• TEK 7010 Druggable Genome

    Alternate Names:

    7010
    TEK RECEPTOR TYROSINE KINASE
    TEK
    CD202B
    GLC3E
    TIE-2
    TIE2
    VMCM
    VMCM1
    600221
    11724
    ENSG00000120156
    OTTHUMG00000019712
    Tyrosine-protein kinase receptor TIE-2
    p140 TEK
    CD_antigen=CD202b
    hTIE2
    Angiopoietin-1 receptor
    Tyrosine-protein kinase receptor TEK
    Endothelial tyrosine kinase
    Tunica interna endothelial cell kinase
    Tyrosine kinase with Ig and EGF homology domains-2
    ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763]
    Q02763
    BE0003379
    TTDC00161
    CD202B ANTIGEN
    ANGIOPOIETIN 1 RECEPTOR
    ENDOTHELIAL CELL-SPECIFIC RECEPTOR TIE-2
    1842
    TIE2_HUMAN
    TEK tyrosine kinase, endothelial
    NM_000459
    NP_000450

    Gene Info:

    Human Readable Name TYROSINE KINASE
    Human Readable Name DRUGGABLE GENOME
    Target Subclass EC:2.7.10.1
    Target Class Receptors
    Gene Biotype PROTEIN_CODING"
    Human Readable Name KINASE
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001245
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    GuideToPharmacology Gene Category Name Type XII RTKs: TIE family of angiopoietin receptors
    GuideToPharmacology Gene Category ID 330
    GuideToPharmacology Gene Type catalytic_receptor
    (12 More Sources)
  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name MGCD265
    Novel drug target Novel Target
    Notes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes
    Trial Name ARRY-614

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? True

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications:

    • Version: 90_38

    Alternate Names:
    TEK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 27-June-2013

    Alternate Names:
    7010 Entrez Gene Id
    TEK Gene Symbol

    Gene Info:
    Human Readable Name TYROSINE KINASE

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    TEK tyrosine kinase, endothelial HUGO Gene Name
    11724 HUGO Gene ID
    TEK Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Type XII RTKs: TIE family of angiopoietin receptors
    GuideToPharmacology Gene Category ID 330
    GuideToPharmacology Gene Type catalytic_receptor

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    7010 Entrez Gene Id
    Q02763 Uniprot Accession
    TEK Uniprot Gene Name

    Gene Info:
    Human Readable Name KINASE
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000120156 Ensembl Gene Id
    TEK Display Id
    ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    TIE2 Gene Symbol
    TEK Gene Symbol

    Gene Info:
    Target Subclass EC:2.7.10.1
    Target Class Receptors

    Publications:

    • Version: 5.0.8
    • Version: 27-September-2017

    Alternate Names:
    TEK receptor tyrosine kinase GuideToPharmacology Name
    Q02763 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 12-May-2016

    Alternate Names:
    TIE2 Gene Symbol

    Gene Info:

    Publications:

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    TYROSINE-PROTEIN KINASE RECEPTOR TIE-2 Gene Synonym
    ENDOTHELIAL CELL-SPECIFIC RECEPTOR TIE-2 Gene Synonym
    Q02763 Uniprot Accession

    Gene Info:

    Publications:

    • Version: 12-May-2016

    Alternate Names:
    TIE-2 Gene Symbol

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000120156 Gene Symbol
    TEK Ensembl Id

    Gene Info:

    Publications:

  • GO: TEK

    • Version: 27-September-2017

    Alternate Names:
    Q02763 UniProtKB ID
    TIE2_HUMAN GO Gene Synonym
    TIE2 GO Gene Synonym

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    VMCM GENE_SYMBOL
    VMCM1 GENE_SYMBOL
    TEK GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications: