• P2RX7 5027 Druggable GenomeDrug Resistance

    Alternate Names:

    5027
    PURINERGIC RECEPTOR P2X 7
    P2RX7
    P2X7
    602566
    8537
    ENSG00000089041
    OTTHUMG00000169153
    P2X purinoceptor 7
    Purinergic receptor
    P2Z receptor
    ATP receptor
    484
    NM_002562
    Q99572
    NP_002553
    purinergic receptor P2X, ligand-gated ion channel, 7
    P2RX7_HUMAN
    TTDC00218
    ADENOSINE P2X7 RECEPTOR
    P2X PURINOCEPTOR 7 (ATP RECEPTOR) (P2X7) (PURINERGIC RECEPTOR) (P2Z RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q99572]

    Gene Info:

    GuideToPharmacology Gene Category Name P2X receptors
    GuideToPharmacology Gene Category ID 77
    GuideToPharmacology Gene Type lgic
    Gene Biotype PROTEIN_CODING"
    Target Class Receptors
    Target Subclass TC:1.A.7.1.3
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Name P2X purinoreceptor
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name P2X_purnocptor
    Interpro Acc IPR001429
    (6 More Sources)

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction P2X purinoceptor 7 antagonist
    Direct Interaction yes
    Trial Name EVT-401

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? True
    Direct Interaction? False

    Publications:

  • Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    allosteric modulator

    Interaction Info:
    Details of the Assay for Interaction Inhibition of ATP-induced 86Rb+ (K<sup>+</sup>) efflux in human B-lymphocytes
    Specific Action of the Ligand Negative
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Details of Interaction pA<sub>2</sub> = 7.4
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction P2X purinoceptor 7 negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction P2X purinoceptor 7 antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction P2X purinoceptor 7 antagonist
    Direct Interaction yes

    Publications:

    • Version: 90_38

    Alternate Names:
    P2RX7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: January-2014

    Alternate Names:
    P2RX7 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.7.1.3

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    P2X PURINOCEPTOR 7 (ATP RECEPTOR) (P2X7) (PURINERGIC RECEPTOR) (P2Z RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q99572] Description
    ENSG00000089041 Ensembl Gene Id
    P2RX7 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000089041 Ensembl Gene Id
    Q99572 Uniprot Accession
    P2X PURINOCEPTOR 7 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Uniprot Status Swiss-Prot

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    purinergic receptor P2X, ligand-gated ion channel, 7 HUGO Gene Name
    8537 HUGO Gene ID
    P2RX7 Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name P2X receptors
    GuideToPharmacology Gene Category ID 77
    GuideToPharmacology Gene Type lgic

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    P2X7 GuideToPharmacology Name
    Q99572 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    P2X7 Gene Synonym
    ATP RECEPTOR Gene Synonym
    P2Z RECEPTOR Gene Synonym

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    P2RX7 GENE_SYMBOL
    P2X purinoceptor 7 UNIPROT
    ATP receptor UNIPROT

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    Q99572 UniProtKB ID
    P2RX7_HUMAN GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000089041 Gene Symbol
    P2RX7 Ensembl Id

    Gene Info:

    Publications: