• NR1H2 7376 Druggable Genome

    Alternate Names:

    7376
    NUCLEAR RECEPTOR SUBFAMILY 1 GROUP H MEMBER 2
    NR1H2
    LXR-b
    LXRB
    NER
    NER-I
    RIP15
    UNR
    600380
    7965
    ENSG00000131408
    OTTHUMG00000183036
    NR1H2_HUMAN
    P55055
    BE0001598
    Ubiquitously-expressed nuclear receptor
    Nuclear receptor NER
    Liver X receptor beta
    Oxysterols receptor LXR-beta
    OXYSTEROLS RECEPTOR LXR-BETA (LIVER X RECEPTOR BETA) (NUCLEAR ORPHAN RECEPTOR LXR-BETA) (UBIQUITOUSLY-EXPRESSED NUCLEAR RECEPTOR) (NUCLEAR RECEPTOR NER). [SOURCE:UNIPROT/SWISSPROT;ACC:P55055]
    601
    Liver X receptor-β

    Gene Info:

    Initial Gene Query NR1H2
    Counted Citations from 1950-2000 958
    Gene Category Nuclear Hormone Receptors
    Gene Biotype PROTEIN_CODING"
    Interpro Acc IPR000536
    Interpro Type Domain
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    (6 More Sources)
  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? True

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? True
    Direct Interaction? False

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? True

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Details of the Assay for Interaction Binned data point measured in a luciferase transactivation assay in HEK293 cells expressing the hLXRβ ligand binding domain (aa 153-461)
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction LXR-beta agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    modulator

    Interaction Info:
    Mechanism of Interaction LXR-beta modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction LXR-beta agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction LXR-beta agonist

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction LXR-beta agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False