• AKT3 10000 Druggable GenomeClinically Actionable

    Alternate Names:

    10000
    AKT SERINE/THREONINE KINASE 3
    AKT3
    MPPH
    MPPH2
    PKB-GAMMA
    PKBG
    PRKBG
    RAC-PK-gamma
    RAC-gamma
    STK-2
    611223
    393
    ENSG00000117020
    OTTHUMG00000039994
    AKT3_HUMAN
    Q9Y243
    RAC-gamma serine/threonine-protein kinase
    PKB gamma
    Protein kinase B gamma
    Protein kinase Akt-3
    2286
    7936
    NP_005456
    NM_005465
    v-akt murine thymoma viral oncogene homolog 3
    RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-GAMMA) (PROTEIN KINASE AKT-3) (PROTEIN KINASE B, GAMMA) (PKB GAMMA) (STK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y243]

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Gene Biotype PROTEIN_CODING"
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Source Reported Gene Name AKT3
    Gene Category CLINICALLY ACTIONABLE
    Human Readable Name SERINE THREONINE KINASE
    GuideToPharmacology Gene Category Name Akt (Protein kinase B)
    GuideToPharmacology Gene Category ID 285
    GuideToPharmacology Gene Type enzyme
    (12 More Sources)
  • Interaction Types:
    inhibitor
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Negative

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT3 inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name XL418
    Novel drug target Novel Target
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    combination therapy [AZD5363,GSK2141795]
    Drug family [ATP competitive AKT inhibitor]
    Alteration AKT3__.

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    Publications:

  • Interaction Types:
    inhibitor
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Alteration AKT3__.
    combination therapy [AZD5363,GSK2141795]
    Drug family [ATP competitive AKT inhibitor]

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    inhibitor

    Interaction Info:

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name perifosine, KRX-0401
    Novel drug target Novel Target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:
    Trial Name triciribine-phosphate, TCN-P, VQD-002
    Novel drug target Novel Target

    Publications:

  • Interaction Types:
    n/a

    Interaction Info:

    Publications:

    • Version: 90_38

    Alternate Names:
    AKT3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING"

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000117020 Ensembl Gene Id
    AKT3_HUMAN Uniprot Id
    AKT3 Uniprot Gene Name

    Gene Info:
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

    Publications:

    • Version: 4-March-2015

    Alternate Names:
    v-akt murine thymoma viral oncogene homolog 3 HUGO Gene Name
    393 HUGO Gene ID
    AKT3 Gene Symbol

    Gene Info:
    GuideToPharmacology Gene Category Name Akt (Protein kinase B)
    GuideToPharmacology Gene Category ID 285
    GuideToPharmacology Gene Type enzyme

    Publications:

    • Version: 20-September-2013

    Alternate Names:
    10000 Entrez Gene ID

    Gene Info:
    Source Reported Gene Name AKT3
    Gene Category CLINICALLY ACTIONABLE

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-GAMMA) (PROTEIN KINASE AKT-3) (PROTEIN KINASE B, GAMMA) (PKB GAMMA) (STK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y243] Description
    AKT3 Display Id
    ENSG00000117020 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Publications:

    • Version: 27-June-2013

    Alternate Names:
    10000 Entrez Gene Id
    AKT3 Gene Symbol

    Gene Info:
    Human Readable Name SERINE THREONINE KINASE

    Publications:

    • Version: January-2014

    Alternate Names:
    AKT3 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

    • Version: 27-September-2017
    • Version: chembl_23

    Alternate Names:
    PKBG GENE_SYMBOL
    AKT3 GENE_SYMBOL
    RAC-gamma serine/threonine-protein kinase UNIPROT

    Gene Info:

    Publications:

  • GO: AKT3

    • Version: 27-September-2017

    Alternate Names:
    Q9Y243 UniProtKB ID
    AKT3_HUMAN GO Gene Synonym
    PKBG GO Gene Synonym

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000117020 Gene Symbol
    AKT3 Ensembl Id

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:
    AKT serine/threonine kinase 3 GuideToPharmacology Name
    Q9Y243 UniProtKB ID

    Gene Info:

    Publications:

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications: