• MAP2K2 5605 Druggable GenomeClinically Actionable

    Alternate Names:

    5605
    MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
    MAP2K2
    CFC4
    MAPKK2
    MEK2
    MKK2
    PRKMK2
    601263
    6842
    ENSG00000126934
    OTTHUMG00000134286
    P36507
    DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
    MP2K2_HUMAN
    ERK activator kinase 2
    MAPK/ERK kinase 2
    MAP kinase kinase 2
    MAPKK 2
    MEK 2
    BE0004744
    MEK
    2063
    DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (EC 2.7.1.-) (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR KINASE 2) (MAPK/ERK KINASE 2) (MEK2). [SOURCE:UNIPROT/SWISSPROT;ACC:P36507]
    NP_109587
    NM_030662

    Gene Info:

    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name KINASE
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Source Reported Gene Name MAP2K2
    Gene Category CLINICALLY ACTIONABLE
    Gene Biotype PROTEIN_CODING"
    Target Class Enzymes
    Target Subclass EC:2.7.12.2
    GuideToPharmacology Gene Category Name STE7 family
    GuideToPharmacology Gene Category ID 623
    GuideToPharmacology Gene Type enzyme
    Human Readable Name SERINE THREONINE KINASE
    (13 More Sources)
  • Interaction Types:
    inhibitor
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Negative

    Publications:

  • Interaction Types:
    inhibitor
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name WX-554
    Novel drug target Novel Target
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name ARRY-300
    Novel drug target Novel Target

    Publications:

    • Version: 90_38

    Alternate Names:
    MAP2K2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    P36507 Uniprot Accession
    5605 Entrez Gene Id
    ENSG00000126934 Ensembl Gene Id

    Gene Info:
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002290

    Publications:

    • Version: 27-June-2013

    Alternate Names:
    5605 Entrez Gene Id
    MAP2K2 Gene Symbol

    Gene Info:
    Human Readable Name SERINE THREONINE KINASE

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    mitogen-activated protein kinase kinase 2 HUGO Gene Name
    6842 HUGO Gene ID
    MAP2K2 Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name STE7 family
    GuideToPharmacology Gene Category ID 623
    GuideToPharmacology Gene Type enzyme

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (EC 2.7.1.-) (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR KINASE 2) (MAPK/ERK KINASE 2) (MEK2). [SOURCE:UNIPROT/SWISSPROT;ACC:P36507] Description
    MAP2K2 Display Id
    ENSG00000126934 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    MAP2K2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.12.2

    Publications:

    • Version: 20-September-2013

    Alternate Names:
    5605 Entrez Gene ID

    Gene Info:
    Source Reported Gene Name MAP2K2
    Gene Category CLINICALLY ACTIONABLE

    Publications:

    • Version: 5.0.8
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000126934 Gene Symbol
    MAP2K2 Ensembl Id

    Gene Info:

    Publications:

    • Version: 12-May-2016

    Alternate Names:
    MEK2 Gene Symbol

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    mitogen-activated protein kinase kinase 2 GuideToPharmacology Name
    P36507 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    P36507 UniProtKB ID
    MP2K2_HUMAN GO Gene Synonym
    MEK2 GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 20-Jun-2017

    Alternate Names:
    5605 Entrez Gene Id
    MAP2K2 MyCancerGenome Gene Symbol
    MEK MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    MKK2 GENE_SYMBOL
    PRKMK2 GENE_SYMBOL
    MAP2K2 GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Publications: