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GABRA6 Gene Record

categories for GABRA6
  • Summary
  • Interactions
  • Claims
  • GABRA6 2559 Druggable Genome

    Alternate Names:

    2559
    GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR ALPHA6 SUBUNIT
    GABRA6
    137143
    4080
    ENSG00000145863
    OTTHUMG00000130351
    BE0000764
    Q16445
    GBRA6_HUMAN
    GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-6
    GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-6 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16445]
    GABA(A) receptor subunit alpha-6
    409
    NP_000802
    NM_000811
    α6
    gamma-aminobutyric acid (GABA) A receptor, alpha 6
    GABA<sub>A</sub> receptor &alpha;6 subunit

    Gene Info:

    Human Readable Name ION CHANNEL
    Interpro Short Name Neur_channel
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Short Name Neur_chan_lig-bd
    Interpro Acc IPR006202
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Acc IPR006201
    Interpro Name Neurotransmitter-gated ion-channel
    Interpro Type Domain
    Interpro Type Family
    Target Main Class Receptors
    Target Subclass cys-loop
    Target Subclass Channels
    Transmembrane Helix Count 4
    Target Subclass Ligand_gated_ion_channels
    Target Class Receptors
    Target Subclass TC:1.A.9
    GuideToPharmacology Gene Category Name GABA<sub>A</sub> receptors
    GuideToPharmacology Gene Category ID 72
    GuideToPharmacology Gene Type lgic
    Gene Biotype PROTEIN_CODING"
    (7 More Sources)

    Publications:

    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Giersch et al., 2010, Atypical behavioural effects of lorazepam: clues to the design of novel therapies?, Pharmacol. Ther.
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Gonzalez et al., 2009, Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies., J. Pharmacol. Exp. Ther.
    Rho et al., 1997, Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate., J. Pharmacol. Exp. Ther.
    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
    Olsen et al., 2011, GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation., Can J Anaesth
    You et al., 2010, Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes., Neuropharmacology
    Skilbeck et al., 2008, Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Santhakumar et al., 2006, Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene., J. Neurosci.
  • MEPROBAMATE   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel agonist

    Publications:
    Gonzalez et al., 2009, Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies., J. Pharmacol. Exp. Ther.
    Rho et al., 1997, Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate., J. Pharmacol. Exp. Ther.

  • GABOXADOL   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; agonist GABA site agonist
    Direct Interaction yes
    Specific Binding Site for Interaction GABA site

    Publications:

  • CLOBAZAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name Clobazam

    Publications:

  • ISOGUVACINE   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • ISONIPECOTIC ACID   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Full agonist
    Details of Interaction relatively high efficacy

    Publications:

  • MUSCIMOL   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • CHEMBL34155   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Full agonist
    Details of Interaction low efficacy

    Publications:

  • CGS-8216   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • CHEMBL70176   GABRA6

    Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • BRETAZENIL   GABRA6

    Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • CHEMBL274866   GABRA6

    Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • Ro-154513   GABRA6

    Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • ZINC ION   GABRA6

    Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? True
    Direct Interaction? False

    Publications:

  • FLUMAZENIL   GABRA6

    Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Partial agonist
    Details of Interaction low affinity

    Publications:

  • METHOCTRAMINE   GABRA6

    Interaction Types:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Potentiation
    Endogenous Drug? True
    Direct Interaction? False

    Publications:

  • BICUCULLINE   GABRA6

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • GABAZINE   GABRA6

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • PICROTOXIN   GABRA6

    Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • T-BUTYLBICYCLOPHOSPHOROTHIONATE   GABRA6

    Interaction Types:
    channel blocker

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • CLORAZEPATE DIPOTASSIUM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • CHLORDIAZEPOXIDE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:

  • DIAZEPAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • ALPRAZOLAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    Publications:

  • CLONAZEPAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name JZP-8
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:

  • ESTAZOLAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • BUTABARBITAL SODIUM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • LORAZEPAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:

  • METHOHEXITAL SODIUM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • METHYPRYLON   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • MIDAZOLAM HYDROCHLORIDE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • PENTOBARBITAL SODIUM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • SEVOFLURANE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • THIAMYLAL SODIUM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • FLURAZEPAM HYDROCHLORIDE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • HALAZEPAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • HALOTHANE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • ISOFLURANE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • PF-06372865   GABRA6

    Interaction Types:
    agonist

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel agonist
    Direct Interaction yes

    Publications:

  • PROPOFOL   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • Lorediplon   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site positive allosteric modulator
    Direct Interaction yes

    Publications:

  • PENTOBARBITAL   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:

  • ADIPIPLON   GABRA6

    Interaction Types:
    partial agonist

    Interaction Info:
    Trial Name NG2-73
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; benzodiazepine site partial agonist

    Publications:

  • CHLORDIAZEPOXIDE HYDROCHLORIDE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • ESZOPICLONE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • DESFLURANE   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • QUAZEPAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • SECOBARBITAL SODIUM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • THIOPENTAL SODIUM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • RESEQUINIL   GABRA6

    Interaction Types:
    inverse agonist

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site inverse agonist
    Direct Interaction yes

    Publications:

  • PRAZEPAM   GABRA6

    Interaction Types:
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    Publications:

  • TEMAZEPAM   GABRA6

    Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    Publications:
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Giersch et al., 2010, Atypical behavioural effects of lorazepam: clues to the design of novel therapies?, Pharmacol. Ther.

  • BUTALBITAL   GABRA6

    Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • TALBUTAL   GABRA6

    Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • SECOBARBITAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • METHARBITAL   GABRA6

    Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • THIOPENTAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • PRIMIDONE   GABRA6

    Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • OXAZEPAM   GABRA6

    Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    Publications:
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.

  • MEPHOBARBITAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Olsen et al., 2011, GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation., Can J Anaesth

  • TRIAZOLAM   GABRA6

    Interaction Types:
    potentiator
    positive allosteric modulator

    Interaction Info:
    Trial Name ARX-03, sufentanil + triazolam NanoTab
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    Publications:
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.

  • AMOBARBITAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • APROBARBITAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • BUTETHAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • HEPTABARBITAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • HEXOBARBITAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • BARBITAL   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

  • FLUNITRAZEPAM   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:
    You et al., 2010, Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes., Neuropharmacology
    Skilbeck et al., 2008, Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Santhakumar et al., 2006, Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene., J. Neurosci.

  • BROMAZEPAM   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.

  • NITRAZEPAM   GABRA6

    Interaction Types:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.

  • PHENOBARBITAL   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • GANAXOLONE   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name Ganaxolone
    Novel drug target Established target

    Publications:

  • METHOXYFLURANE   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • GLUTETHIMIDE   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • ENFLURANE   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • ETHCHLORVYNOL   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • ETOMIDATE   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • TOPIRAMATE   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • FLURAZEPAM   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • BUTABARBITAL   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • MIDAZOLAM   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • CLORAZEPIC ACID   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    Publications:

  • TRICLOFOS SODIUM   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • ACAMPROSATE CALCIUM   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    Publications:

  • OCINAPLON   GABRA6

    Interaction Types:
    n/a

    Interaction Info:
    Trial Name ocinaplon
    Novel drug target Established target

    Publications:

  • Ensembl: ENSG00000145863

    • Version: 90_38

    Alternate Names:
    GABRA6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

  • GuideToPharmacologyGenes: 409

    • Version: 4-March-2015

    Alternate Names:
    4080 HUGO Gene ID
    gamma-aminobutyric acid (GABA) A receptor, alpha 6 HUGO Gene Name
    GABRA6 Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name GABA<sub>A</sub> receptors
    GuideToPharmacology Gene Category ID 72
    GuideToPharmacology Gene Type lgic

    Publications:

  • TEND: Q16445

    • Version: 01-August-2011

    Alternate Names:
    GBRA6_HUMAN Uniprot Id
    Q16445 Uniprot Accession
    2559 Entrez Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass cys-loop
    Target Subclass Channels

    Publications:

  • RussLampel: ENSG00000145863

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000145863 Ensembl Gene Id
    GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-6 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16445] Description
    GABRA6 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q16445

    • Version: January-2014

    Alternate Names:
    GABRA6 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.9

    Publications:

  • HopkinsGroom: Q16445

    • Version: 11-September-2012

    Alternate Names:
    Q16445 Uniprot Accession
    GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-6 Uniprot Protein Name
    GBRA6_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name ION CHANNEL
    Interpro Short Name Neur_channel
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding

    Publications:

  • DrugBank: BE0000764

    • Version: 5.0.8

    Alternate Names:
    GABRA6 DrugBank Gene Name
    Q16445 UniProt Accession
    2559 Entrez Gene Id

    Gene Info:

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Olsen et al., 2011, GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation., Can J Anaesth

  • GuideToPharmacologyInteractions: 409

    • Version: 27-September-2017

    Alternate Names:
    GABA<sub>A</sub> receptor &alpha;6 subunit GuideToPharmacology Name
    Q16445 UniProtKB ID

    Gene Info:

    Publications:

  • ChemblInteractions: GABRA6

    • Version: chembl_23

    Alternate Names:
    GABRA6 GENE_SYMBOL
    Gamma-aminobutyric acid receptor subunit alpha-6 UNIPROT
    GABA(A) receptor subunit alpha-6 UNIPROT

    Gene Info:

    Publications:

  • GO: GABRA6

    • Version: 27-September-2017

    Alternate Names:
    Q16445 UniProtKB ID
    GBRA6_HUMAN GO Gene Synonym

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000145863

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000145863 Gene Symbol
    GABRA6 Ensembl Id

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25