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FKBP1A Gene Record

categories for FKBP1A
  • Summary
  • Interactions
  • Claims
  • FKBP1A 2280 Druggable Genome

    Alternate Names:

    2280
    FK506 BINDING PROTEIN 1A
    FKBP1A
    FKBP-12
    FKBP-1A
    FKBP1
    FKBP12
    PKC12
    PKCI2
    PPIASE
    186945
    3711
    ENSG00000088832
    OTTHUMG00000031666
    BE0000695
    P62942
    Peptidyl-prolyl cis-trans isomerase FKBP1A
    12 kDa FK506-binding protein
    Calstabin-1
    FK506-binding protein 1A
    Immunophilin FKBP12
    Rotamase
    PPIase FKBP1A
    12 kDa FKBP
    FKB1A_HUMAN
    FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942]
    TTDR00122
    CYCLOPHILIN
    PEPTIDYLPROLYL ISOMERASE
    CYCLOSPORIN A-BINDING PROTEIN
    PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
    2609

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:5.2.1.8
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name PPIase_FKBP_dom
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001179
    Interpro Type Domain
    Interpro Name Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
    Uniprot Evidence 1: Evidence at protein level
    Target Main Class Enzymes
    Target Subclass 5.2.1.8
    Gene Biotype PROTEIN_CODING"
    (8 More Sources)

    Publications:

    Reitamo et al., 2002, Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis., Am J Clin Dermatol
    Labrande et al., 2006, Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa., Neuroscience
    Masri et al., 2007, An assay for the determination of sirolimus levels in the lymphocyte of transplant patients., Transplant. Proc.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
  • TACROLIMUS   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:
    Labrande et al., 2006, Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa., Neuroscience
    Masri et al., 2007, An assay for the determination of sirolimus levels in the lymphocyte of transplant patients., Transplant. Proc.

  • SIROLIMUS   FKBP1A

    Interaction Types:
    inhibitor
    other

    Interaction Info:
    Trial Name LCP-Siro, sirolimus
    Novel drug target Established target
    Trial Name sirolimus, rapamycin,Perceiva

    Publications:
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sehgal, 2003, Sirolimus: its discovery, biological properties, and mechanism of action., Transplant. Proc.

  • ZOTAROLIMUS   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Binding
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • EVEROLIMUS   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction FK506-binding protein 1A inhibitor
    Direct Interaction yes

    Publications:

  • Olocrolimus   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction FK506-binding protein 1A inhibitor
    Direct Interaction yes

    Publications:

  • TEMSIROLIMUS   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction FK506-binding protein 1A inhibitor
    Direct Interaction yes

    Publications:

  • PIMECROLIMUS   FKBP1A

    Interaction Types:
    inhibitor
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction FK506-binding protein 1A inhibitor

    Publications:
    Reitamo et al., 2002, Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis., Am J Clin Dermatol

  • RUCLOSPORIN   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • ALISPORIVIR   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • CHEMBL1269597   FKBP1A

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • CHEMBL110674   FKBP1A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • GPI-1046   FKBP1A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • MYRISTIC ACID   FKBP1A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • CHEMBL1235837   FKBP1A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • DORSOMORPHIN   FKBP1A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • Ensembl: ENSG00000088832

    • Version: 90_38

    Alternate Names:
    FKBP1A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

  • TdgClinicalTrial: P62942

    • Version: January-2014

    Alternate Names:
    FKBP1A Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:5.2.1.8

    Publications:

  • RussLampel: ENSG00000088832

    • Version: 26-July-2011

    Alternate Names:
    FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942] Description
    ENSG00000088832 Ensembl Gene Id
    FKBP1A Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P62942

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000088832 Ensembl Gene Id
    P62942 Uniprot Accession
    FKB1A_HUMAN Uniprot Id

    Gene Info:
    Interpro Short Name PPIase_FKBP_dom
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001179

    Publications:

  • TEND: P62942

    • Version: 01-August-2011

    Alternate Names:
    2280 Entrez Gene Id
    FKBP1A Gene Symbol
    ENSG00000088832 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 5.2.1.8

    Publications:

  • DrugBank: BE0000695

    • Version: 5.0.8

    Alternate Names:
    FKBP1A DrugBank Gene Name
    P62942 UniProt Accession
    2280 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • GuideToPharmacologyInteractions: 2609

    • Version: 27-September-2017

    Alternate Names:
    FK506 binding protein 1A GuideToPharmacology Name
    P62942 UniProtKB ID

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000088832

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000088832 Gene Symbol
    FKBP1A Ensembl Id

    Gene Info:

    Publications:

  • ChemblInteractions: FKBP1

    • Version: chembl_23

    Alternate Names:
    FKBP12 GENE_SYMBOL
    FKBP1A GENE_SYMBOL
    Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT

    Gene Info:

    Publications:

  • GO: FKBP1A

    • Version: 27-September-2017

    Alternate Names:
    P62942 UniProtKB ID
    FKB1A_HUMAN GO Gene Synonym
    FKBP1 GO Gene Synonym

    Gene Info:

    Publications:

  • TTD: TTDR00122

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Gene Synonym
    CYCLOSPORIN A-BINDING PROTEIN Gene Synonym
    PEPTIDYLPROLYL ISOMERASE Gene Synonym

    Gene Info:

    Publications:

  • ClearityFoundationClinicalTrial: FKBP1A

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25