• GABRQ 55879 Druggable Genome

    Alternate Names:

    55879
    GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR THETA SUBUNIT
    GABRQ
    THETA
    300349
    14454
    ENSG00000268089
    OTTHUMG00000022649
    418
    Q9UN88
    gamma-aminobutyric acid (GABA) A receptor, theta
    θ
    NM_018558
    NP_061028
    GBRT_HUMAN
    GABRG3
    ENSG00000147402
    GABA(A) receptor subunit theta
    Gamma-aminobutyric acid receptor subunit theta
    GABA<sub>A</sub> receptor &theta; subunit
    GAMMA-AMINOBUTYRIC-ACID RECEPTOR THETA SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UN88]
    BE0003597

    Gene Info:

    GuideToPharmacology Gene Category Name GABA<sub>A</sub> receptors
    GuideToPharmacology Gene Category ID 72
    GuideToPharmacology Gene Type lgic
    Gene Biotype PROTEIN_CODING"
    Target Class Receptors
    Target Subclass TC:1.A.9
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Neur_channel
    Interpro Type Domain
    Interpro Name Neurotransmitter-gated ion-channel
    Uniprot Status Swiss-Prot
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Short Name Neur_chan_lig-bd
    Human Readable Name ION CHANNEL
    Interpro Type Family
    Interpro Acc IPR006201
    Interpro Acc IPR006202
    Uniprot Evidence 2: Evidence at transcript level
    Target Subclass Ligand_gated_ion_channels
    Target Subclass Channels
    Target Main Class Receptors
    Target Subclass cys-loop
    Transmembrane Helix Count 4
    (7 More Sources)
  • Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name Clobazam
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name JZP-8

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel agonist
    Direct Interaction yes

    Publications:

  • Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Trial Name ARX-03, sufentanil + triazolam NanoTab
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name ocinaplon
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name NG2-73
    Novel drug target Established target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    Publications: