• ATR 545 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    545
    ATR SERINE/THREONINE KINASE
    ATR
    FCTCS
    FRP1
    MEC1
    SCKL
    SCKL1
    601215
    882
    ENSG00000175054
    OTTHUMG00000159234
    SERINE-PROTEIN KINASE ATR (EC 2.7.1.37) (ATAXIA TELANGIECTASIA AND RAD3 RELATED PROTEIN) (FRAP-RELATED PROTEIN 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13535]
    FRAP-related protein 1
    Ataxia telangiectasia and Rad3-related protein
    Serine/threonine-protein kinase ATR
    Q13535
    ATR_HUMAN
    1935
    NP_001175
    NM_001184

    Gene Info:

    Gene Biotype PROTEIN_CODING"
    Source Reported Gene Name ATR
    Gene Category CLINICALLY ACTIONABLE
    Human Readable Name SERINE THREONINE KINASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Uniprot Status Swiss-Prot
    Interpro Short Name PI3/4_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name PHOSPHATIDYLINOSITOL 3 KINASE
    Interpro Acc IPR000403
    Interpro Type Domain
    GuideToPharmacology Gene Category Name ATR subfamily
    GuideToPharmacology Gene Category ID 528
    GuideToPharmacology Gene Type enzyme
    (10 More Sources)

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine-protein kinase ATR inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine-protein kinase ATR inhibitor
    Direct Interaction yes
    Details of the Assay for Interaction Inhibition of isolated enzyme

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Drug family PARP inhibitor
    Alteration ATR:.
    Alteration ATR:del

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Drug family Chemotherapy
    Alteration ATR:.

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications:

    • Version: 90_38

    Alternate Names:
    ATR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 20-September-2013

    Alternate Names:
    545 Entrez Gene ID

    Gene Info:
    Source Reported Gene Name ATR
    Gene Category CLINICALLY ACTIONABLE

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    ATR serine/threonine kinase HUGO Gene Name
    882 HUGO Gene ID
    ATR Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name ATR subfamily
    GuideToPharmacology Gene Category ID 528
    GuideToPharmacology Gene Type enzyme

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    SERINE/THREONINE-PROTEIN KINASE ATR Uniprot Protein Name
    ATR Uniprot Gene Name
    ATR_HUMAN Uniprot Id

    Gene Info:
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Uniprot Status Swiss-Prot
    Interpro Short Name PI3/4_kinase_cat_dom

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000175054 Ensembl Gene Id
    SERINE-PROTEIN KINASE ATR (EC 2.7.1.37) (ATAXIA TELANGIECTASIA AND RAD3 RELATED PROTEIN) (FRAP-RELATED PROTEIN 1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13535] Description
    ATR Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 27-June-2013

    Alternate Names:
    545 Entrez Gene Id
    ATR Gene Symbol

    Gene Info:
    Human Readable Name SERINE THREONINE KINASE

    Publications:

  • NCI: ATR

    • Version: 14-September-2017
    • Version: 27-September-2017

    Alternate Names:
    ATR serine/threonine kinase GuideToPharmacology Name
    Q13535 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000175054 Gene Symbol
    ATR Ensembl Id

    Gene Info:

    Publications:

  • GO: ATR

    • Version: 27-September-2017

    Alternate Names:
    Q13535 UniProtKB ID
    ATR_HUMAN GO Gene Synonym
    FRP1 GO Gene Synonym

    Gene Info:

    Publications:

    • Version: chembl_23

    Alternate Names:
    FRP1 GENE_SYMBOL
    ATR GENE_SYMBOL
    Serine/threonine-protein kinase ATR UNIPROT

    Gene Info:

    Publications:

  • CGI: ATR

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications: