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GHR Gene Record

categories for GHR
  • Summary
  • Interactions
  • Claims
  • GHR 2690 Druggable Genome

    Alternate Names:

    2690
    GROWTH HORMONE RECEPTOR
    GHR
    GHBP
    GHIP
    600946
    4263
    ENSG00000112964
    OTTHUMG00000094791
    BE0000075
    P10912
    GHR_HUMAN
    Somatotropin receptor
    Serum-binding protein
    Growth hormone-binding protein
    GH receptor
    GH-binding protein
    TTDC00345
    MRNA OF GROWTH HORMONE RECEPTOR
    MRNA OF GHR
    MRNA OF GH RECEPTOR
    MRNA OF SOMATOTROPIN RECEPTOR
    TTDS00076
    SERUM BINDING PROTEIN
    1720

    Gene Info:

    Target Main Class Receptors
    Transmembrane Helix Count 1
    Target Subclass IG
    Target Subclass Type1
    Target Subclass CytokineR
    Gene Biotype PROTEIN_CODING"
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor
    (6 More Sources)

    Publications:

    Adriani et al., 2006, Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus., J. Immunol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Choi et al., 2006, Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B., Nat. Cell Biol.
    Bernstein et al., 2007, Hormones and body size evolution in papionin primates., Am. J. Phys. Anthropol.
    Wu et al., 2006, [Correlation of growth hormone receptor expression to preoperative radiosensitivity of rectal cancer patients]., Ai Zheng
    Walenkamp et al., 2006, Genetic disorders in the growth hormone - insulin-like growth factor-I axis., Horm. Res.
    De Martino et al., 2010, The treatment with growth hormone receptor antagonist in acromegaly: effect on vascular structure and function in patients resistant to somatostatin analogues., J. Endocrinol. Invest.
    Moller et al., 2009, Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects., J. Clin. Endocrinol. Metab.
    Paisley et al., 2007, Pegvisomant interference in GH assays results in underestimation of GH levels., Eur. J. Endocrinol.
  • PEGVISOMANT   GHR

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:
    De Martino et al., 2010, The treatment with growth hormone receptor antagonist in acromegaly: effect on vascular structure and function in patients resistant to somatostatin analogues., J. Endocrinol. Invest.
    Moller et al., 2009, Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects., J. Clin. Endocrinol. Metab.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • SOMATREM   GHR

    Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction Growth hormone receptor agonist
    Direct Interaction yes

    Publications:

  • SOMATROPIN   GHR

    Interaction Types:
    agonist
    binder

    Interaction Info:
    Trial Name Norditropin
    Novel drug target Established target
    Mechanism of Interaction Growth hormone receptor agonist

    Publications:
    Adriani et al., 2006, Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus., J. Immunol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Choi et al., 2006, Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B., Nat. Cell Biol.

  • CHEMBL18872   GHR

    Interaction Types:
    agonist

    Interaction Info:

    Publications:

  • IBUTAMOREN   GHR

    Interaction Types:
    binder

    Interaction Info:

    Publications:

  • CHEMBL324218   GHR

    Interaction Types:
    agonist

    Interaction Info:

    Publications:

  • Ensembl: ENSG00000112964

    • Version: 90_38

    Alternate Names:
    GHR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

  • TEND: P10912

    • Version: 01-August-2011

    Alternate Names:
    2690 Entrez Gene Id
    GHR Gene Symbol
    GHR_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Transmembrane Helix Count 1
    Target Subclass IG

    Publications:

  • TdgClinicalTrial: P10912

    • Version: January-2014

    Alternate Names:
    GHR Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor

    Publications:

  • DrugBank: BE0000075

    • Version: 5.0.8

    Alternate Names:
    GHR DrugBank Gene Name
    P10912 UniProt Accession
    2690 Entrez Gene Id

    Gene Info:

    Publications:
    De Martino et al., 2010, The treatment with growth hormone receptor antagonist in acromegaly: effect on vascular structure and function in patients resistant to somatostatin analogues., J. Endocrinol. Invest.
    Moller et al., 2009, Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects., J. Clin. Endocrinol. Metab.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • GuideToPharmacologyInteractions: 1720

    • Version: 27-September-2017

    Alternate Names:
    Growth hormone receptor GuideToPharmacology Name
    P10912 UniProtKB ID

    Gene Info:

    Publications:

  • ChemblInteractions: GHR

    • Version: chembl_23

    Alternate Names:
    GHR GENE_SYMBOL
    Growth hormone receptor UNIPROT
    Growth hormone-binding protein UNIPROT

    Gene Info:

    Publications:

  • TTD: TTDS00076

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    SERUM BINDING PROTEIN Gene Synonym
    SOMATOTROPIN RECEPTOR Gene Synonym
    GH RECEPTOR Gene Synonym

    Gene Info:

    Publications:

  • GO: GHR

    • Version: 27-September-2017

    Alternate Names:
    P10912 UniProtKB ID
    GHR_HUMAN GO Gene Synonym

    Gene Info:

    Publications:

  • TTD: TTDC00345

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    MRNA OF SOMATOTROPIN RECEPTOR Gene Synonym
    2690 Entrez Gene Id
    P10912 Uniprot Accession

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000112964

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000112964 Gene Symbol
    GHR Ensembl Id

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25