• PRKDC 5591 Druggable GenomeClinically Actionable

    Alternate Names:

    5591
    PROTEIN KINASE, DNA-ACTIVATED, CATALYTIC POLYPEPTIDE
    PRKDC
    DNA-PKcs
    DNAPK
    DNPK1
    HYRC
    HYRC1
    IMD26
    XRCC7
    p350
    600899
    9413
    ENSG00000253729
    OTTHUMG00000164239
    BE0002385
    P78527
    DNA-dependent protein kinase catalytic subunit
    p460
    DNA-PK catalytic subunit
    PRKDC_HUMAN
    2800
    NP_008835|NP_001075109
    NM_006904|NM_001081640
    ENSG00000121031
    DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (EC 2.7.1.37) (DNA- PKCS) (DNPK1) (P460). [SOURCE:UNIPROT/SWISSPROT;ACC:P78527]

    Gene Info:

    Human Readable Name SERINE THREONINE KINASE
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name PI3/4_kinase_cat_dom
    Human Readable Name PHOSPHATIDYLINOSITOL 3 KINASE
    Interpro Acc IPR000403
    Uniprot Evidence 1: Evidence at protein level
    Source Reported Gene Name PRKDC
    Gene Category CLINICALLY ACTIONABLE
    GuideToPharmacology Gene Category Name Other PIKK family kinases
    GuideToPharmacology Gene Category ID 598
    GuideToPharmacology Gene Type enzyme
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Gene Biotype PROTEIN_CODING"
    (8 More Sources)

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction ELISA measuring the ability of DNA-PK (extracted from HeLa cells) to phosphorylate Ser<sup>15</sup> of a p53 peptide
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction DNA-dependent protein kinase inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name SF1126
    Novel drug target Novel Target

    Publications:

    • Version: 90_38

    Alternate Names:
    PRKDC Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000253729 Ensembl Gene Id
    PRKDC_HUMAN Uniprot Id
    DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT Uniprot Protein Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 27-June-2013

    Alternate Names:
    5591 Entrez Gene Id
    PRKDC Gene Symbol

    Gene Info:
    Human Readable Name SERINE THREONINE KINASE

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    protein kinase, DNA-activated, catalytic polypeptide HUGO Gene Name
    9413 HUGO Gene ID
    PRKDC Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Other PIKK family kinases
    GuideToPharmacology Gene Category ID 598
    GuideToPharmacology Gene Type enzyme

    Publications:

    • Version: January-2014

    Alternate Names:
    PRKDC Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

    • Version: 20-September-2013

    Alternate Names:
    5591 Entrez Gene ID

    Gene Info:
    Source Reported Gene Name PRKDC
    Gene Category CLINICALLY ACTIONABLE

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (EC 2.7.1.37) (DNA- PKCS) (DNPK1) (P460). [SOURCE:UNIPROT/SWISSPROT;ACC:P78527] Description
    PRKDC Display Id
    ENSG00000121031 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 5.0.8
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000253729 Gene Symbol
    PRKDC Ensembl Id

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    DNA-dependent protein kinase catalytic subunit GuideToPharmacology Name
    P78527 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    P78527 UniProtKB ID
    PRKDC_HUMAN GO Gene Synonym
    HYRC GO Gene Synonym

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    HYRC1 GENE_SYMBOL
    PRKDC GENE_SYMBOL
    DNA-dependent protein kinase catalytic subunit UNIPROT

    Gene Info:

    Publications: