• RYR2 6262 Druggable Genome

    Alternate Names:

    6262
    RYANODINE RECEPTOR 2
    RYR2
    ARVC2
    ARVD2
    RYR-2
    RyR
    VTSIP
    180902
    10484
    ENSG00000198626
    OTTHUMG00000039543
    TTDS00165
    RYANODINE RECEPTOR
    Q92736
    SKELETAL MUSCLE CALCIUM RELEASE CHANNEL
    CARDIAC MUSCLE RYANODINE RECEPTOR-CALCIUM RELEASE CHANNEL
    BRAIN RYANODINE RECEPTOR-CALCIUM RELEASE CHANNEL
    CARDIAC MUSCLE-TYPE RYANODINE RECEPTOR
    SKELETAL MUSCLE-TYPE RYANODINE RECEPTOR
    BRAIN-TYPE RYANODINE RECEPTOR
    748
    ryanodine receptor 2 (cardiac)
    PA300
    RYR2_HUMAN
    RYANODINE RECEPTOR 2 (CARDIAC MUSCLE-TYPE RYANODINE RECEPTOR) (RYR2) (RYR-2) (CARDIAC MUSCLE RYANODINE RECEPTOR-CALCIUM RELEASE CHANNEL) (HRYR-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92736]
    BE0005295

    Gene Info:

    GuideToPharmacology Gene Category Name Ryanodine receptor
    GuideToPharmacology Gene Category ID 125
    GuideToPharmacology Gene Type lgic
    Has Variant Annotation true
    Is VIP false
    Human Readable Name DRUGGABLE GENOME
    Interpro Name B30.2/SPRY domain
    Interpro Short Name B30.2/SPRY
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Short Name Ion_trans_dom
    Interpro Name Ion transport domain
    Human Readable Name ION CHANNEL
    Interpro Acc IPR001870
    Human Readable Name B30_2 SPRY DOMAIN
    Interpro Acc IPR005821
    Gene Biotype PROTEIN_CODING"
    Initial Gene Query RyR2
    Counted Citations from 1950-2000 662
    Gene Category Ion Channel
    (7 More Sources)

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Interaction Context cytosolic
    Specific Action of the Ligand None
    Details of Interaction endogenous; mM range

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction pharmacological; mM range
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist
    activator

    Interaction Info:
    Interaction Context cytosolic
    Specific Action of the Ligand None
    Details of Interaction endogenous; μM range

    Publications:

  • Interaction Types:
    activator
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction pharmacological; nM - μM range
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction pharmacological; μM range
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Interaction Context cytosolic
    Specific Action of the Ligand Antagonist
    Details of Interaction mM range

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications: