• Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C = GluN2B > GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D = GluN2B > GluN2C = GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2B ≥ GluN2A ≥ GluN2D > GluN2C; partial agonist at GluN2A and GluN2C

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2D > GluN2C = GluN2B > GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Details of Interaction GluN2B > GluN2D = GluN2C = GluN2A

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Details of Interaction GluN2D ≥ GluN2C > GluN2A ≥ GluN2B

    Publications:

  • Interaction Types:
    antagonist
    channel blocker

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Details of Interaction GluN2C = GluN2D &ge; GluN2B &ge; GluN2A

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction GluN2A = GluN2B > GluN2C = GluN2D
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction GluN2A = GluN2B >> GluN2C = GluN2D
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    partial agonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    partial agonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor blocker
    Direct Interaction yes
    Trial Name CNS-5161

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes
    Trial Name V3381

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Trial Name AZD-6765
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name dimiracetam, NT-11624
    Novel drug target Novel Target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name Dimebon
    Novel drug target Novel Target

    Publications: