• ITGA2 3673 Druggable GenomeDrug Resistance

    Alternate Names:

    3673
    INTEGRIN SUBUNIT ALPHA 2
    ITGA2
    BR
    CD49B
    GPIa
    HPA-5
    VLA-2
    VLAA2
    192974
    6137
    ENSG00000164171
    OTTHUMG00000131165
    CD49 antigen-like family member B
    Collagen receptor
    VLA-2 subunit alpha
    Platelet membrane glycoprotein Ia
    Integrin alpha-2
    CD_antigen=CD49b
    INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301]
    ITA2_HUMAN
    P17301
    2579
    P05106
    integrin αIIbβ3

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING"
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000413
    Uniprot Status Swiss-Prot
    Interpro Short Name Integrin_alpha
    Interpro Name Integrin alpha chain
    (3 More Sources)

    Publications:

  • Interaction Types:
    antibody

    Interaction Info:
    Specific Action of the Ligand Binding
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction inhibition of human platelet aggregation. The IC50 varies according to the anti-coagulant used during blood collection.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction Inhibition of ADP (10 µM)-induced aggregation in human gel-filtered platelets.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction Displacement of biotinylated fibrinogen from human integrin αIIbβ3.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Integrin alpha-2 antagonist
    Direct Interaction yes

    Publications:

    • Version: 90_38

    Alternate Names:
    ITGA2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ITGA2 Uniprot Gene Name
    P17301 Uniprot Accession
    ITA2_HUMAN Uniprot Id

    Gene Info:
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000413

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ITGA2 Display Id
    ENSG00000164171 Ensembl Gene Id
    INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    integrin αIIbβ3 GuideToPharmacology Name
    P05106 UniProtKB ID
    P17301 UniProtKB ID

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    CD49B GENE_SYMBOL
    ITGA2 GENE_SYMBOL
    Integrin alpha-2 UNIPROT

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    P17301 UniProtKB ID
    ITA2_HUMAN GO Gene Synonym
    CD49B GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164171 Gene Symbol
    ITGA2 Ensembl Id

    Gene Info:

    Publications: