• CDK1 983 Druggable GenomeDrug Resistance

    Alternate Names:

    983
    CYCLIN DEPENDENT KINASE 1
    CDK1
    CDC2
    CDC28A
    P34CDC2
    116940
    1722
    ENSG00000170312
    OTTHUMG00000018290
    1961
    cyclin-dependent kinase 1
    P06493
    NM_001170406
    P40238
    Thrombopoietin receptor
    CDK1_HUMAN
    CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (EC 2.7.1.37) (P34 PROTEIN KINASE) (CYCLIN-DEPENDENT KINASE 1) (CDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06493]
    Cell division protein kinase 1
    Cell division control protein 2 homolog
    CDKN1
    p34 protein kinase
    BE0001082
    CDK 1,2,5,9
    CDK 1,2,4,5,6,7,9 (pan-CDK)

    Gene Info:

    GuideToPharmacology Gene Category Name CDK1 subfamily
    GuideToPharmacology Gene Category ID 492
    GuideToPharmacology Gene Type enzyme
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:2.7.11.22
    Target Subclass 2.7.11.23
    Gene Biotype PROTEIN_CODING"
    Human Readable Name SERINE THREONINE KINASE
    Initial Gene Query CDC2
    Counted Citations from 1950-2000 6569
    Gene Category Kinase
    CancerCommons Reported Gene Name CDK1,2,5,9
    CancerCommons Reported Gene Name Pan CDK
    (13 More Sources)
  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor
    Direct Interaction yes
    Trial Name flavopiridol, alvocidib, HMR-1275

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1 in association with cyclin B
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Types:
    inhibitor
    binder

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex used in assay
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Types:
    inhibitor

    Interaction Info:
    Reported Cancer Type Melanoma
    Details of the Assay for Interaction CDK1/cyclin B complex
    Specific Action of the Ligand Inhibition

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1 in association with cyclin B
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B1 complex.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complexes purified from sf9 cells
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex used in assay
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction CDK1/cyclin B complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor
    Direct Interaction yes
    Details of the Assay for Interaction in association with cyclin B1

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor
    Direct Interaction yes
    Details of the Assay for Interaction CDK1/cyclin B complex

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    binder

    Interaction Info:

  • Interaction Types:
    binder

    Interaction Info:

  • Interaction Types:
    n/a

    Interaction Info:

    • Version: 90_38

    Alternate Names:
    CDK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 25-July-2013

    Alternate Names:
    983 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name CDK1,2,5,9
    CancerCommons Reported Gene Name Pan CDK

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    P06493 Uniprot Accession
    983 Entrez Gene Id
    CDK1 Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level

    Publications:

    • Version: January-2014

    Alternate Names:
    CDC2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.22
    Target Subclass 2.7.11.23

    Publications:

    • Version: 27-June-2013

    Alternate Names:
    983 Entrez Gene Id
    CDK1 Gene Symbol

    Gene Info:
    Human Readable Name SERINE THREONINE KINASE

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (EC 2.7.1.37) (P34 PROTEIN KINASE) (CYCLIN-DEPENDENT KINASE 1) (CDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06493] Description
    CDC2 Display Id
    ENSG00000170312 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    P06493 SwissProt Accession
    cyclin-dependent kinase 1 HUGO Gene Name
    1722 HUGO Gene ID

    Gene Info:
    GuideToPharmacology Gene Category Name CDK1 subfamily
    GuideToPharmacology Gene Category ID 492
    GuideToPharmacology Gene Type enzyme

    Publications:

    • Version: February-2014

    Alternate Names:
    983 Entrez Gene ID

    Gene Info:
    Initial Gene Query CDC2
    Counted Citations from 1950-2000 6569
    Gene Category Kinase

    Publications:

    • Version: 5.0.8

    Alternate Names:
    CDK1 DrugBank Gene Name
    P06493 UniProt Accession
    983 Entrez Gene Id

    Gene Info:

    • Version: 27-September-2017

    Alternate Names:
    cyclin dependent kinase 1 GuideToPharmacology Name
    P06493 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    Thrombopoietin receptor GuideToPharmacology Name
    P40238 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000170312 Gene Symbol
    CDK1 Ensembl Id

    Gene Info:

    Publications:

  • GO: CDK1

    • Version: 27-September-2017

    Alternate Names:
    P06493 UniProtKB ID
    CDK1_HUMAN GO Gene Synonym
    CDC2 GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 20-Jun-2017

    Alternate Names:
    983 Entrez Gene Id
    CDK1 MyCancerGenome Gene Symbol
    CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    CDC28A GENE_SYMBOL
    CDC2 GENE_SYMBOL
    CDKN1 GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications: