DGIdb - FKBP1A Gene Record

FKBP1A 2280 Druggable Genome

Alternate Names:

2280
FK506 BINDING PROTEIN 1A
FKBP1A
FKBP-12
FKBP-1A
FKBP1
FKBP12
PKC12
PKCI2
PPIASE
186945
3711
ENSG00000088832
OTTHUMG00000031666
BE0000695
P62942
Peptidyl-prolyl cis-trans isomerase FKBP1A
12 kDa FK506-binding protein
Calstabin-1
FK506-binding protein 1A
Immunophilin FKBP12
Rotamase
PPIase FKBP1A
12 kDa FKBP
FKB1A_HUMAN
FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942]
TTDR00122
CYCLOPHILIN
PEPTIDYLPROLYL ISOMERASE
CYCLOSPORIN A-BINDING PROTEIN
PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
2609

Gene Info:

Target Class	Enzymes
Target Subclass	EC:5.2.1.8
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	PPIase_FKBP_dom
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001179
Interpro Type	Domain
Interpro Name	Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
Uniprot Evidence	1: Evidence at protein level
Target Main Class	Enzymes
Target Subclass	5.2.1.8
Gene Biotype	PROTEIN_CODING"

(8 More Sources)

Publications:

Reitamo et al., 2002, Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis., Am J Clin Dermatol
Labrande et al., 2006, Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa., Neuroscience
Masri et al., 2007, An assay for the determination of sirolimus levels in the lymphocyte of transplant patients., Transplant. Proc.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

TACROLIMUS FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Labrande et al., 2006, Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa., Neuroscience

Masri et al., 2007, An assay for the determination of sirolimus levels in the lymphocyte of transplant patients., Transplant. Proc.

SIROLIMUS FKBP1A

Interaction Types:

inhibitor

other

Interaction Info:

Trial Name LCP-Siro, sirolimus

Novel drug target Established target

Trial Name sirolimus, rapamycin,Perceiva

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.
ZOTAROLIMUS FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Specific Action of the Ligand Binding

Endogenous Drug? False

Direct Interaction? True

Publications:
EVEROLIMUS FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Mechanism of Interaction FK506-binding protein 1A inhibitor

Direct Interaction yes

Publications:
Olocrolimus FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Mechanism of Interaction FK506-binding protein 1A inhibitor

Direct Interaction yes

Publications:
TEMSIROLIMUS FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Mechanism of Interaction FK506-binding protein 1A inhibitor

Direct Interaction yes

Publications:
PIMECROLIMUS FKBP1A

Interaction Types:

inhibitor

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction FK506-binding protein 1A inhibitor

Publications:

Reitamo et al., 2002, Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis., Am J Clin Dermatol
RUCLOSPORIN FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Publications:
ALISPORIVIR FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Publications:
CHEMBL1269597 FKBP1A

Interaction Types:

inhibitor

Interaction Info:

Publications:

CHEMBL110674 FKBP1A

Interaction Types:

n/a

Interaction Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

GPI-1046 FKBP1A

Interaction Types:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
MYRISTIC ACID FKBP1A

Interaction Types:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
CHEMBL1235837 FKBP1A

Interaction Types:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
DORSOMORPHIN FKBP1A

Interaction Types:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Ensembl: ENSG00000088832
- Version: 90_38
Alternate Names:

FKBP1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING"

Publications:
TdgClinicalTrial: P62942
- Version: January-2014
Alternate Names:

FKBP1A Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:5.2.1.8

Publications:

RussLampel: ENSG00000088832

Version: 26-July-2011

Alternate Names:

FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942] Description

ENSG00000088832 Ensembl Gene Id

FKBP1A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Publications:

HopkinsGroom: P62942
- Version: 11-September-2012
Alternate Names:

ENSG00000088832 Ensembl Gene Id

P62942 Uniprot Accession

FKB1A_HUMAN Uniprot Id

Gene Info:

Interpro Short Name PPIase_FKBP_dom

Uniprot Status Swiss-Prot

Interpro Acc IPR001179

Publications:
TEND: P62942
- Version: 01-August-2011
Alternate Names:

2280 Entrez Gene Id

FKBP1A Gene Symbol

ENSG00000088832 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 5.2.1.8

Publications:

DrugBank: BE0000695

Version: 5.0.8

Alternate Names:

FKBP1A DrugBank Gene Name

P62942 UniProt Accession

2280 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

GuideToPharmacologyInteractions: 2609
- Version: 27-September-2017
Alternate Names:

FK506 binding protein 1A GuideToPharmacology Name

P62942 UniProtKB ID

Gene Info:

Publications:
HingoraniCasas: ENSG00000088832
- Version: 31-May-2017
Alternate Names:

ENSG00000088832 Gene Symbol

FKBP1A Ensembl Id

Gene Info:

Publications:
ChemblInteractions: FKBP1
- Version: chembl_23
Alternate Names:

FKBP12 GENE_SYMBOL

FKBP1A GENE_SYMBOL

Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT

Gene Info:

Publications:
GO: FKBP1A
- Version: 27-September-2017
Alternate Names:

P62942 UniProtKB ID

FKB1A_HUMAN GO Gene Synonym

FKBP1 GO Gene Synonym

Gene Info:

Publications:
TTD: TTDR00122
- Version: 4.3.02 (25-August-2011)
Alternate Names:

PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Gene Synonym

CYCLOSPORIN A-BINDING PROTEIN Gene Synonym

PEPTIDYLPROLYL ISOMERASE Gene Synonym

Gene Info:

Publications:
ClearityFoundationClinicalTrial: FKBP1A
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	LCP-Siro, sirolimus
Novel drug target	Established target
Trial Name	sirolimus, rapamycin,Perceiva

Specific Action of the Ligand	Binding
Endogenous Drug?	False
Direct Interaction?	True

Mechanism of Interaction	FK506-binding protein 1A inhibitor
Direct Interaction	yes

FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942]	Description
ENSG00000088832	Ensembl Gene Id
FKBP1A	Display Id

2280	Entrez Gene Id
FKBP1A	Gene Symbol
ENSG00000088832	Ensembl Gene Id

FKBP1A	DrugBank Gene Name
P62942	UniProt Accession
2280	Entrez Gene Id

FK506 binding protein 1A	GuideToPharmacology Name
P62942	UniProtKB ID

FKBP12	GENE_SYMBOL
FKBP1A	GENE_SYMBOL
Peptidyl-prolyl cis-trans isomerase FKBP1A	UNIPROT

PEPTIDYL-PROLYL CIS-TRANS ISOMERASE	Gene Synonym
CYCLOSPORIN A-BINDING PROTEIN	Gene Synonym
PEPTIDYLPROLYL ISOMERASE	Gene Synonym

inhibitor
other

inhibitor
potentiator

FKBP1A Gene Record

FKBP1A 2280 Druggable Genome

Alternate Names:

Gene Info:

Publications:

Interaction Types: inhibitor

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Interaction Types: inhibitor other

Interaction Info: Trial Name LCP-Siro, sirolimus Novel drug target Established target Trial Name sirolimus, rapamycin,Perceiva

Publications: Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res. Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.

Interaction Types: inhibitor

Interaction Info: Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? True

Publications:

Interaction Types: inhibitor

Interaction Info: Mechanism of Interaction FK506-binding protein 1A inhibitor Direct Interaction yes

Publications:

Interaction Types: inhibitor

Interaction Info: Mechanism of Interaction FK506-binding protein 1A inhibitor Direct Interaction yes

Publications:

Interaction Types: inhibitor

Interaction Info: Mechanism of Interaction FK506-binding protein 1A inhibitor Direct Interaction yes

Publications:

Interaction Types: inhibitor potentiator

Interaction Info: Direct Interaction yes Mechanism of Interaction FK506-binding protein 1A inhibitor

Publications: Reitamo et al., 2002, Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis., Am J Clin Dermatol

Interaction Types: inhibitor

Interaction Info:

Publications:

Interaction Types: inhibitor

Interaction Info:

Publications:

Interaction Types: inhibitor

Interaction Info:

Publications:

Interaction Types: n/a

Interaction Info:

Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Ensembl: ENSG00000088832

Alternate Names: FKBP1A Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING"

Publications:

TdgClinicalTrial: P62942

Alternate Names: FKBP1A Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:5.2.1.8

Publications:

RussLampel: ENSG00000088832

Alternate Names: FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942] Description ENSG00000088832 Ensembl Gene Id FKBP1A Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Publications:

HopkinsGroom: P62942

Alternate Names: ENSG00000088832 Ensembl Gene Id P62942 Uniprot Accession FKB1A_HUMAN Uniprot Id

Gene Info: Interpro Short Name PPIase_FKBP_dom Uniprot Status Swiss-Prot Interpro Acc IPR001179

Publications:

TEND: P62942

Alternate Names: 2280 Entrez Gene Id FKBP1A Gene Symbol ENSG00000088832 Ensembl Gene Id

Gene Info: Target Main Class Enzymes Target Subclass 5.2.1.8

Publications:

DrugBank: BE0000695

Alternate Names: FKBP1A DrugBank Gene Name P62942 UniProt Accession 2280 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

GuideToPharmacologyInteractions: 2609

Alternate Names: FK506 binding protein 1A GuideToPharmacology Name P62942 UniProtKB ID

Gene Info:

Publications:

HingoraniCasas: ENSG00000088832

Alternate Names: ENSG00000088832 Gene Symbol FKBP1A Ensembl Id

Gene Info:

Interaction Types:

inhibitor

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Interaction Types:

inhibitor

other

Interaction Info:

Trial Name LCP-Siro, sirolimus

Novel drug target Established target

Trial Name sirolimus, rapamycin,Perceiva

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.

Interaction Types:

inhibitor

Interaction Info:

Specific Action of the Ligand Binding

Endogenous Drug? False

Direct Interaction? True

Interaction Types:

inhibitor

Interaction Info:

Mechanism of Interaction FK506-binding protein 1A inhibitor

Direct Interaction yes

Interaction Types:

inhibitor

Interaction Info:

Mechanism of Interaction FK506-binding protein 1A inhibitor

Direct Interaction yes

Interaction Types:

inhibitor

Interaction Info:

Mechanism of Interaction FK506-binding protein 1A inhibitor

Direct Interaction yes

Interaction Types:

inhibitor

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction FK506-binding protein 1A inhibitor

Publications:

Reitamo et al., 2002, Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis., Am J Clin Dermatol

Interaction Types:

inhibitor

Interaction Types:

inhibitor

Interaction Types:

inhibitor

Interaction Types:

n/a

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Alternate Names:

FKBP1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING"

Alternate Names:

FKBP1A Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:5.2.1.8

Alternate Names:

FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942] Description

ENSG00000088832 Ensembl Gene Id

FKBP1A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Alternate Names:

ENSG00000088832 Ensembl Gene Id

P62942 Uniprot Accession

FKB1A_HUMAN Uniprot Id

Gene Info:

Interpro Short Name PPIase_FKBP_dom

Uniprot Status Swiss-Prot

Interpro Acc IPR001179

Alternate Names:

2280 Entrez Gene Id

FKBP1A Gene Symbol

ENSG00000088832 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 5.2.1.8

Alternate Names:

FKBP1A DrugBank Gene Name

P62942 UniProt Accession

2280 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Alternate Names:

FK506 binding protein 1A GuideToPharmacology Name

P62942 UniProtKB ID

Alternate Names:

ENSG00000088832 Gene Symbol

FKBP1A Ensembl Id

Alternate Names:

FKBP12 GENE_SYMBOL

FKBP1A GENE_SYMBOL

Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT

Alternate Names:

P62942 UniProtKB ID

FKB1A_HUMAN GO Gene Synonym

FKBP1 GO Gene Synonym

Alternate Names:

PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Gene Synonym

CYCLOSPORIN A-BINDING PROTEIN Gene Synonym

PEPTIDYLPROLYL ISOMERASE Gene Synonym