• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • Getting Started API Documentation FAQ News Contact
    • Downloads
      • Data Source Code

RIZATRIPTAN Drug Record

  • Summary
  • Interactions
  • Claims
  • RIZATRIPTAN CHEMBL905 FDA Approved

    Alternate Names:

    Rizatriptan
    Maxalt
    Maxalt-Mlt
    MK-462
    MK 462 FREE BASE
    RIZATRIPTANUM
    BIDD:GT0361
    RIZATRIPTAN (INN)
    MOLPORT-003-666-600
    AC1L1JK9
    1H-INDOLE-3-ETHANAMINE, N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-
    N,N-DIMETHYL-2-[5-(1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]-ETHANAMINE
    UNII-51086HBW8G
    RIZATRIPTAN BENZOAT
    5078
    144034-80-0
    CHEBI:48273
    N,N-DIMETHYL-2-[5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHANAMINE
    LS-83053
    SPECTRUM1505189
    NCGC00095899-01
    TL8000966
    DB00953
    AC-1712
    RISATRIPTAN
    N,N-DIMETHYL-2-[5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHYLAMINE
    7854588
    L000812
    C093622
    N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE
    D08485
    N,N-DIMETHYL-2-[5-(1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHANAMINE
    145202-66-0
    RIZATRIPTAN [INN:BAN]
    DAP000220
    CID5078
    I06-2272
    Van-rizatriptan ODT
    Van-rizatriptan
    Teva-rizatriptan ODT
    Teva-rizatriptan
    Sandoz Rizatriptan ODT
    Rizatriptan Rdt
    Rizatriptan ODT
    Rizaport
    Riva-rizatriptan ODT
    Q-rizatriptan ODT
    PMS-rizatriptan Rdt
    Nat-rizatriptan ODT
    Nat-rizatriptan
    Mylan-rizatriptan ODT
    Mylan-rizatriptan
    Mint-rizatriptan ODT
    Maxalt Rpd
    Maxalt MLT
    Mar-rizatriptan
    Jamp-rizatriptan Ir
    Jamp-rizatriptan
    Ipg-rizatriptan
    Dom-rizatriptan Rdt
    Auro-rizatriptan ODT
    Auro-rizatriptan
    Apo-rizatriptan Rpd
    Apo-rizatriptan
    Act Rizatriptan ODT
    Act Rizatriptan
    178101771
    FAS LIGAND
    FASLG
    DIMETHYL-[2-(5-[1,2,4]TRIAZOL-1-YLMETHYL-1H-INDOL-3-YL)-ETHYL]-AMINE
    Q-201675
    3B2-6282
    A808161
    AB00698277-07
    AB00698277-05
    S-5530
    CAS-144034-80-0
    4CH-007687
    ST2409343
    KB-300182
    SMR000469172
    SC-17974
    LP074528
    DR000842
    BR-72890
    BC201784
    AK-72890
    AJ-08257
    NCGC00095899-04
    RL01798
    AN-5270
    AKOS015896596
    FC0031
    BDBM50033437
    TOX21_111534
    ZINC5895
    IND062
    MLS006010229
    CC-317
    SCHEMBL26662
    DSSTOX_GSID_23565
    DSSTOX_RID_77082
    GTPL51
    DSSTOX_CID_3565
    PUBCHEM16714
    RIZATRIPTAN;
    MAXALTREG
    MK-A462
    DIMETHYL({2-[5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHYL})AMINE
    ULFRLSNUDGIQQP-UHFFFAOYSA-N
    2-(5-((1H-1,2,4-TRIAZOL-1-YL)METHYL)-1H-INDOL-3-YL)-N,N-DIMETHYLETHANAMINE
    51086HBW8G
    135650905
    51
    C1538
    FAS-LIGAND

    Drug Info:

    Drug Class anti-migraine agents
    Year of Approval 1998
    Drug Categories serotonin receptor agonists
    Drug Categories serotonin modulators
    Drug Categories serotonin agents
    Drug Categories serotonin 5-ht1 receptor agonists
    Drug Categories selective serotonin (5ht1) agonists
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories organic chemicals
    Drug Categories neurotransmitter agents
    Drug Categories nervous system
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories migraine disorders
    Drug Categories indoles
    Drug Categories heterocyclic compounds, 2-ring
    Drug Categories heterocyclic compounds, 1-ring
    Drug Categories heterocyclic compounds
    Drug Categories cytochrome p-450 cyp1a2 substrates
    Drug Categories chemical actions and uses
    Drug Categories biogenic monoamines
    Drug Categories biogenic amines
    Drug Categories azoles
    Drug Categories antimigraine preparations
    Drug Categories analgesics
    Drug Categories amines
    Drug Groups approved
    Drug Type small molecule
    Name of the Ligand Species (if a Peptide) Human
    FDA Approval 1998
    Drug Class small molecule
    Drug Indications Anti-migraine Agents
    (5 More Sources)

    Publications:

    Ikemoto et al., 2004, [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance]., Nippon Yakurigaku Zasshi
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Longmore et al., Comparison of the vasoconstrictor properties of the 5-HT1D-receptor agonists rizatriptan (MK-462) and sumatriptan in human isolated coronary artery: outcome of two independent studies using different experimental protocols., Funct. Neurol.
    Longmore et al., 1996, 5-HT1D receptor agonists and human coronary artery reactivity in vitro: crossover comparisons of 5-HT and sumatriptan with rizatriptan and L-741,519., Br J Clin Pharmacol
    Williamson et al., 2001, The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs., Br. J. Pharmacol.
    Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
    Sciberras et al., 1997, Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist., Br J Clin Pharmacol
    Wellington et al., 2002, Spotlight on rizatriptan in migraine., CNS Drugs
    Wellington et al., 2002, Rizatriptan: an update of its use in the management of migraine., Drugs
    Pauwels et al., 1998, Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors: intrinsic activity and modulation by G-protein activation state., Naunyn Schmiedebergs Arch. Pharmacol.
    Villalón et al., 2002, An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy., Proc. West. Pharmacol. Soc.
    Goadsby et al., 2003, Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input., Neuroscience
    Wainscott et al., 1998, Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation., Eur. J. Pharmacol.
    Villalón et al., 2003, Migraine: pathophysiology, pharmacology, treatment and future trends., Curr Vasc Pharmacol
    Villunger et al., 2000, Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes., J. Exp. Med.
    Yu et al., 2003, Synergism of Fas-mediated apoptosis and tumor necrosis factor on adriamycin cytotoxicity to transitional cell carcinoma., Urol. Int.
    Srivastava et al., 1999, Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription., J. Exp. Med.
    Tagami et al., Fas-mediated apoptosis in acute alcoholic hepatitis., Hepatogastroenterology
    da Rocha Dias et al., 2001, CTLA-4 blockade of antigen-induced cell death., Blood
    Wakao et al., 2000, Involvement of granzyme B expression in the enhancement of natural killer activity by beta-endorphin., Brain Behav. Immun.
    Kawano et al., 2002, Decreased akt activity is associated with activation of forkhead transcription factor after transient forebrain ischemia in gerbil hippocampus., J. Cereb. Blood Flow Metab.
    Ishida et al., 2003, Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease., Nat. Med.
    Vij et al., 2004, Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea., Exp. Eye Res.
    Chaturvedi et al., 2005, Augmentation of Fas ligand-induced apoptosis by MUC1 mucin., Int. J. Oncol.
    Pardo et al., 2003, Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression., Int. Immunol.
    Cullen et al., 2004, Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis., Am. J. Physiol. Gastrointest. Liver Physiol.
    Chen et al., 2002, Luteotropic roles of prolactin in early pregnant hamsters., Biol. Reprod.
    Zhang et al., Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2., Cancer Biol. Ther.
    Song et al., 2003, Vitamin D(3) up-regulating protein 1 (VDUP1) antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of fas ligand and reactive oxygen species., Immunol. Lett.
    Siegmund et al., 2001, Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway., J. Biol. Chem.
  • RIZATRIPTAN   HTR1A

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • RIZATRIPTAN   HTR1E

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • RIZATRIPTAN   HTR1D

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:
    Ikemoto et al., 2004, [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance]., Nippon Yakurigaku Zasshi
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Longmore et al., Comparison of the vasoconstrictor properties of the 5-HT1D-receptor agonists rizatriptan (MK-462) and sumatriptan in human isolated coronary artery: outcome of two independent studies using different experimental protocols., Funct. Neurol.

  • RIZATRIPTAN   HTR1B

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Partial agonist

    Publications:
    Ikemoto et al., 2004, [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance]., Nippon Yakurigaku Zasshi
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Pauwels et al., 1998, Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors: intrinsic activity and modulation by G-protein activation state., Naunyn Schmiedebergs Arch. Pharmacol.

  • RIZATRIPTAN   HTR1F

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:
    Villalón et al., 2002, An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy., Proc. West. Pharmacol. Soc.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Goadsby et al., 2003, Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input., Neuroscience

  • RIZATRIPTAN   FAS

    Interaction Types:
    n/a

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? True

    Publications:
    Villunger et al., 2000, Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes., J. Exp. Med.
    Yu et al., 2003, Synergism of Fas-mediated apoptosis and tumor necrosis factor on adriamycin cytotoxicity to transitional cell carcinoma., Urol. Int.

  • RIZATRIPTAN   BCL2

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Srivastava et al., 1999, Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription., J. Exp. Med.

  • RIZATRIPTAN   CASP3

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Tagami et al., Fas-mediated apoptosis in acute alcoholic hepatitis., Hepatogastroenterology

  • RIZATRIPTAN   CTLA4

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    da Rocha Dias et al., 2001, CTLA-4 blockade of antigen-induced cell death., Blood

  • RIZATRIPTAN   FCGR3A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Wakao et al., 2000, Involvement of granzyme B expression in the enhancement of natural killer activity by beta-endorphin., Brain Behav. Immun.

  • RIZATRIPTAN   FCGR3B

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Wakao et al., 2000, Involvement of granzyme B expression in the enhancement of natural killer activity by beta-endorphin., Brain Behav. Immun.

  • RIZATRIPTAN   FOXO1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Kawano et al., 2002, Decreased akt activity is associated with activation of forkhead transcription factor after transient forebrain ischemia in gerbil hippocampus., J. Cereb. Blood Flow Metab.

  • RIZATRIPTAN   ITGB2

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Ishida et al., 2003, Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease., Nat. Med.

  • RIZATRIPTAN   LUM

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Vij et al., 2004, Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea., Exp. Eye Res.

  • RIZATRIPTAN   MUC1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Chaturvedi et al., 2005, Augmentation of Fas ligand-induced apoptosis by MUC1 mucin., Int. J. Oncol.

  • RIZATRIPTAN   PIK3CG

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Pardo et al., 2003, Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression., Int. Immunol.
    Cullen et al., 2004, Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis., Am. J. Physiol. Gastrointest. Liver Physiol.

  • RIZATRIPTAN   PRL

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Chen et al., 2002, Luteotropic roles of prolactin in early pregnant hamsters., Biol. Reprod.

  • RIZATRIPTAN   TP53

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Zhang et al., Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2., Cancer Biol. Ther.

  • RIZATRIPTAN   TXNIP

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Song et al., 2003, Vitamin D(3) up-regulating protein 1 (VDUP1) antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of fas ligand and reactive oxygen species., Immunol. Lett.

  • RIZATRIPTAN   FADD

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Siegmund et al., 2001, Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway., J. Biol. Chem.

  • DrugBank: DB00953

    • Version: 5.0.8

    Alternate Names:
    RIZATRIPTAN DrugBank Drug Name
    N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine Drug Synonym
    N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine Drug Synonym

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories amines

    Publications:
    Villalón et al., 2002, An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy., Proc. West. Pharmacol. Soc.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Goadsby et al., 2003, Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input., Neuroscience

  • TEND: RIZATRIPTAN

    • Version: 01-August-2011

    Alternate Names:
    RIZATRIPTAN Primary Drug Name

    Drug Info:
    Year of Approval 1998
    Drug Class anti-migraine agents

    Publications:

  • GuideToPharmacologyInteractions: 5078

    • Version: 27-September-2017

    Alternate Names:
    FASLG Gene Symbol (for Endogenous Peptides)
    FAS LIGAND GuideToPharmacology Ligand Name
    178101771 PubChem Drug SID

    Drug Info:
    Name of the Ligand Species (if a Peptide) Human

    Publications:

  • TdgClinicalTrial: RIZATRIPTAN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-migraine Agents
    Drug Class small molecule
    FDA Approval 1998

    Publications:

  • NCI: FAS LIGAND

    • Version: 14-September-2017

    Alternate Names:
    C1538 NCI drug code

    Drug Info:

    Publications:
    Srivastava et al., 1999, Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription., J. Exp. Med.
    Wakao et al., 2000, Involvement of granzyme B expression in the enhancement of natural killer activity by beta-endorphin., Brain Behav. Immun.
    Pardo et al., 2003, Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression., Int. Immunol.

  • NCI: FAS-LIGAND

    • Version: 14-September-2017

    Alternate Names:
    C1538 NCI drug code

    Drug Info:

    Publications:
    Ishida et al., 2003, Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease., Nat. Med.
    da Rocha Dias et al., 2001, CTLA-4 blockade of antigen-induced cell death., Blood
    Chen et al., 2002, Luteotropic roles of prolactin in early pregnant hamsters., Biol. Reprod.

  • TTD: DAP000220

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    I06-2272 Drug Synonym
    CID5078 Drug Synonym
    DAP000220 TTD Drug Id

    Drug Info:

    Publications:

  • PubChem: RIZATRIPTAN

    • Version: 09-Feb-2016

    Alternate Names:
    51086HBW8G Drug Synonym
    RIZATRIPTAN pubchem_primary_name
    5078 PubChem CID

    Drug Info:

    Publications:

  • GuideToPharmacologyInteractions: 51

    • Version: 27-September-2017

    Alternate Names:
    RIZATRIPTAN GuideToPharmacology Ligand Name
    135650905 PubChem Drug SID

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25