2559 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR ALPHA6 SUBUNIT |
GABRA6 |
137143 |
4080 |
ENSG00000145863 |
OTTHUMG00000130351 |
BE0000764 |
Q16445 |
GBRA6_HUMAN |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-6 |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-6 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16445] |
GABA(A) receptor subunit alpha-6 |
409 |
NP_000802 |
NM_000811 |
α6 |
gamma-aminobutyric acid (GABA) A receptor, alpha 6 |
GABA<sub>A</sub> receptor α6 subunit |
Human Readable Name | ION CHANNEL |
Interpro Short Name | Neur_channel |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Interpro Short Name | Neur_chan_lig-bd |
Interpro Acc | IPR006202 |
Uniprot Status | Swiss-Prot |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 2: Evidence at transcript level |
Interpro Acc | IPR006201 |
Interpro Name | Neurotransmitter-gated ion-channel |
Interpro Type | Domain |
Interpro Type | Family |
Target Main Class | Receptors |
Target Subclass | cys-loop |
Target Subclass | Channels |
Transmembrane Helix Count | 4 |
Target Subclass | Ligand_gated_ion_channels |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
GuideToPharmacology Gene Category Name | GABA<sub>A</sub> receptors |
GuideToPharmacology Gene Category ID | 72 |
GuideToPharmacology Gene Type | lgic |
Gene Biotype | PROTEIN_CODING" |
agonist |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
agonist |
Mechanism of Interaction | GABA-A receptor; agonist GABA site agonist |
Direct Interaction | yes |
Specific Binding Site for Interaction | GABA site |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | Clobazam |
agonist |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Full agonist |
Details of Interaction | relatively high efficacy |
agonist |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Full agonist |
Details of Interaction | low efficacy |
agonist |
Specific Action of the Ligand | Inverse agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
allosteric modulator |
Specific Binding Site for Interaction | benzodiazepine site |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
allosteric modulator |
Specific Binding Site for Interaction | benzodiazepine site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
allosteric modulator |
Specific Binding Site for Interaction | benzodiazepine site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
allosteric modulator |
Specific Binding Site for Interaction | benzodiazepine site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
allosteric modulator |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | True |
Direct Interaction? | False |
allosteric modulator |
Specific Binding Site for Interaction | benzodiazepine site |
Specific Action of the Ligand | Partial agonist |
Details of Interaction | low affinity |
allosteric modulator |
Specific Action of the Ligand | Potentiation |
Endogenous Drug? | True |
Direct Interaction? | False |
antagonist |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
channel blocker |
Specific Action of the Ligand | None |
Endogenous Drug? | False |
Direct Interaction? | False |
channel blocker |
Specific Action of the Ligand | None |
Endogenous Drug? | False |
Direct Interaction? | False |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Trial Name | alprazolam,Xanax, Xanax XR |
Novel drug target | Established target |
Trial Name | AZ-002, Staccato alprazolam |
positive allosteric modulator |
Trial Name | JZP-8 |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
partial agonist |
Trial Name | NG2-73 |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site partial agonist |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
inverse agonist |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site inverse agonist |
Direct Interaction | yes |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
potentiator |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
positive allosteric modulator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
positive allosteric modulator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
positive allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
potentiator |
positive allosteric modulator |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
potentiator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | Ganaxolone |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
GABRA6 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING" |
4080 | HUGO Gene ID |
gamma-aminobutyric acid (GABA) A receptor, alpha 6 | HUGO Gene Name |
GABRA6 | Gene Symbol |
GuideToPharmacology Gene Category Name | GABA<sub>A</sub> receptors |
GuideToPharmacology Gene Category ID | 72 |
GuideToPharmacology Gene Type | lgic |
GBRA6_HUMAN | Uniprot Id |
Q16445 | Uniprot Accession |
2559 | Entrez Gene Id |
Target Main Class | Receptors |
Target Subclass | cys-loop |
Target Subclass | Channels |
ENSG00000145863 | Ensembl Gene Id |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-6 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16445] | Description |
GABRA6 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
GABRA6 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Q16445 | Uniprot Accession |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-6 | Uniprot Protein Name |
GBRA6_HUMAN | Uniprot Id |
Human Readable Name | ION CHANNEL |
Interpro Short Name | Neur_channel |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
GABRA6 | DrugBank Gene Name |
Q16445 | UniProt Accession |
2559 | Entrez Gene Id |
GABA<sub>A</sub> receptor α6 subunit | GuideToPharmacology Name |
Q16445 | UniProtKB ID |
GABRA6 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit alpha-6 | UNIPROT |
GABA(A) receptor subunit alpha-6 | UNIPROT |
Q16445 | UniProtKB ID |
GBRA6_HUMAN | GO Gene Synonym |
ENSG00000145863 | Gene Symbol |
GABRA6 | Ensembl Id |