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PPARD Gene Record

categories for PPARD
  • Summary
  • Interactions
  • Claims
  • PPARD 5467 Druggable Genome

    Alternate Names:

    5467
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA
    PPARD
    FAAR
    NR1C2
    NUC1
    NUCI
    NUCII
    PPARB
    600409
    9235
    ENSG00000112033
    OTTHUMG00000014567
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA (PPAR-DELTA) (PPAR- BETA) (NUCLEAR HORMONE RECEPTOR 1) (NUC1) (NUCI). [SOURCE:UNIPROT/SWISSPROT;ACC:Q03181]
    BE0001007
    Q03181
    PA33557
    peroxisome proliferator-activated receptor delta
    PPAR-beta
    Nuclear hormone receptor 1
    Nuclear receptor subfamily 1 group C member 2
    Peroxisome proliferator-activated receptor beta
    PPAR-delta
    PPARD_HUMAN
    TTDC00069
    PPARDELTA
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BETA/DELTA
    594
    Peroxisome proliferator-activated receptor-β/δ
    NP_006229
    NM_177435

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query NR1C2
    Counted Citations from 1950-2000 900
    Gene Category Nuclear Hormone Receptors
    Is VIP false
    Has Variant Annotation true
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Target Class Receptors
    Target Subclass Nuclear receptor
    Gene Biotype PROTEIN_CODING"
    Interpro Acc IPR000536
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors
    GuideToPharmacology Gene Category ID 86
    GuideToPharmacology Gene Type nhr
    (11 More Sources)

    Publications:

    Inoue et al., 1998, Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells., Biochem. Biophys. Res. Commun.
    Kondo et al., Ligand-dependent transcriptional activities of four torafugu pufferfish Takifugu rubripes peroxisome proliferator-activated receptors., Gen. Comp. Endocrinol.
    Xu et al., 1999, Molecular recognition of fatty acids by peroxisome proliferator-activated receptors., Mol. Cell
    Caldari-Torres et al., 2006, Differential effects of n-3 and n-6 fatty acids on prostaglandin F2alpha production by bovine endometrial cells., J. Dairy Sci.
    Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.
    Ali et al., 2006, Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts., Am. J. Respir. Cell Mol. Biol.
    Liou et al., 2007, Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon., Cancer Res.
    He et al., 1999, PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs., Cell
    Babbar et al., 2003, Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer., J. Biol. Chem.
    Kim et al., 2006, Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)., Carcinogenesis
    Jarvis et al., 2005, Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line., Oncogene
    Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Planavila et al., 2005, Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells., Biochim. Biophys. Acta
    Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.
  • CHEMBL153057   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • DB959   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name DB-959
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

    Publications:

  • KD3010   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name KD3010
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

    Publications:

  • CHEMBL38508   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • CHEMBL435278   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • GW501516   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • GSK-9578   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • CHEMBL23296   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • L-796449   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • TRETINOIN   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True
    Direct Interaction? False

    Publications:

  • CHEMBL592652   PPARD

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • CER-002   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name CER-002
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

    Publications:

  • MBX-8025   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name MBX-8025
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist

    Publications:

  • SODELGLITAZAR   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist
    Direct Interaction yes

    Publications:

  • AVE0847   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor delta agonist
    Direct Interaction yes

    Publications:

  • ICOSAPENT   PPARD

    Interaction Types:
    agonist

    Interaction Info:

    Publications:
    Inoue et al., 1998, Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells., Biochem. Biophys. Res. Commun.
    Kondo et al., Ligand-dependent transcriptional activities of four torafugu pufferfish Takifugu rubripes peroxisome proliferator-activated receptors., Gen. Comp. Endocrinol.
    Xu et al., 1999, Molecular recognition of fatty acids by peroxisome proliferator-activated receptors., Mol. Cell

  • TREPROSTINIL   PPARD

    Interaction Types:
    agonist

    Interaction Info:

    Publications:
    Ali et al., 2006, Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts., Am. J. Respir. Cell Mol. Biol.

  • SULINDAC   PPARD

    Interaction Types:
    negative modulator

    Interaction Info:

    Publications:
    Liou et al., 2007, Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon., Cancer Res.
    He et al., 1999, PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs., Cell
    Babbar et al., 2003, Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer., J. Biol. Chem.

  • BEZAFIBRATE   PPARD

    Interaction Types:
    agonist

    Interaction Info:

    Publications:
    Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol

  • INDEGLITAZAR   PPARD

    Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist
    Direct Interaction yes

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • GLYCERIN   PPARD

    Interaction Types:
    agonist

    Interaction Info:

    Publications:

  • NETOGLITAZONE   PPARD

    Interaction Types:
    agonist

    Interaction Info:

    Publications:

  • ICOSAPENT ETHYL   PPARD

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name AMR102
    Novel drug target Established target

    Publications:

  • CHEMBL202609   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • CHEMBL523395   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • ATORVASTATIN   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Planavila et al., 2005, Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells., Biochim. Biophys. Acta

  • ALCOHOL   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.

  • VACCENIC ACID   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • ELAFIBRANOR   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • DOCETAXEL   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • THALIDOMIDE   PPARD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • Ensembl: ENSG00000112033

    • Version: 90_38

    Alternate Names:
    PPARD Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

  • RussLampel: ENSG00000112033

    • Version: 26-July-2011

    Alternate Names:
    PPARD Display Id
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA (PPAR-DELTA) (PPAR- BETA) (NUCLEAR HORMONE RECEPTOR 1) (NUC1) (NUCI). [SOURCE:UNIPROT/SWISSPROT;ACC:Q03181] Description
    ENSG00000112033 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

  • PharmGKB: PA33557

    • Version: 12-July-2012

    Alternate Names:
    peroxisome proliferator-activated receptor delta Gene Name
    ENSG00000112033 Ensembl Gene Id
    5467 Entrez Gene Id

    Gene Info:
    Is VIP false
    Has Variant Annotation true

    Publications:

  • dGene: 5467

    • Version: 27-June-2013

    Alternate Names:
    PPARD Gene Symbol
    5467 Entrez Gene Id

    Gene Info:
    Human Readable Name NUCLEAR HORMONE RECEPTOR

    Publications:

  • BaderLabGenes: PPARD

    • Version: February-2014

    Alternate Names:
    5467 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1C2
    Counted Citations from 1950-2000 900
    Gene Category Nuclear Hormone Receptors

    Publications:

  • HopkinsGroom: Q03181

    • Version: 11-September-2012

    Alternate Names:
    5467 Entrez Gene Id
    PPARD_HUMAN Uniprot Id
    ENSG00000112033 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR000536
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Name Nuclear hormone receptor, ligand-binding, core

    Publications:

  • GuideToPharmacologyGenes: 594

    • Version: 4-March-2015

    Alternate Names:
    peroxisome proliferator-activated receptor delta HUGO Gene Name
    9235 HUGO Gene ID
    PPARD Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors
    GuideToPharmacology Gene Category ID 86
    GuideToPharmacology Gene Type nhr

    Publications:

  • TdgClinicalTrial: Q03181

    • Version: January-2014

    Alternate Names:
    PPARD Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • DrugBank: BE0001007

    • Version: 5.0.8

    Alternate Names:
    PPARD DrugBank Gene Name
    Q03181 UniProt Accession
    5467 Entrez Gene Id

    Gene Info:

    Publications:
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • NCI: PPARD

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.
    Planavila et al., 2005, Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells., Biochim. Biophys. Acta

  • GuideToPharmacologyInteractions: 594

    • Version: 27-September-2017

    Alternate Names:
    Peroxisome proliferator-activated receptor-β/δ GuideToPharmacology Name
    Q03181 UniProtKB ID

    Gene Info:

    Publications:

  • TTD: TTDC00069

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    5467 Entrez Gene Id
    PPAR-BETA Gene Synonym
    NUCLEAR HORMONE RECEPTOR 1 Gene Synonym

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000112033

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000112033 Gene Symbol
    PPARD Ensembl Id

    Gene Info:

    Publications:

  • GO: PPARD

    • Version: 27-September-2017

    Alternate Names:
    Q03181 UniProtKB ID
    PPARD_HUMAN GO Gene Synonym
    NR1C2 GO Gene Synonym

    Gene Info:

    Publications:

  • ChemblInteractions: NR1C2

    • Version: chembl_23

    Alternate Names:
    PPARB GENE_SYMBOL
    PPARD GENE_SYMBOL
    Peroxisome proliferator-activated receptor delta UNIPROT

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25