• PHENYLBUTAZONE CHEMBL101

    Alternate Names:

    Phenylbutazone
    Butacote
    Diphenylbutazone
    Butazolidin
    Azolid
    Pro-Bute
    Equiphar
    Elmedal
    Butaject
    Antadol
    BUTAGESIC
    BUTADIONA
    FENILIDINA
    PHENYZONE
    ARTRIZONE
    C07440
    PHENBUTAZONE
    INTALBUT
    BUSONE
    4617
    9644
    INTRAZONE
    SHIGRODIN
    NADOZONE
    COTYLBUTAZONE
    ALKABUTAZONA
    TETNOR
    THERAZONE
    BUTARECBON
    REUMAZOL
    D00510
    REUPOLAR
    ALQOVERIN
    ROBIZONE-V
    B.T.Z.
    TENCODYNE
    ESTEVE'
    BIZOLIN 200
    USAF GE-15
    ECOBUTAZONE
    BUTIDIONA
    ERIBUTAZONE
    BUTOZ
    CCCCC1C(=O)N(N(C1=O)C2CCCCC2)C3CCCCC3
    BUTATRON
    MEPHABUTAZONE
    TODALGIL
    PHENYLBUTAZ
    596701
    AZDID
    ROBIZON-V
    PHENYZENE
    BUTARTRINA
    BUZON
    PIRARREUMOL B
    BUTA PHEN
    FENARTIL
    4781
    FENYLBUTAZON
    BIZOLIN
    ARTHRIZON
    MALGESIC
    ANERVAL
    REUMASYL
    FEBUZINA
    WESCOZONE
    DAP000974
    FENILBUTINE
    FENIBUTOL
    MEPHA-BUTAZON
    PIRARREUMOL "B"
    PHEBUZIN
    BUTIWAS-SIMPLE
    ALKA BUTAZOLIDIN
    EXRHEUDON N
    ARTROPAN
    BUTYLPYRIN
    RECTOFASA
    46507038
    BENZONE
    FENOTONE
    REUDOX
    PHENBUTAZOL
    DIOSSIDONE
    ANUSPIRAMIN
    PRAECIRHEUMIN
    BUTACOMPREN
    P1Z
    FENILBUTAZONA
    ANPUZONE
    BUTAPIRAZOLE
    ARTIZIN
    PYRABUTOL
    PYRAZOLIDIN
    VAC-10
    BUTAZINA
    INTRABUTAZONE
    BUVETZONE
    BUTAPYRAZOLE
    ROBIZONE
    DIGIBUTINA
    MERIZONE
    REUMUZOL
    BUTE
    EQUIPALAZONE
    UZONE
    MEPHABUTAZON
    NADAZONE
    PHENYL-MOBUZON
    PHENOPYRINE
    AMBENE
    ALINDOR
    ZOLIDINUM
    EQUI BUTE
    NEO-ZOLINE
    ZOLAPHEN
    BUTAZOLIDINE
    BUNETZONE
    AZOBUTYL
    FENIBUTASAN
    DIOZOL
    PHENYLBUTAZONUM
    BETAZED
    BUTADIONE
    CHEMBUTAZONE
    BUTALIDON
    LINGEL
    DB00812
    SCHEMERGIN
    BUTADION
    BUTAZONE
    BUTALUY
    PHEBUZINE
    FENILBUTINA
    BUTONE
    DIPHEBUZOL
    BUTAPIRAZOL
    REUMUNE
    ARTRIZIN
    FENIBUTAL
    BUTAZONA
    APO-PHENYLBUTAZONE
    RUBATONE
    PA450932
    BUTALGINA
    TAZONE
    FENIBUTAZONA
    IPSOFLAME
    IA-BUT
    BUTARTRIL
    KADOL
    REUMAZIN
    TEVCODYNE
    NOVOPHENYL
    SCANBUTAZONE
    TICINIL
    48574
    REUDO
    Phenylone Plus Tab
    Novo-butazone Tab 100mg
    Apo Phenylbutazone Tab 100mg
    Alka Phenylbutazone Tab
    Alka Phenyl Tab
    50-33-9
    Phenylbutazon
    4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
    4-BUTYL-1,2-diphenyl-pyrazolidine-3,5-dione
    3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine
    178103844
    7270
    NCI-C56531
    PHEN-BUTA-VET
    BUTADIONUM
    1,2-DIPHENYL-3,5-DIOXO-4-BUTYLPYRAZOLIDINE
    NCI-C55414
    KBIOGR_000954
    SPECTRUM_001079
    BRN 0290080
    NINDS_000331
    SR-01000000004-4
    WLN: T5VNNV EHJ BR& CR& E4
    KBIO2_006695
    1,2-DIPHENYL-4-BUTYL-3,5-DIOXOPYRAZOLIDINE
    SPECTRUM1500482
    COMPONENT OF AZOLID-A
    NCGC00023855-03
    3,5-DIOXO-1,2-DIPHENYL-4-N-BUTYL-PYRAZOLIDIN
    1,2-DIPHENYL-4-BUTYL-3,5-PYRAZOLIDINEDIONE
    4-BUTYL-1,2-DIPHENYLPYRAZOLIDINE-3,5-DIONE
    AC1Q2VLE
    CID4781
    R-3-ZON
    AC-683
    CCRIS 2374
    3,5-DIOXE-4 BUTY-1, DIPHENYL-PYRAZOLIDINE
    KBIO2_001559
    P 8386
    PHENYLBUTAZONE (JP15/USP/INN)
    4-BUTYL-1,2 -DIPHENYL-3,5-DIOXO PYRAZOLIDINE
    ART RIZIN
    NCGC00015846-06
    DA-192
    FENILBUTAZONE [DCIT]
    1,2-DIPHENYL-2,3-DIOXO-4-N-BUTYLPYRAZOLINE
    PHENYLBUTAZONUM [INN-LATIN]
    LS-71
    DIVK1C_000331
    NCGC00015846-01
    ESTEVE
    SPECTRUM5_001335
    KBIO3_001589
    PHENYLBUTAZON [GERMAN]
    3,5-DIOXO-4-BUTYL-1-DIPHENYL-PYRAZOLIDINE
    STK388348
    SPBIO_001283
    OPREA1_416494
    1,2-DIPHENYL-3,5-DIOXO-4-N-BUTYLPYRAZOLINE
    FLEXAZONE
    BIO-0693
    MLS001148412
    P1686
    NCGC00023855-06
    FENILBUTAZON
    B.T.Z
    PHENYL BUTAZONE
    HMS501A13
    BUTE, BUTAZOLIDIN, BUTATRON, PHENYLBUTAZONE
    A 7514
    4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE
    KBIO2_004127
    G 13,871
    3,5-PYRAZOLIDINEDIONE, 4-BUTYL-1,2-DIPHENYL-
    AZOLID (TN)
    NCGC00023855-04
    MLS002152929
    4-BUTYL-1,2-DIPHENYL-3,5-DIOXOPYRAZOLIDINE
    HMS2090H17
    KBIOSS_001559
    D010653
    NSC 25134
    MOLPORT-001-783-564
    NSC25134
    NCHEMBIO.128-COMP31
    FENILBUTAZONA [INN-SPANISH]
    NCGC00181112-01
    HSDB 3159
    IDI1_000331
    NCGC00015846-02
    EINECS 200-029-0
    HMS2091P08
    LOPAC-P-8386
    'ESTEVE'
    P8386_SIGMA
    AKOS001592731
    NCGC00023855-07
    G 13871
    UNM000001255503
    FENILBUTAZONE
    SMR000059073
    BUTYL PYRIN
    NCGC00023855-05
    HMS1920H06
    FE NILBUTINE
    NCGC00015846-12
    EU-0100993
    UNII-GN5P7K3T8S
    BUTAPHEN
    SCHEMERGEN
    AC1L1IXW
    EQUIPHEN
    4-BUTYL-1,2-DIPHENYL-3,5-DIOXO PYRAZOLIDINE
    S1654_SELLECK
    DB08343
    LOPAC0_000993
    MLS000069424
    KBIO1_000331
    SPECTRUM2_001282
    SPECTRUM4_000477
    SPECTRUM3_000675
    I01-0883
    4297-92-1
    PHENYLBUTAZONE [USAN:INN:BAN:JAN]
    NCGC00023855-08
    BSPBIO_002369
    CHEBI:48574
    INCHI=1/C19H20N2O2/C1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/H4-13,17H,2-3,14H2,1H
    4-?BUTYL-?1,?2-?DIPHENYL-?3,?5-?PYRAZOLIDINEDIONE
    W-105972
    3B2-0150
    AG-205/04675049
    A828072
    AB00052071-16
    AB00052071-15
    1,2-DIPHENYL-3,5-DIOXO-4-N-BUTYL-PYRAZOLIDINE
    1,2-DIPHENYL-3,5-DIOXO-4-BUTYL-PYRAZOLIDINE
    DR001283
    AN-15603
    NCGC00259358-01
    NCGC00256449-01
    NCGC00015846-15
    NCGC00015846-13
    NCGC00015846-09
    NCGC00015846-08
    NCGC00015846-07
    NCGC00015846-05
    NCGC00015846-04
    NCGC00015846-03
    NSC-757272
    NE30722
    MCULE-4303869118
    LP00993
    KS-5127
    CS-2180
    ZINC100004227
    TOX21_110242_1
    SBB012526
    NSC757272
    NSC-25134
    CCG-39220
    ABP000789
    3,2-DIPHENYL-4-N-BUTYL-PYRAZOLIDIN
    TOX21_302763
    TOX21_201809
    TOX21_110243
    TOX21_110242
    PHENYLBUTAZONE [USP:INN:BAN:JAN]
    3,2-DIPHENYL-4-N-BUTYLPYRAZOLIDINE
    HY-B0230
    ACN-S002468
    COMPONENT OF AZOLID-A (SALT/MIX)
    PHARMAKON1600-01500482
    HMS3649M17
    HMS3369P16
    HMS3263G07
    HMS2233B13
    BCPP000108
    PHENYLBUTAZONE (JP16/USP/INN)
    CTK1G9570
    1,3-DIOXO-4-N-BUTYLPYRAZOLINE
    GTPL7270
    4-BUTYL-1,5-PYRAZOLIDINEDIONE
    4-BUTYL-1,5-DIOXOPYRAZOLIDINE
    3, 4-BUTYL-1,2-DIPHENYL-
    1,5-DIOXO-4-BUTYLPYRAZOLIDINE
    KSC269K7B
    GN5P7K3T8S
    SCHEMBL3632
    EPITOPE ID:124940
    BUTE;BUTAZOLIDIN;BUTATRON
    129-18-0
    4-BUTYL-1,5-DIONE
    1,5-DIOXOPYRAZOLIDINE
    PIRARREUMOL 'B'
    PHEN-BUTA
    PHENYLBUTAZONE/
    ALKAZONE
    BUTAZOLIDINEREG
    4-BUTYL-1,2-DIPHENYL-1,2-DIAZOLIDINE-3,5-DIONE
    CAS-50-33-9
    DSSTOX_GSID_21136
    DSSTOX_RID_75967
    1,2-DIPHENYL-3,5-DIOXO-4-N-BUTYLPYRAZOLIDINE
    DSSTOX_CID_1136
    NCGC00015846-11
    NCGC00015846-10
    VYMDGNCVAMGZFE-UHFFFAOYSA-N
    FT-0689452
    PHENYLBUTAZONE-SUPPLIED BY SELLECK CHEMICALS
    AB2000198
    ST066897
    HE346144
    HE162352

    Drug Info:

    ATC m02aa(antiinflammatory preparations
    ATC m01aa(butylpyrazolidines)
    Drug Type drug/small molecule
    Drug Class anti-inflammatory agents, non-steroidal
    Year of Approval approved before 1982
    Drug Categories topical products for joint and muscular pain
    Drug Categories therapeutic uses
    Drug Categories sensory system agents
    Drug Categories pyrazolones
    Drug Categories pyrazoles
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories peripheral nervous system agents
    Drug Categories musculo-skeletal system
    Drug Categories heterocyclic compounds, 1-ring
    Drug Categories heterocyclic compounds
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2c9 inhibitors
    Drug Categories chemical actions and uses
    Drug Categories central nervous system agents
    Drug Categories azoles
    Drug Categories antirheumatic agents
    Drug Categories antiinflammatory preparations, non-steroids for topical use
    Drug Categories anti-inflammatory agents, non-steroidal
    Drug Categories anti-inflammatory agents
    Drug Categories analgesics, non-narcotic
    Drug Categories analgesics
    Drug Groups vet_approved
    Drug Groups approved
    Drug Type small molecule
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications NSAID
    (4 More Sources)

    Publications:

    Takada et al., 2004, Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation., Oncogene
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Beretta et al., 2005, COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis., Pharmacol. Res.
    Arifah et al., 2002, Pharmacodynamics and pharmacokinetics of phenylbutazone in calves., J. Vet. Pharmacol. Ther.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Reed et al., 1985, Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism., Mol. Pharmacol.
    Marnett et al., 1984, Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom., Mol. Pharmacol.
    Tobin et al., 1986, Phenylbutazone in the horse: a review., J. Vet. Pharmacol. Ther.
    Zitova et al., 2010, Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system., Anal. Biochem.
    Morton et al., 2005, Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis., Res. Vet. Sci.