• RYR1 6261 Druggable Genome

    Alternate Names:

    6261
    RYANODINE RECEPTOR 1
    RYR1
    CCO
    MHS
    MHS1
    PPP1R137
    RYDR
    RYR
    RYR-1
    SKRR
    180901
    10483
    ENSG00000196218
    OTTHUMG00000182403
    P21817
    RYR1_HUMAN
    Skeletal muscle ryanodine receptor
    Skeletal muscle-type ryanodine receptor
    Type 1 ryanodine receptor
    Skeletal muscle calcium release channel
    747
    ryanodine receptor 1 (skeletal)
    BE0000739
    RYANODINE RECEPTOR 1 (SKELETAL MUSCLE-TYPE RYANODINE RECEPTOR) (RYR1) (RYR-1) (SKELETAL MUSCLE CALCIUM RELEASE CHANNEL). [SOURCE:UNIPROT/SWISSPROT;ACC:P21817]

    Gene Info:

    Interpro Acc IPR005821
    Interpro Acc IPR001870
    Human Readable Name B30_2 SPRY DOMAIN
    Interpro Name B30.2/SPRY domain
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Human Readable Name ION CHANNEL
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name B30.2/SPRY
    Interpro Short Name Ion_trans_dom
    Interpro Name Ion transport domain
    GuideToPharmacology Gene Category Name Ryanodine receptor
    GuideToPharmacology Gene Category ID 125
    GuideToPharmacology Gene Type lgic
    Target Class Transporters
    Target Subclass TC:1.A.3.1.2
    Target Subclass RYR_ITPR
    Target Subclass Channels
    Target Subclass Voltage_gated_ion_channels
    Target Main Class Transporters
    Transmembrane Helix Count 9
    Initial Gene Query RyR1
    Counted Citations from 1950-2000 807
    Gene Category Ion Channel
    Gene Biotype PROTEIN_CODING"
    (8 More Sources)
  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Ryanodine receptor 1 antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Interaction Context cytosolic
    Specific Action of the Ligand None
    Details of Interaction endogenous; mM range

    Publications:

  • Interaction Types:
    activator

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction pharmacological; mM range
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist
    activator

    Interaction Info:
    Interaction Context luminal
    Specific Action of the Ligand None
    Details of Interaction endogenous

    Publications:

  • Interaction Types:
    activator
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction pharmacological; nM - μM range
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Interaction Context cytosolic
    Specific Action of the Ligand Antagonist
    Details of Interaction mM range

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    agonist
    activator

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction pharmacological; μM range
    Endogenous Drug? False

    • Version: 90_38

    Alternate Names:
    RYR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    ryanodine receptor 1 (skeletal) HUGO Gene Name
    10483 HUGO Gene ID
    RYR1 Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Ryanodine receptor
    GuideToPharmacology Gene Category ID 125
    GuideToPharmacology Gene Type lgic

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000196218 Ensembl Gene Id
    RYR1 Display Id
    RYANODINE RECEPTOR 1 (SKELETAL MUSCLE-TYPE RYANODINE RECEPTOR) (RYR1) (RYR-1) (SKELETAL MUSCLE CALCIUM RELEASE CHANNEL). [SOURCE:UNIPROT/SWISSPROT;ACC:P21817] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: February-2014

    Alternate Names:
    6261 Entrez Gene ID

    Gene Info:
    Initial Gene Query RyR1
    Counted Citations from 1950-2000 807
    Gene Category Ion Channel

    Publications:

    • Version: January-2014

    Alternate Names:
    RYR1 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.3.1.2

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    RYR1_HUMAN Uniprot Id
    ENSG00000196218 Ensembl Gene Id
    RYR1 Gene Symbol

    Gene Info:
    Target Subclass RYR_ITPR
    Target Subclass Channels
    Target Subclass Voltage_gated_ion_channels

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    RYANODINE RECEPTOR 1 Uniprot Protein Name
    RYR1_HUMAN Uniprot Id
    P21817 Uniprot Accession

    Gene Info:
    Interpro Acc IPR005821
    Interpro Acc IPR001870
    Human Readable Name B30_2 SPRY DOMAIN

    Publications:

    • Version: 5.0.8
    • Version: 27-September-2017

    Alternate Names:
    RyR1 GuideToPharmacology Name
    P21817 UniProtKB ID

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    RYDR GENE_SYMBOL
    RYR1 GENE_SYMBOL
    Ryanodine receptor 1 UNIPROT

    Gene Info:

    Publications:

  • GO: RYR1

    • Version: 27-September-2017

    Alternate Names:
    P21817 UniProtKB ID
    RYR1_HUMAN GO Gene Synonym
    RYDR GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196218 Gene Symbol
    RYR1 Ensembl Id

    Gene Info:

    Publications: