• SCN8A 6334 Druggable Genome

    Alternate Names:

    6334
    SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 8
    SCN8A
    BFIS5
    CERIII
    CIAT
    EIEE13
    MED
    NaCh6
    Nav1.6
    PN4
    600702
    10596
    ENSG00000196876
    OTTHUMG00000169490
    Q9UQD0
    SODIUM CHANNEL PROTEIN TYPE VIII ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.6). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UQD0]
    SCN8A_HUMAN
    SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA
    Sodium channel protein type VIII subunit alpha
    Voltage-gated sodium channel subunit alpha Nav1.6
    583
    NP_055006
    Na<sub>v</sub>1.6
    NM_014191
    sodium channel, voltage gated, type VIII, alpha subunit
    BE0002084

    Gene Info:

    Initial Gene Query Nav1.6
    Counted Citations from 1950-2000 277
    Gene Category Ion Channel
    Target Class Transporters
    Target Subclass TC:1.A.1.10.8
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Ion transport domain
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name ION CHANNEL
    Interpro Short Name Ion_trans_dom
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR005821
    GuideToPharmacology Gene Category Name Voltage-gated sodium channels
    GuideToPharmacology Gene Category ID 82
    GuideToPharmacology Gene Type vgic
    Gene Biotype PROTEIN_CODING"
    (7 More Sources)
  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand Pore blocker
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    gating inhibitor

    Interaction Info:
    Specific Action of the Ligand Slows inactivation
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name tetrodotoxin,Tectin, Tetrodin
    Novel drug target Established target

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name Safinamide
    Novel drug target Established target

    Publications:

    • Version: 90_38

    Alternate Names:
    SCN8A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: February-2014

    Alternate Names:
    6334 Entrez Gene ID

    Gene Info:
    Initial Gene Query Nav1.6
    Counted Citations from 1950-2000 277
    Gene Category Ion Channel

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    Q9UQD0 Uniprot Accession
    SCN8A_HUMAN Uniprot Id
    SCN8A Uniprot Gene Name

    Gene Info:
    Interpro Name Ion transport domain
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    SCN8A Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.10.8

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    6334 Entrez Gene ID
    Q9UQD0 SwissProt Accession
    NP_055006 RefSeq Protein Accession

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated sodium channels
    GuideToPharmacology Gene Category ID 82
    GuideToPharmacology Gene Type vgic

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    SODIUM CHANNEL PROTEIN TYPE VIII ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.6). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UQD0] Description
    SCN8A Display Id
    ENSG00000196876 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 5.0.8

    Alternate Names:
    ENSG00000196876 Ensembl Gene Id
    6334 Entrez Gene Id
    Q9UQD0 UniProt Accession

    Gene Info:

    • Version: 27-September-2017

    Alternate Names:
    Q9UQD0 UniProtKB ID
    Na<sub>v</sub>1.6 GuideToPharmacology Name

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    SCN8A Ensembl Id
    ENSG00000196876 Gene Symbol

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    Voltage-gated sodium channel subunit alpha Nav1.6 UNIPROT
    Sodium channel protein type VIII subunit alpha UNIPROT
    Sodium channel protein type 8 subunit alpha UNIPROT

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    MED GO Gene Synonym
    SCN8A_HUMAN GO Gene Synonym
    Q9UQD0 UniProtKB ID

    Gene Info:

    Publications: