• Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Trial Name EVT-101
    Novel drug target Established target
    Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Trial Name CNS-5161
    Novel drug target Established target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C = GluN2B > GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D = GluN2B > GluN2C = GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2B ≥ GluN2A ≥ GluN2D > GluN2C; partial agonist at GluN2A and GluN2C

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2D > GluN2C = GluN2B > GluN2A

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Details of Interaction GluN2B > GluN2D = GluN2C = GluN2A

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Details of Interaction GluN2A > GluN2B (human), but weakly selective for rat GluN2A versus GluN2B

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Details of Interaction GluN2D ≥ GluN2C > GluN2A ≥ GluN2B

    Publications:

  • Interaction Types:
    antagonist
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction GluN2C = GluN2D ≥ GluN2B ≥ GluN2A
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction GluN2A = GluN2B > GluN2C = GluN2D
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction GluN2A = GluN2B >> GluN2C = GluN2D
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    partial agonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    partial agonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Trial Name V3381
    Novel drug target Established target
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    blocker

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor blocker
    Direct Interaction yes
    Trial Name AZD-6765

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    antagonist

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name memantine
    Novel drug target Established target
    Trial Name Namenda

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name dexanabinol, HU-211
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name dimiracetam, NT-11624
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name Dimebon
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name neramexane mesylate
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications:

    • Version: 90_38

    Alternate Names:
    GRIN2B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    2904 Entrez Gene Id
    Q13224 Uniprot Accession
    GRIN2B Gene Symbol

    Gene Info:
    Target Main Class Receptors
    Target Subclass Ligand_gated_ion_channels
    Transmembrane Helix Count 4

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    glutamate receptor, ionotropic, N-methyl D-aspartate 2B HUGO Gene Name
    4586 HUGO Gene ID
    GRIN2B Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75
    GuideToPharmacology Gene Type lgic

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    GRIN2B Uniprot Gene Name
    NMDE2_HUMAN Uniprot Id
    2904 Entrez Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001320

    Publications:

    • Version: January-2014

    Alternate Names:
    GRIN2B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GRIN2B Display Id
    ENSG00000150086 Ensembl Gene Id
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 2 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2B) (NR2B) (NMDAR2B) (N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 3) (NR3) (HNR3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13224] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 12-July-2012

    Alternate Names:
    GRIN2B Gene Symbol
    ENSG00000150086 Ensembl Gene Id
    glutamate receptor, ionotropic, N-methyl D-aspartate 2B Gene Name

    Gene Info:
    Has Variant Annotation true
    Is VIP false

    Publications:

    • Version: 5.0.8
    • Version: 27-September-2017

    Alternate Names:
    GluN2B GuideToPharmacology Name
    Q13224 UniProtKB ID

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    NMDAR2B GENE_SYMBOL
    GRIN2B GENE_SYMBOL
    Glutamate receptor ionotropic, NMDA 2B UNIPROT

    Gene Info:

    Publications:

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    NR3 Gene Synonym
    Q13224 Uniprot Accession
    NMDA RECEPTOR SUBUNIT 2B Gene Synonym

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    Q13224 UniProtKB ID
    NMDE2_HUMAN GO Gene Synonym
    NMDAR2B GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000150086 Gene Symbol
    GRIN2B Ensembl Id

    Gene Info:

    Publications: