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SULFASALAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • SULFASALAZINE CHEMBL421 FDA Approved

    Alternate Names:

    Salazopyrin-En
    Salazopyrin E.C.
    Ucine
    Sulfasalazine
    Colizine
    Salicylazosulfapyridine
    Salazosulfapyridine
    Sulphasalazine
    Azulfidine
    S.A.S.
    Azulfidine EN
    Salazopyrin
    SAS-500
    S.A.S.-500
    Azulfidine EN-Tabs
    C29469
    Sulcolon
    Zopyrin
    Weiliufen
    Sulfasalazine Delayed-release
    Sulfacol
    Sas Tab 500mg
    Sas Enema 3gm/100ml
    Salazopyrin Tab 500mg
    Salazopyrin Enema 3gm/100ml
    Salazopyrin Enema 3.0gm/100ml
    Salazopyrin En-tabs 500 mg
    Salazopyrin EN-Tabs
    Salazopyrin EN
    Salazoprin
    Salazopirina
    Salazine
    Salazidin
    Salazar
    Salasopyrine
    Saaz-DS
    Saaz
    S.A.S. Enteric 500mg
    Reumazin
    Ratio-sulfasalazine Tab 500mg
    Ratio-sulfasalazine En
    Pyralin EN
    Pleon
    PMS-sulfasalazine-E.C. Tab 500mg
    PMS-sulfasalazine 500mg/tab USP
    Orb-sulfasalazine EC
    Lazafin
    Lanofen
    Iwata
    Flogostop
    Eminapyrin
    Disalazin
    Colo-Pleon
    Bomecon
    Azulfin
    Azulfdidina
    Asasurfan
    Apo Sulfasalazine Tab 500mg
    599-79-1
    Salazosulfapyridinum
    Salazosulfapiridina
    Azopyrin
    5-(P-(2-Pyridylsulfamyl)phenylazo)salicylic acid
    5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid
    5-((P-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid
    4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene
    2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid
    2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid
    DB00795
    W-T SASP ORAL
    NCGC00016518-01
    BRN 0356241
    WLN: T6NJ BSWMR DNUNR DQ CVQ
    NSC203730
    EINECS 209-974-3
    SI-88
    HMS1569H21
    SALAZOSULFAPIRIDINA [INN-SPANISH]
    SALAZOSULFAPYRIDINUM [INN-LATIN]
    HSDB 3395
    CHEMBL242373
    CCRIS 4713
    BIDD:GT0161
    CAS-599-79-1
    SULFASALAZINA [INN-SPANISH]
    NCGC00090903-01
    AZULFADINE
    SULFASALAZINUM [INN-LATIN]
    AC1Q72VB
    S.A.S. ENTERIC-500
    S.A.S. 500
    SULFASALAZINE (USP/INN)
    AC1NSE0P
    PMS-SULFASALAZINE E.C.
    13GS
    SALAZO-SULFAPYRIDINUM
    SULPHASALAZINE, N-
    PRESTWICK_848
    AZLUFIDINE EN-TABS
    AZULFIDINE (TN)
    PMS-SULFASALAZINE
    ALTI-SULFASALAZINE
    UNII-3XC8GUZ6CB
    SULFAZALAZINE
    AZOSULFIDIN
    SALAZOSULFAPYRIDIN
    BENZOSULFA
    AZOPYRINE
    SULFASALAZINUM
    SULFASALAZINA
    SALAZOPYRIDIN
    SALAZOPIRIDAZIN
    5359476
    SULFASALAZIN
    SALISULF
    REUPIRIN
    2-?HYDROXY-?5-?[2-?[4-?[(2-?PYRIDINYLAMINO)SULFONYL]PHENYL]DIAZENYL]-?BENZOIC ACID
    (3Z)-6-OXO-3-(2-{4-[(PYRIDIN-2-YL)SULFAMOYL]PHENYL}HYDRAZIN-1-YLIDENE)CYCLOHEXA-1,4-DIENE-1-CARBOXYLIC ACID
    (3E)-6-OXO-3-[[4-(PYRIDIN-2-YLSULFAMOYL)PHENYL]HYDRAZINYLIDENE]CYCLOHEXA-1,4-DIENE-1-CARBOXYLIC ACID
    (3E)-6-OXO-3-[[4-(2-PYRIDYLSULFAMOYL)PHENYL]HYDRAZONO]CYCLOHEXA-1,4-DIENE-1-CARBOXYLIC ACID
    2-HYDROXY-5-((4-[(2-PYRIDINYLAMINO)SULFONYL]PHENYL)DIAZENYL)BENZOIC ACID #
    2-HYDROXY-5-[(E)-[4-(2-PYRIDYLSULFAMOYL)PHENYL]AZO]BENZOIC ACID
    SULPHASALAZINE, ANTIBIOTIC FOR CULTURE MEDIA USE ONLY
    5-[[4-(2-PYRIDYLSULFAMOYL)PHENYL]AZO]SALICYLIC ACID
    Q-201769
    3B2-0009
    AB00052101-06
    AB00052101-04
    J10488
    AB0013330
    HY-14655
    HE270326
    H881
    DR002328
    AK163126
    NSC-757330
    NSC-667219
    NC00237
    MCULE-7533021815
    HS-0062
    CS-2145
    CCG-100987
    AN-8097
    ZINC14768602
    NSC757330
    DL-510
    CCG-39145
    PHARMAKON1600-01500552
    HMS2232H07
    HMS2096H21
    NCEXYHBECQHGNR-QZQOTICOSA-N
    BENZOIC ACID, 2-HYDROXY-5-((4-((2-PYRIDINYLAMINO)SULFONYL)PHENYL)AZO)-
    2-HYDROXY-5-({4-[(2-PYRIDYLAMINO)SULFONYL]PHENYL}DIAZENYL)BENZOIC ACID
    CHEMBL100848
    SCHEMBL18490
    5-[4-(2-PYRIDYLSULFAMOYL)-PHENYLAZO]-SALICYLIC ACID
    TL8003811
    SMR000059146
    AC-20497
    SMP2_000059
    IDI1_000860
    NSC 203730
    DB08518
    BENZOIC ACID, 2-HYDROXY-5-[[4-[(2-PYRIDINYLAMINO)SULFONYL]PHENYL]AZO]-
    AKOS002311709
    HMS2092K07
    HMS2090P13
    HMS2051J21
    6-OXO-3-[[4-(PYRIDIN-2-YLSULFAMOYL)PHENYL]HYDRAZINYLIDENE]CYCLOHEXA-1,4-DIENE-1-CARBOXYLIC ACID
    2-HYDROXY-5-[(E)-2-{4-[(PYRIDIN-2-YL)SULFAMOYL]PHENYL}DIAZEN-1-YL]BENZOIC ACID
    (E)-2-HYDROXY-5-((4-(N-(PYRIDIN-2-YL)SULFAMOYL)PHENYL)DIAZENYL)BENZOIC ACID
    F2173-1125
    SMR004703430
    KB-79573
    HE066686
    NCGC00186644-01
    NCGC00090903-09
    ZINC100031653
    AKOS025116975
    ANW-43676
    ZINC3831490
    HMS3393J21
    HMS3370D16
    NCEXYHBECQHGNR-UHFFFAOYSA-N
    CTK8B4012
    CHEMBL3186737
    2-HYDROXY-5-[[4-[(2-PYRIDINYLAMINO)SULFONYL]PHENYL]AZO]BENZOIC ACID
    GTPL4840
    MLS006011702
    SCHEMBL4514
    EPITOPE ID:122672
    SALAZOPYRIDINREG
    SALAZOPYRINREG
    AZULFIDINEREG
    SSZ
    SULFASALAZINE-D4
    SBB058178
    5384001
    (Z)-6-OXO-3-(2-(4-(N-(PYRIDIN-2-YL)SULFAMOYL)PHENYL)HYDRAZONO)CYCLOHEXA-1,4-DIENE-1-CARBOXYLIC ACID
    4-(PYRIDYL-2-AMIDOSULFONYL)-3''-CARBOXY-4''-HYDROXYAZOBENZENE
    FT-0603483
    TR-020767
    AB2000147
    NCGC00258791-01
    NCGC00254313-01
    NCGC00090903-11
    NCGC00090903-07
    NCGC00090903-06
    VA11798
    NSC-203730
    CID5384001
    CID5353980
    ZINC100030102
    TOX21_111037_1
    KM0360
    DCL001005
    DAP000153
    BDBM50097125
    TOX21_300541
    TOX21_201239
    TOX21_111037
    AZULFIDINE;SALAZOPYRIN;SULPHASALAZINE
    CHEBI:489907
    CHEBI:45504
    SCHEMBL10289061
    2-HYDROXY-5-(4-[(PYRIDIN-2-YLAMINO)SULFONYL]PHENYL}DIAZENYL)BENZOIC ACID
    SCHEMBL1229516
    SCHEMBL1079598
    D012460
    SALAZOSULFAPYRIDINE (JP16)
    SALAZOSULFAPYRIDINE (JP15)
    SCHEMBL4515
    5-(PARA-(2-PYRIDYLSULFAMOYL)PHENYLAZO)SALICYLIC ACID
    HE307458
    3XC8GUZ6CB
    SANOFI SYNTHELABO BRAND OF SULFASALAZINE
    NCHEMBIO.212-COMP9
    CID5359476
    HENNING BERLIN BRAND OF SULFASALAZINE
    RATIOPHARM BRAND OF SULFASALAZINE
    ALPHAPHARM BRAND OF SULFASALAZINE
    ASHBOURNE BRAND OF SULFASALAZINE
    PFIZER BRAND OF SULFASALAZINE
    LS-46
    SULFASALIZINE
    MEDAC BRAND OF SULFASALAZINE
    HEYL BRAND OF SULFASALAZINE
    FNA BRAND OF SULFASALAZINE
    SULFASALAZINE PFIZER BRAND
    5-[[P-(2-PYRIDYLSULFAMOYL)PHENYL]AZO]SALICYLIC ACID
    5-[4-(2-PYRIDYLSULFAMOYL)PHENYLAZO]SALICYLIC ACID
    SULFASALAZINE [USAN:INN]
    (3Z)-6-OXO-3-[[4-(PYRIDIN-2-YLSULFAMOYL)PHENYL]HYDRAZINYLIDENE]CYCLOHEXA-1,4-DIENE-1-CARBOXYLIC ACID
    RATIO-SULFASALAZINE
    RATIO SULFASALAZINE
    AC1NTMDP
    2-HYDROXY-5-[(E)-{4-[(PYRIDIN-2-YLAMINO)SULFONYL]PHENYL}DIAZENYL]BENZOIC ACID
    SULFASALAZINE FNA
    SULFASALAZIN MEDAC
    EN, AZULFIDINE
    SULFASALAZIN-HEYL
    SULFASALAZIN HEYL
    SALAZOPYRIN EN-TABS
    COLO PLEON
    ULCOL
    SALICYLIC ACID, 5-[[P-(2-PYRIDYLSULFAMOYL)PHENYL]AZO]-
    SALICYLIC ACID, 5-((P-(2-PYRIDYLSULFAMOYL)PHENYL)AZO)-
    I06-0676
    BRD-K10670311-001-06-4
    5-(P-(2-PYRIDINYLSULFAMOYL)PHENYLAZO)SALICYLIC ACID
    5-22-08-00433 (BEILSTEIN HANDBOOK REFERENCE)
    5-[P-(2-PYRIDYLSULFAMOYL)PHENYLAZO]SALICYLIC ACID
    DSSTOX_GSID_21256
    5-[P-(2-PYRIDYLSULFAMYL)PHENYLAZO]SALICYLIC ACID
    DSSTOX_RID_76043
    D00448
    C07316
    2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID
    DSSTOX_CID_1256
    2-HYDROXY-5-{[4-(PYRIDIN-2-YLSULFAMOYL)PHENYL]DIAZENYL}BENZOIC ACID
    S0580
    SAM001246530
    CPD000059146
    NCGC00090903-05
    NCGC00090903-04
    NCGC00090903-03
    NCGC00090903-02
    HMS1921C05
    NINDS_000860
    MOLPORT-003-986-992
    MOLPORT-001-792-507
    CMAP_000018
    KBIO3_002794
    KBIO3_002108
    KBIO2_007450
    KBIO2_006614
    KBIO2_004882
    KBIO2_004046
    KBIO2_002314
    KBIO2_001478
    KBIO1_000860
    HMS502K22
    C18H14N4O5S
    CHEBI:9334
    BPBIO1_000527
    SPBIO_002400
    SPBIO_001032
    SPECTRUM1500552
    DIVK1C_000860
    MLS001424109
    MLS000759399
    KBIOSS_002316
    KBIOSS_001478
    KBIOGR_002314
    KBIOGR_000753
    BSPBIO_002888
    BSPBIO_000479
    SPECTRUM5_001443
    SPECTRUM4_000347
    SPECTRUM3_001364
    SPECTRUM2_001216
    PRESTWICK3_000520
    PRESTWICK2_000520
    PRESTWICK1_000520
    PRESTWICK0_000520
    AC1NS4RK
    SPECTRUM_000998
    NSC 667219
    SASP
    ST50767935
    NSC667219
    ACCUCOL
    ASULFIDINE
    5353980
    48425604
    9524
    46505451
    C1CCNC(C1)NS(=O)(=O)C2CCC(CC2)N=NC3CCC(C(C3)C(=O)O)O
    0013-0102-01
    PA451547
    SAS
    RORASUL
    685933
    4510284
    9334
    178101542
    4840
    BAY-299
    1346606-50-5
    2-HYDROXY-5-[[4-[(2-PYRIDINYLAMINO-D4)SULFONYL]PHENYL]AZO]BENZOIC ACID
    5-[[P-(2-PYRIDYLSULFAMOYL-D4)PHENYL]AZO]SALICYLIC ACID
    5-[P-(2-PYRIDYLSULFAMYL-D4)PHENYLAZO]SALICYLIC ACID
    SALICYLAZOSULFAPYRIDINE-D4
    SALAZOSULFAPYRIDINE-D4
    SALAZOSULFAPYRIDIN-D4
    AZULFIDINE EN-D4
    COLO-PLEON-D4
    SULPHASALAZINE-D4
    SALISULF-D4
    REUPIRIN-D4
    AZOPYRIN-D4
    SALAZOPYRIDIN-D4
    AZOPYRINE-D4
    BENZOSULFA-D4
    AZULFIDINE-D4
    SALAZOPYRIN-D4
    SULFASALAZIN-D4
    SALAZOPYRINE-D4
    71752289

    Drug Info:

    Drug Categories therapeutic uses
    Drug Categories sulfur compounds
    Drug Categories sulfones
    Drug Categories sulfonamides
    Drug Categories sensory system agents
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories peripheral nervous system agents
    Drug Categories organic chemicals
    Drug Categories intestinal antiinflammatory agents
    Drug Categories inorganic chemicals
    Drug Categories gastrointestinal agents
    Drug Categories chemical actions and uses
    Drug Categories central nervous system agents
    Drug Categories bcrp/abcg2 substrates
    Drug Categories bcrp/abcg2 inhibitors
    Drug Categories antirheumatic agents
    Drug Categories antidiarrheals, intestinal antiinflammatory/antiinfective agents
    Drug Categories anti-inflammatory agents, non-steroidal
    Drug Categories anti-inflammatory agents
    Drug Categories anti-infective agents
    Drug Categories analgesics, non-narcotic
    Drug Categories analgesics
    Drug Categories aminosalicylic acid and similar agents
    Drug Categories amides
    Drug Categories alimentary tract and metabolism
    Drug Groups approved
    Drug Type small molecule
    Year of Approval 1950
    Drug Class anti-inflammatory agents, non-steroidal
    Drug Class antirheumatic agents
    ATC a07ec(aminosalicylic acid and similar agents)
    Drug Type drug/small molecule
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiinflammatory agent,DMARD
    (9 More Sources)

    Publications:

    Sircar et al., 1983, Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis., Biochem. Pharmacol.
    Nielsen et al., 1987, Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid., Dig. Dis. Sci.
    Allgayer et al., 1984, Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine., Eur. J. Clin. Pharmacol.
    Cipolla et al., 2002, Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives., Pharmacol. Res.
    Pruzanski et al., 1997, Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity., Biochem. Pharmacol.
    Generini et al., Therapy of spondylarthropathy in inflammatory bowel disease., Clin. Exp. Rheumatol.
    Mifflin et al., 2004, Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts., Mol. Pharmacol.
    Distrutti et al., 2006, 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity., J. Pharmacol. Exp. Ther.
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
    Schwab et al., 2008, PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells., Carcinogenesis
    Desreumaux et al., 2006, Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence., Aliment. Pharmacol. Ther.
    Linard et al., 2008, Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist., J. Pharmacol. Exp. Ther.
    Rousseaux et al., 2005, Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma., J. Exp. Med.
    Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Gout et al., 2001, Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug., Leukemia
    Faison et al., 1992, Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase., Prostaglandins
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Stenson et al., 1983, Inhibition of platelet thromboxane synthetase by sulfasalazine., Biochem. Pharmacol.
    Matasić et al., 2001, Maturation of human dendritic cells as sulfasalazine target., Croat. Med. J.
    Selhub et al., 1978, Inhibition of folate enzymes by sulfasalazine., J. Clin. Invest.
    Morabito et al., 1998, Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides., J. Clin. Invest.
    de Bruin et al., 2004, Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells., Mol. Pharmacol.
  • SULFASALAZINE   PTGS1

    Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name sulfasalazine,Azulfidine, Salazopyrin
    Novel drug target Established target
    Mechanism of Interaction Cyclooxygenase inhibitor

    Publications:
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.

  • SULFASALAZINE   BRD1

    Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction In a <i>BROMOscan&reg;</i> assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • SULFASALAZINE   TAF1

    Interaction Types:
    inhibitor

    Interaction Info:
    Details of the Assay for Interaction In a <i>BROMOscan&reg;</i> assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    Publications:

  • SULFASALAZINE   ALOX5

    Interaction Types:
    inhibitor

    Interaction Info:
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor
    Direct Interaction yes

    Publications:
    Sircar et al., 1983, Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis., Biochem. Pharmacol.
    Nielsen et al., 1987, Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid., Dig. Dis. Sci.
    Allgayer et al., 1984, Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine., Eur. J. Clin. Pharmacol.

  • SULFASALAZINE   PTGS2

    Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name sulfasalazine,Azulfidine, Salazopyrin
    Novel drug target Established target
    Mechanism of Interaction Cyclooxygenase inhibitor

    Publications:
    Cipolla et al., 2002, Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives., Pharmacol. Res.
    Pruzanski et al., 1997, Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity., Biochem. Pharmacol.
    Generini et al., Therapy of spondylarthropathy in inflammatory bowel disease., Clin. Exp. Rheumatol.

  • SULFASALAZINE   PPARG

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name sulfasalazine,Azulfidine, Salazopyrin
    Novel drug target Established target

    Publications:
    Schwab et al., 2008, PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells., Carcinogenesis
    Desreumaux et al., 2006, Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence., Aliment. Pharmacol. Ther.
    Linard et al., 2008, Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist., J. Pharmacol. Exp. Ther.

  • SULFASALAZINE   CHUK

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:
    Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.

  • SULFASALAZINE   IKBKB

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:
    Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.

  • SULFASALAZINE   SLC7A11

    Interaction Types:
    inhibitor

    Interaction Info:

    Publications:
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Gout et al., 2001, Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug., Leukemia

  • SULFASALAZINE   ACAT1

    Interaction Types:
    inhibitor

    Interaction Info:
    Trial Name sulfasalazine,Azulfidine, Salazopyrin
    Novel drug target Established target

    Publications:
    Faison et al., 1992, Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase., Prostaglandins
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • SULFASALAZINE   TBXAS1

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Stenson et al., 1983, Inhibition of platelet thromboxane synthetase by sulfasalazine., Biochem. Pharmacol.

  • SULFASALAZINE   PLA2G1B

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Pruzanski et al., 1997, Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity., Biochem. Pharmacol.

  • SULFASALAZINE   NFKB2

    Interaction Types:
    activator

    Interaction Info:

    Publications:

  • SULFASALAZINE   CD83

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Matasić et al., 2001, Maturation of human dendritic cells as sulfasalazine target., Croat. Med. J.

  • SULFASALAZINE   DHFR

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Selhub et al., 1978, Inhibition of folate enzymes by sulfasalazine., J. Clin. Invest.

  • SULFASALAZINE   NT5E

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Morabito et al., 1998, Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides., J. Clin. Invest.

  • SULFASALAZINE   TYMP

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    de Bruin et al., 2004, Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells., Mol. Pharmacol.

  • SULFASALAZINE   G6PD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • SULFASALAZINE   ENOSF1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • SULFASALAZINE   TYMSOS

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • SULFASALAZINE   SLC19A1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • SULFASALAZINE   TYMS

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • SULFASALAZINE   MTR

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • DrugBank: DB00795

    • Version: 5.0.8

    Alternate Names:
    SULFASALAZINE DrugBank Drug Name
    2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid Drug Synonym
    2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid Drug Synonym

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories alimentary tract and metabolism

    Publications:
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
    Faison et al., 1992, Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase., Prostaglandins
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • TEND: SULFASALAZINE

    • Version: 01-August-2011

    Alternate Names:
    SULFASALAZINE Primary Drug Name

    Drug Info:
    Drug Class anti-inflammatory agents, non-steroidal
    Year of Approval 1950
    Drug Class antirheumatic agents

    Publications:

  • PharmGKB: PA451547

    • Version: 12-July-2012

    Alternate Names:
    SALAZOPIRIDAZIN Drug Trade Name
    SALAZOPYRIDIN Drug Trade Name
    SALICYLAZOSULFAPYRIDINE Drug Trade Name

    Drug Info:
    Drug Type drug/small molecule
    ATC a07ec(aminosalicylic acid and similar agents)

    Publications:

  • TdgClinicalTrial: SULFASALAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent,DMARD
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: SULFASALAZINE

    • Version: 14-September-2017

    Alternate Names:
    C29469 NCI drug code

    Drug Info:

    Publications:
    Selhub et al., 1978, Inhibition of folate enzymes by sulfasalazine., J. Clin. Invest.
    Morabito et al., 1998, Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides., J. Clin. Invest.
    Matasić et al., 2001, Maturation of human dendritic cells as sulfasalazine target., Croat. Med. J.

  • PubChem: SULFASALAZINE-D4

    • Version: 09-Feb-2016

    Alternate Names:
    SULFASALAZINE-D4 pubchem_primary_name
    71752289 PubChem CID
    SALAZOPYRINE-D4 Drug Synonym

    Drug Info:

    Publications:

  • PubChem: SULFASALAZINE

    • Version: 09-Feb-2016

    Alternate Names:
    SULFASALAZINE pubchem_primary_name
    5353980 PubChem CID
    SULPHASALAZINE Drug Synonym

    Drug Info:

    Publications:

  • GuideToPharmacologyInteractions: 9524

    • Version: 27-September-2017

    Alternate Names:
    BAY-299 GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: DAP000153

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    HMS502K22 Drug Synonym
    KBIO3_002794 Drug Synonym
    599-79-1 CAS Number

    Drug Info:

    Publications:

  • TTD: DCL001005

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    5359476 Pubchem CId
    48425604 Pubchem SId
    SULFASALIZINE Primary Drug Name

    Drug Info:

    Publications:

  • GuideToPharmacologyInteractions: 4840

    • Version: 27-September-2017

    Alternate Names:
    SULFASALAZINE GuideToPharmacology Ligand Name
    178101542 PubChem Drug SID

    Drug Info:

    Publications:

  • FDA: Sulfasalazine

    • Version: 15-September-2017

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL421

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25