPTOR TIE-2
    1842
    TIE2_HUMAN
    TEK tyrosine kinase, endothelial
    NM_000459
    NP_000450

    Gene Info:

    Human Readable Name TYROSINE KINASE
    Human Readable Name DRUGGABLE GENOME
    Target Subclass EC:2.7.10.1
    Target Class Receptors
    Gene Biotype PROTEIN_CODING"
    Human Readable Name KINASE
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001245
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    GuideToPharmacology Gene Category Name Type XII RTKs: TIE family of angiopoietin receptors
    GuideToPharmacology Gene Category ID 330
    GuideToPharmacology Gene Type catalytic_receptor
    (12 More Sources)

    Publications:

  • VANDETANIB   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • REGORAFENIB   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • ALTIRATINIB   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • CEP-11981   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • TICARCILLIN   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • LINIFANIB   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • MGCD-265   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name MGCD265
    Novel drug target Novel Target
    Notes

    Publications:

  • Pexmetinib   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes
    Trial Name ARRY-614

    Publications:

  • FORETINIB   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • CE-245677   TEK

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • PONATINIB   TEK

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • CEP-7055   TEK

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • POLYMYXIN B   TEK

    Interaction Types:
    n/a

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? True

    Publications:

  • CHEMBL245549   TEK

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • CABOZANTINIB   TEK

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • Ensembl: ENSG00000120156

    • Version: 90_38

    Alternate Names:
    TEK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

  • dGene: 7010

    • Version: 27-June-2013

    Alternate Names:
    7010 Entrez Gene Id
    TEK Gene Symbol

    Gene Info:
    Human Readable Name TYROSINE KINASE

    Publications:

  • GuideToPharmacologyGenes: 1842

    • Version: 4-March-2015

    Alternate Names:
    TEK tyrosine kinase, endothelial HUGO Gene Name
    11724 HUGO Gene ID
    TEK Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Type XII RTKs: TIE family of angiopoietin receptors
    GuideToPharmacology Gene Category ID 330
    GuideToPharmacology Gene Type catalytic_receptor

    Publications:

  • HopkinsGroom: Q02763

    • Version: 11-September-2012

    Alternate Names:
    7010 Entrez Gene Id
    Q02763 Uniprot Accession
    TEK Uniprot Gene Name

    Gene Info:
    Human Readable Name KINASE
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level

    Publications:

  • RussLampel: ENSG00000120156

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000120156 Ensembl Gene Id
    TEK Display Id
    ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q02763

    • Version: January-2014

    Alternate Names:
    TIE2 Gene Symbol
    TEK Gene Symbol

    Gene Info:
    Target Subclass EC:2.7.10.1
    Target Class Receptors

    Publications:

  • DrugBank: BE0003379

    • Version: 5.0.8

    Alternate Names:
    TEK DrugBank Gene Name
    Q02763 UniProt Accession
    7010 Entrez Gene Id

    Gene Info:

    Publications:
    Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • GuideToPharmacologyInteractions: 1842

    • Version: 27-September-2017

    Alternate Names:
    TEK receptor tyrosine kinase GuideToPharmacology Name
    Q02763 UniProtKB ID

    Gene Info:

    Publications:

  • TALC: TIE2

    • Version: 12-May-2016

    Alternate Names:
    TIE2 Gene Symbol

    Gene Info:

    Publications:

  • TTD: TTDC00161

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    TYROSINE-PROTEIN KINASE RECEPTOR TIE-2 Gene Synonym
    ENDOTHELIAL CELL-SPECIFIC RECEPTOR TIE-2 Gene Synonym
    Q02763 Uniprot Accession

    Gene Info:

    Publications:

  • TALC: TIE-2

    • Version: 12-May-2016

    Alternate Names:
    TIE-2 Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000120156

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000120156 Gene Symbol
    TEK Ensembl Id

    Gene Info:

    Publications:

  • GO: TEK

    • Version: 27-September-2017

    Alternate Names:
    Q02763 UniProtKB ID
    TIE2_HUMAN GO Gene Synonym
    TIE2 GO Gene Synonym

    Gene Info:

    Publications:

  • ChemblInteractions: TIE2

    • Version: chembl_23

    Alternate Names:
    VMCM GENE_SYMBOL
    VMCM1 GENE_SYMBOL
    TEK GENE_SYMBOL

    Gene Info:

    Publications:

  • MyCancerGenomeClinicalTrial: TEK

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • ClearityFoundationClinicalTrial: TEK

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications: