DGIdb - NRG1 Gene Record

NRG1 3084 Druggable Genome

Alternate Names:

3084
NEUREGULIN 1
NRG1
ARIA
GGF
GGF2
HGL
HRG
HRG1
HRGA
MST131
MSTP131
NDF
NRG1-IT2
SMDF
142445
7997
ENSG00000157168
OTTHUMG00000163918
2593
NRG1_HUMAN
Q02297

Gene Info:

Gene Biotype	PROTEIN_CODING"

(2 More Sources)

Publications:

Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.
Vadlamudi et al., 1999, Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells., Cancer Res.
Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.
Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.
Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.
Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.
Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer
Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.
Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation
Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene
Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia
Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.
Kondapaka et al., 1997, Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells., Int. J. Cancer
Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.
Timmons et al., 2005, Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans., BMC Biol.
Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation
Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer
Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science
Ando et al., 2002, A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains., Cancer Res.
Wilson et al., 2011, Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers., Cancer Cell
Leung et al., 2015, Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer., Oncotarget
Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med
Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med
Mendell et al., 2015, Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer., EBioMedicine
Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.

AFATINIB NRG1

Interaction Types:

n/a

Interaction Info:

Drug family ERBB2&EGFR inhibitor 2nd gen

Alteration NRG1__.

Publications:
CHEMBL35482 NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.
DACTINOMYCIN NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Vadlamudi et al., 1999, Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells., Cancer Res.
ASPIRIN NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.
BUPIVACAINE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.
COLCHICINE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.
CYTARABINE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.
DEXAMETHASONE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer

GENISTEIN NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.

ISOPROTERENOL NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation

MYCOPHENOLIC ACID NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene

ETHYL NITROSOUREA NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia

NICOTINE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.

CHEMBL29197 NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Kondapaka et al., 1997, Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells., Int. J. Cancer

PROGESTERONE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.

BEVACIZUMAB NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Timmons et al., 2005, Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans., BMC Biol.
VINCRISTINE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation
WORTMANNIN NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
TAMOXIFEN NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer
PHORBOL MYRISTATE ACETATE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science
CHEMBL411250 NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Ando et al., 2002, A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains., Cancer Res.

LAPATINIB NRG1

Interaction Types:

n/a

Interaction Info:

Drug family ERBB2 inhibitor

Alteration NRG1__.

Publications:

Wilson et al., 2011, Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers., Cancer Cell

Leung et al., 2015, Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer., Oncotarget

CETUXIMAB NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med
CARBOPLATIN NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med
GEMCITABINE NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med
PACLITAXEL NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

Patritumab NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Mendell et al., 2015, Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer., EBioMedicine

AV-203 NRG1

Interaction Types:

n/a

Interaction Info:

Publications:

Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.

Ensembl: ENSG00000157168
- Version: 90_38
Alternate Names:

NRG1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING"

Publications:

CIViC: NRG1

Version: 27-September-2017

Alternate Names:

3084 Entrez Gene ID

2593 CIViC Gene ID

Gene Info:

Publications:

Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.

NCI: NRG1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.

Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.

Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia

HingoraniCasas: ENSG00000157168
- Version: 31-May-2017
Alternate Names:

ENSG00000157168 Gene Symbol

NRG1 Ensembl Id

Gene Info:

Publications:
GO: NRG1
- Version: 27-September-2017
Alternate Names:

Q02297 UniProtKB ID

NRG1_HUMAN GO Gene Synonym

GGF GO Gene Synonym

Gene Info:

Publications:
CGI: NRG1
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:

Q02297	UniProtKB ID
NRG1_HUMAN	GO Gene Synonym
GGF	GO Gene Synonym

NRG1 Gene Record

NRG1 3084 Druggable Genome

Alternate Names:

Gene Info:

Publications:

Interaction Types: n/a

Interaction Info: Drug family ERBB2&EGFR inhibitor 2nd gen Alteration NRG1__.

Publications:

Interaction Types: n/a

Interaction Info:

Publications: Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.

Interaction Types: n/a

Interaction Info:

Publications: Vadlamudi et al., 1999, Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells., Cancer Res.

Interaction Types: n/a

Interaction Info:

Publications: Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.

Interaction Types: n/a

Interaction Info:

Publications: Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.

Interaction Types: n/a

Interaction Info:

Publications: Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.

Interaction Types: n/a

Interaction Info:

Publications: Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.

Interaction Types: n/a

Interaction Info:

Publications: Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer

Interaction Types: n/a

Interaction Info:

Publications: Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.

Interaction Types: n/a

Interaction Info:

Publications: Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation

Interaction Types: n/a

Interaction Info:

Publications: Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene

Interaction Types: n/a

Interaction Info:

Publications: Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia

Interaction Types: n/a

Interaction Info:

Publications: Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.

Interaction Types: n/a

Interaction Info:

Publications: Kondapaka et al., 1997, Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells., Int. J. Cancer

Interaction Types: n/a

Interaction Info:

Publications: Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.

Interaction Types: n/a

Interaction Info:

Publications: Timmons et al., 2005, Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans., BMC Biol.

Interaction Types: n/a

Interaction Info:

Publications: Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation

Interaction Types: n/a

Interaction Info:

Publications: Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.

Interaction Types: n/a

Interaction Info:

Publications: Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer

Interaction Types: n/a

Interaction Info:

Publications: Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science

Interaction Types: n/a

Interaction Info:

Publications: Ando et al., 2002, A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains., Cancer Res.

Interaction Types: n/a

Interaction Info: Drug family ERBB2 inhibitor Alteration NRG1__.

Interaction Types: n/a

Interaction Info:

Publications: Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med

Interaction Types: n/a

Interaction Info:

Publications: Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

Interaction Types: n/a

Interaction Info:

Publications: Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

Interaction Types: n/a

Interaction Types:

n/a

Interaction Info:

Drug family ERBB2&EGFR inhibitor 2nd gen

Alteration NRG1__.

Interaction Types:

n/a

Publications:

Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.

Interaction Types:

n/a

Publications:

Vadlamudi et al., 1999, Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells., Cancer Res.

Interaction Types:

n/a

Publications:

Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.

Interaction Types:

n/a

Publications:

Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.

Interaction Types:

n/a

Publications:

Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.

Interaction Types:

n/a

Publications:

Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.

Interaction Types:

n/a

Publications:

Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer

Interaction Types:

n/a

Publications:

Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.

Interaction Types:

n/a

Publications:

Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation

Interaction Types:

n/a

Publications:

Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene

Interaction Types:

n/a

Publications:

Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia

Interaction Types:

n/a

Publications:

Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.

Interaction Types:

n/a

Publications:

Kondapaka et al., 1997, Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells., Int. J. Cancer

Interaction Types:

n/a

Publications:

Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.

Interaction Types:

n/a

Publications:

Timmons et al., 2005, Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans., BMC Biol.

Interaction Types:

n/a

Publications:

Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation

Interaction Types:

n/a

Publications:

Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.

Interaction Types:

n/a

Publications:

Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer

Interaction Types:

n/a

Publications:

Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science

Interaction Types:

n/a

Publications:

Ando et al., 2002, A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains., Cancer Res.

Interaction Types:

n/a

Interaction Info:

Drug family ERBB2 inhibitor

Alteration NRG1__.

Interaction Types:

n/a

Publications:

Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med

Interaction Types:

n/a

Publications:

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

Interaction Types:

n/a

Publications:

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

Interaction Types:

n/a

Publications:

Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

Interaction Types:

n/a

Publications:

Mendell et al., 2015, Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer., EBioMedicine

Interaction Types:

n/a

Publications:

Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.

Alternate Names:

NRG1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING"

Alternate Names:

3084 Entrez Gene ID

2593 CIViC Gene ID

Alternate Names:

ENSG00000157168 Gene Symbol

NRG1 Ensembl Id

Alternate Names:

Q02297 UniProtKB ID

NRG1_HUMAN GO Gene Synonym

GGF GO Gene Synonym