• AURKB 9212 Druggable GenomeClinically Actionable

    Alternate Names:

    9212
    AURORA KINASE B
    AURKB
    AIK2
    AIM-1
    AIM1
    ARK-2
    ARK2
    AurB
    IPL1
    PPP1R48
    STK-1
    STK12
    STK5
    aurkb-sv1
    aurkb-sv2
    604970
    11390
    ENSG00000178999
    OTTHUMG00000108189
    BE0003404
    Q96GD4
    AIRK2
    STK1
    AURKB_HUMAN
    SERINE/THREONINE-PROTEIN KINASE 12 (EC 2.7.1.37) (AURORA- AND IPL1- LIKE MIDBODY-ASSOCIATED PROTEIN 1) (AIM-1) (AURORA/IPL1-RELATED KINASE 2) (AURORA-RELATED KINASE 2) (STK-1) (AURORA-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96GD4]
    TTDS00090
    TYROSINE-PROTEIN KINASE RECEPTOR FLT3
    RECEPTOR TYROSINE KINASE FLT3
    STEM CELL TYROSINE KINASE 1
    FL CYTOKINE RECEPTOR
    ENSG00000122025
    2322
    CD135 ANTIGEN
    P36888
    TTDC00139
    AURORA-B
    AURORA- AND IPL1-LIKE MIDBODY-ASSOCIATED PROTEIN 1
    AURORA-2 KINASE
    AURORA/IPL1-RELATED KINASE 2
    AURORA-RELATED KINASE 2
    SERINE/THREONINE PROTEIN KINASE 12
    AURORA-2
    1937
    NP_004208
    NM_001256834
    Serine/threonine-protein kinase 5
    Serine/threonine-protein kinase 12
    Aurora 1
    Serine/threonine-protein kinase aurora-B
    Aurora B
    Aurora A/B/C
    FLT3 TYROSINE KINASE

    Gene Info:

    Source Reported Gene Name AURKB
    Gene Category CLINICALLY ACTIONABLE
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING"
    GuideToPharmacology Gene Category Name Aurora kinase (Aur) family
    GuideToPharmacology Gene Category ID 557
    GuideToPharmacology Gene Type enzyme
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Human Readable Name SERINE THREONINE KINASE
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    (14 More Sources)
  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name SNS-314
    Novel drug target Novel Target
    Notes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name AT9283
    Novel drug target Novel Target
    Notes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name CYC116
    Novel drug target Novel Target
    Notes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor
    Direct Interaction yes
    Notes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name R763, AS703569
    Novel drug target Novel Target
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Direct Interaction? False
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

  • Interaction Types:
    n/a

    Interaction Info:

    • Version: 90_38

    Alternate Names:
    AURKB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    Q96GD4 Uniprot Accession
    9212 Entrez Gene Id
    AURKB_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Status Swiss-Prot

    Publications:

    • Version: 20-September-2013

    Alternate Names:
    9212 Entrez Gene ID

    Gene Info:
    Source Reported Gene Name AURKB
    Gene Category CLINICALLY ACTIONABLE

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000178999 Ensembl Gene Id
    SERINE/THREONINE-PROTEIN KINASE 12 (EC 2.7.1.37) (AURORA- AND IPL1- LIKE MIDBODY-ASSOCIATED PROTEIN 1) (AIM-1) (AURORA/IPL1-RELATED KINASE 2) (AURORA-RELATED KINASE 2) (STK-1) (AURORA-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96GD4] Description
    AURKB Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    11390 HUGO Gene ID
    aurora kinase B HUGO Gene Name
    AURKB Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Aurora kinase (Aur) family
    GuideToPharmacology Gene Category ID 557
    GuideToPharmacology Gene Type enzyme

    Publications:

    • Version: 27-June-2013

    Alternate Names:
    9212 Entrez Gene Id
    AURKB Gene Symbol

    Gene Info:
    Human Readable Name SERINE THREONINE KINASE

    Publications:

    • Version: January-2014

    Alternate Names:
    AURKB Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

    • Version: 5.0.8

    Alternate Names:
    AURKB DrugBank Gene Name
    Q96GD4 UniProt Accession
    9212 Entrez Gene Id

    Gene Info:

    • Version: 27-September-2017

    Alternate Names:
    aurora kinase B GuideToPharmacology Name
    Q96GD4 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000178999 Gene Symbol
    AURKB Ensembl Id

    Gene Info:

    Publications:

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    AURORA- AND IPL1-LIKE MIDBODY-ASSOCIATED PROTEIN 1 Gene Synonym
    AURORA-2 KINASE Gene Synonym
    AURORA/IPL1-RELATED KINASE 2 Gene Synonym

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    Q96GD4 UniProtKB ID
    AURKB_HUMAN GO Gene Synonym
    AIK2 GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 12-May-2016

    Alternate Names:
    AURORA B Gene Symbol

    Gene Info:

    Publications:

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    P36888 Uniprot Accession
    CD135 ANTIGEN Gene Synonym
    2322 Entrez Gene Id

    Gene Info:

    Publications:

    • Version: 20-Jun-2017

    Alternate Names:
    9212 Entrez Gene Id
    AURKB MyCancerGenome Gene Symbol
    Aurora A/B/C MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    AIM1 GENE_SYMBOL
    AIRK2 GENE_SYMBOL
    ARK2 GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications: