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NRG1 Gene Record

categories for NRG1
  • Summary
  • Interactions
  • Claims
  • NRG1 3084 Druggable Genome

    Alternate Names:

    3084
    NEUREGULIN 1
    NRG1
    ARIA
    GGF
    GGF2
    HGL
    HRG
    HRG1
    HRGA
    MST131
    MSTP131
    NDF
    NRG1-IT2
    SMDF
    142445
    7997
    ENSG00000157168
    OTTHUMG00000163918
    2593
    NRG1_HUMAN
    Q02297

    Gene Info:

    Gene Biotype PROTEIN_CODING"
    (2 More Sources)

    Publications:

    Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.
    Vadlamudi et al., 1999, Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells., Cancer Res.
    Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.
    Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.
    Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.
    Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.
    Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer
    Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.
    Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation
    Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene
    Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia
    Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.
    Kondapaka et al., 1997, Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells., Int. J. Cancer
    Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.
    Timmons et al., 2005, Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans., BMC Biol.
    Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation
    Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
    Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer
    Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science
    Ando et al., 2002, A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains., Cancer Res.
    Wilson et al., 2011, Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers., Cancer Cell
    Leung et al., 2015, Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer., Oncotarget
    Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med
    Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med
    Mendell et al., 2015, Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer., EBioMedicine
    Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.
  • AFATINIB   NRG1

    Interaction Types:
    n/a

    Interaction Info:
    Drug family ERBB2&EGFR inhibitor 2nd gen
    Alteration NRG1__.

    Publications:

  • CHEMBL35482   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.

  • DACTINOMYCIN   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Vadlamudi et al., 1999, Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells., Cancer Res.

  • ASPIRIN   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.

  • BUPIVACAINE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.

  • COLCHICINE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.

  • CYTARABINE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.

  • DEXAMETHASONE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer

  • GENISTEIN   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.

  • ISOPROTERENOL   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Lemmens et al., 2004, Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase., Circulation

  • MYCOPHENOLIC ACID   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Balañá et al., 1999, Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas., Oncogene

  • ETHYL NITROSOUREA   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia

  • NICOTINE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Zhong et al., 2008, Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors., J. Neurosci.

  • CHEMBL29197   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Kondapaka et al., 1997, Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells., Int. J. Cancer

  • PROGESTERONE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Labriola et al., 2003, Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells., Mol. Cell. Biol.

  • BEVACIZUMAB   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Timmons et al., 2005, Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans., BMC Biol.

  • VINCRISTINE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Vellon et al., 2007, Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner., Differentiation

  • WORTMANNIN   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.

  • TAMOXIFEN   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Akinmade et al., 2008, Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells., Br. J. Cancer

  • PHORBOL MYRISTATE ACETATE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science

  • CHEMBL411250   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Ando et al., 2002, A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains., Cancer Res.

  • LAPATINIB   NRG1

    Interaction Types:
    n/a

    Interaction Info:
    Drug family ERBB2 inhibitor
    Alteration NRG1__.

    Publications:
    Wilson et al., 2011, Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers., Cancer Cell
    Leung et al., 2015, Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer., Oncotarget

  • CETUXIMAB   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med

  • CARBOPLATIN   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

  • GEMCITABINE   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

  • PACLITAXEL   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med

  • Patritumab   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Mendell et al., 2015, Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer., EBioMedicine

  • AV-203   NRG1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.

  • Ensembl: ENSG00000157168

    • Version: 90_38

    Alternate Names:
    NRG1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

  • CIViC: NRG1

    • Version: 27-September-2017

    Alternate Names:
    3084 Entrez Gene ID
    2593 CIViC Gene ID

    Gene Info:

    Publications:
    Yonesaka et al., 2011, Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab., Sci Transl Med
    Hegde et al., 2013, Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer., Sci Transl Med
    Meetze et al., 2015, Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models., Clin. Cancer Res.

  • NCI: NRG1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kumar et al., 2008, Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells., Mol. Pharmacol.
    Petersen et al., 1989, High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma., Bone Marrow Transplant.
    Frohnert et al., 2003, Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line., Glia

  • HingoraniCasas: ENSG00000157168

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000157168 Gene Symbol
    NRG1 Ensembl Id

    Gene Info:

    Publications:

  • GO: NRG1

    • Version: 27-September-2017

    Alternate Names:
    Q02297 UniProtKB ID
    NRG1_HUMAN GO Gene Synonym
    GGF GO Gene Synonym

    Gene Info:

    Publications:

  • CGI: NRG1

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25