• PERPHENAZINE CHEMBL567 FDA Approved

    Alternate Names:

    Perphenazine
    Perphenazine Fendizoate
    Perphenazine Maleate
    Etaperazine
    Trilafon
    Trilafon-La
    Fentazin
    Decentan
    Chlorpiprazine
    PIPERAZINEETHANOL, 4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-
    2-{4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]PIPERAZINYL}ETHAN-1-OL
    TRILAFONREG
    FENTAZINREG
    DECENTANREG
    2-{4-[3-(2-CHLORO-PHENOTHIAZIN-10-YL)-PROPYL]-PIPERAZIN-1-YL}-ETHANOL
    2-{4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL}ETHAN-1-OL
    1-(2-HYDROXYETHYL)-4-[3-(2-CHLORO-10-PHENOTHIAZINYL)PROPYL]PIPERAZINE
    .GAMMA.-[4-(.BETA.-HYDROXYETHYL)PIPERAZIN-1-YL]PROPYL-2-CHLOROPHENOTHIAZINE
    2-CHLORO-10-3-[1-(2-HYDROXYETHYL)-4-PIPERAZINYL]PROPYL PHENOTHIAZINE
    WLN: T C666 BN ISJ EG B3- AT6N DNTJ D2Q
    SR-01000000137-4
    I06-1508
    BRD-K10995081-001-05-5
    L000919
    DSSTOX_GSID_23441
    DSSTOX_RID_77031
    P 6402
    D00503
    C07427
    2-(4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINYL)ETHANOL
    1',1-(2-IDROSSIETIL)-4,3-(2-CLORO-10-FENOTIAZIL)PROPILPIPERAZINA [ITALIAN]
    PIPERAZINEETHANOL, 4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-
    DSSTOX_CID_3441
    2-CHLORO-10-[3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPYL]PHENOTHIAZINE
    2-CHLORO-10-(3-(1-(2-HYDROXYETHYL)-4-PIPERAZINYL)PROPYL)PHENOTHIAZINE
    EU-0100930
    EU-0072164
    AB00052390
    1-PIPERAZINEETHANOL, 4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-
    1-PIPERAZINEETHANOL, 4-(3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL)-
    1',1-(2-IDROSSIETIL)-4,3-(2-CLORO-10-FENOTIAZIL)PROPILPIPERAZINA
    LS-112185
    SMR000058180
    SAM002264637
    CPD000058180
    BAS 00139131
    AC-12196
    NCGC00024092-06
    NCGC00024092-05
    NCGC00024092-04
    NCGC00024092-03
    NCGC00015826-10
    NCGC00015826-06
    NCGC00015826-03
    NCGC00015826-01
    IDI1_000880
    DB00850
    AKOS000664046
    STK019818
    SCH-3940
    2-CHLORO-10-3-(1-(2-HYDROXYETHYL)-4-PIPERAZINYL)PROPYL PHENOTHIAZINE
    2-CHLORO-10-(3-(4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL)PHENOTHIAZINE
    1-PIPERAZINEETHANOL, 4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-
    1-PIPERAZINEETHANOL, 4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-
    HMS2093M15
    HMS1922M14
    HMS1568I12
    4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
    RGCVKNLCSQQDEP-UHFFFAOYSA-N
    NINDS_000880
    KBIO3_001596
    KBIO2_007226
    KBIO2_004658
    KBIO2_002090
    KBIO1_000880
    HMS502L22
    STOCK1S-21551
    BPBIO1_000188
    MLS001146929
    MLS000069637
    AI3-50151
    SPECTRUM1503934
    SPBIO_002109
    SPBIO_001603
    PERPHENAZINE [INN:BAN:JAN]
    P6402_SIGMA
    DIVK1C_000880
    BIDD:GT0150
    KBIOSS_002090
    KBIOGR_001445
    GAMMA-(4-(BETA-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL-2-CHLOROPHENOTHIAZINE
    NSC758649
    BSPBIO_002376
    BSPBIO_000170
    2-{4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL}ETHANOL
    1-(2-HYDROXYETHYL)-4-(3-(2-CHLORO-10-PHENOTHIAZINYL)PROPYL)PIPERAZINE
    NCGC00015826-02
    OPREA1_603835
    LOPAC0_000930
    CAS-58-39-9
    2-[4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL]ETHANOL
    4-(3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINEETHANOL
    NSC150866
    LOPAC-P-6402
    EINECS 200-381-5
    SPECTRUM5_001493
    SPECTRUM4_000843
    SPECTRUM3_000758
    SPECTRUM2_001602
    PRESTWICK3_000125
    PRESTWICK2_000125
    PRESTWICK1_000125
    PRESTWICK0_000125
    AC1L1IVB
    PERPHENAZINE [TRILAFON]
    SPECTRUM_001610
    HSDB 3379
    PZC
    4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
    CHEBI:8028
    NSC 150866
    2-(4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)PIPERAZIN-1-YL)ETHANOL
    PRESTWICK_536
    PERPHENAZINUM [INN-LATIN]
    PERFENAZINA [INN-SPANISH]
    C21H26CLN3OS
    APO-PERPHENAZINE
    UNII-FTA7XXY4EZ
    PERFENAZINA [ITALIAN]
    SCH 3940
    PERPHENAZINUM
    TRANQUISAN
    F-MON
    CHLORPERPHENAZINE
    TRIPHENOT
    TRIFARON
    THILATAZIN
    PERFENAZINA
    TRILIFAN
    PERPHENAN
    ETAPERAZIN
    EMESINAL
    ETHAPERAZINE
    2-(4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINYL)ETHANOL #
    2-[4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-PIPERAZIN-1-YL]ETHANOL
    2-[4-[3-(2-CHLORANYLPHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL]ETHANOL
    2-[4-[3-(2-CHLORO-10-PHENOTHIAZINYL)PROPYL]-1-PIPERAZINYL]ETHANOL
    W-105390
    3B2-3270
    A831863
    J10210
    1446-EP2298776A1
    1446-EP2272537A2
    ST24039354
    P1970
    KB-222063
    AB0010670
    ST079662
    SC-89514
    PL060457
    DR002382
    BC204191
    AK115473
    AJ-72574
    NCGC00015826-13
    NCGC00015826-09
    NCGC00015826-08
    NCGC00015826-07
    NCGC00015826-05
    NCGC00015826-04
    NSC-758649
    NSC-150866
    NE42348
    NC00472
    MCULE-6019566915
    LP00930
    KS-5105
    TOX21_110233_1
    ZINC19228902
    SBB037866
    DAP000100
    CCG-39060
    BDBM50130273
    1-PIPERAZINEETHANOL, TRIHYDROCHLORIDE
    TOX21_110233
    PERPHENAZINE [USP:INN:BAN:JAN]
    PHARMAKON1600-01503934
    HMS3370O14
    HMS3262J22
    HMS3259C09
    HMS2232D21
    HMS2095I12
    MOLPORT-001-727-942
    AOB5376
    PERPHENAZINE (JP16/USP/INN)
    PERPHENAZINE (JP15/USP/INN)
    CTK8G2334
    COMPONENT OF TRIAVIL (SALT/MIX)
    MLS002548897
    GTPL209
    SCHEMBL42125
    REGID_FOR_CID_4748
    D010546
    FTA7XXY4EZ
    1-PIPERAZINEETHANOL, 4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-, TRIHYDROCHLORIDE
    NCHEMBIO873-COMP26
    ETRAFON (SALT/MIX)
    CID4748
    .GAMMA.-(4-(.BETA.-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL-2-CHLOROPHENOTHIAZINE
    PERFENAZINE
    58-39-9
    PERPHENAZIN
    4748
    Trilafon Tab 8mg
    Trilafon Tab 4mg
    Trilafon Tab 2mg
    Trilafon Syr 2mg/5ml
    Trilafon Inj 5mg/ml
    Trilafon Conc 16mg/5ml
    Triavil Tab
    Proavil Tab
    Phenazine 8 Tab
    Phenazine 4 Tab
    Phenazine 2 Tab
    Phenazine 16 Tab
    Perphenazine and Amitriptyline Hydrochloride
    Perphenazine Tab 4mg
    Perphenazine Tab 2mg
    Perphenazine 8 Tab 8mg
    Perphenazine 2 Tab 2mg
    Perphenazine 16 Tab
    PMS-levazine 4/25 Tab
    PMS-levazine 3/15 Tab
    PMS-levazine 2/25 Tab
    PMS Perphenazine Tab 8mg
    PMS Perphenazine Tab 4mg
    PMS Perphenazine Tab 2mg
    PMS Perphenazine Tab 16mg
    PMS Perphenazine Concentrate Liq 3.2mg/ml
    Etrafon F Tab
    Etrafon D Tab
    Etrafon A Tab
    Etrafon 2 10
    Elavil Plus Tab
    Apo Peram Tab 3-15
    Apo Peram Tab 2-25
    ETRAFON-A
    PA450882
    C1CCC2C(C1)N(C3CC(CCC3S2)CL)CCCN4CCN(CC4)CCO
    4586
    0781-1046-01
    209
    46507058
    726184
    8028
    148869
    ETRAFON-FORTE
    2-{4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL}ETHANOL DI[(2Z)-BUT-2-ENEDIOATE]
    CHEBI:34912
    25137876
    3534-08-5
    1-PIPERAZINEETHANOL, 4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-, (2Z)-2-BUTENEDIOATE (1:2) (SALT)
    D02037
    C13540
    LS-112191
    7K96LZ09JI
    PERPHENAZINE MALEATE (JP16)
    PERPHENAZINE MALEATE [JAN]
    AC1O60XO
    (Z)-BUT-2-ENEDIOIC ACID; 2-[4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL]ETHANOL
    PERPHENAZINE DIMALEATE
    5352-90-9
    1-PIPERAZINEETHANOL, 4-(3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL)-, MALEATE
    UNII-7K96LZ09JI
    6444477
    135650810

    Drug Info:

    Drug Class antipsychotic agents
    Year of Approval 1957
    Drug Categories tranquilizing agents
    Drug Categories therapeutic uses
    Drug Categories sulfur compounds
    Drug Categories psychotropic drugs
    Drug Categories psycholeptics
    Drug Categories physiological effects of drugs
    Drug Categories phenothiazines with piperazine structure
    Drug Categories phenothiazines
    Drug Categories pharmacologic actions
    Drug Categories organic chemicals
    Drug Categories neurotransmitter agents
    Drug Categories nervous system
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories inorganic chemicals
    Drug Categories heterocyclic compounds, 3-ring
    Drug Categories heterocyclic compounds
    Drug Categories dopamine antagonists
    Drug Categories dopamine agents
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (weak)
    Drug Categories cytochrome p-450 cyp2d6 inhibitors
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2c8 substrates
    Drug Categories cytochrome p-450 cyp2c19 substrates
    Drug Categories cytochrome p-450 cyp2b6 substrates
    Drug Categories cytochrome p-450 cyp1a2 substrates
    Drug Categories cytochrome p-450 cyp1a2 inhibitors (weak)
    Drug Categories cytochrome p-450 cyp1a2 inhibitors
    Drug Categories chemical actions and uses
    Drug Categories central nervous system depressants
    Drug Categories central nervous system agents
    Drug Categories antipsychotic agents (first generation [typical])
    Drug Categories antipsychotic agents
    Drug Groups approved
    Drug Type small molecule
    ATC n05ab(phenothiazines with piperazine structure)
    Drug Type drug/small molecule
    FDA Approval 1957
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    (6 More Sources)

    Publications:

    Qin et al., 1994, Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
    Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
    Talvik et al., 2004, A cross-validation study on the relationship between central D2 receptor occupancy and serum perphenazine concentration., Psychopharmacology (Berl.)
    Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand
    Dolzan et al., 2007, Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment., Am. J. Med. Genet. B Neuropsychiatr. Genet.
    Natochin YuV et al., 1987, Water and sodium transport: effects of calcium channel blocker and calmodulin antagonists on the apical and basolateral membranes of amphibian epithelia., Gen. Physiol. Biophys.
    Mongin et al., 1999, Volume-dependent taurine release from cultured astrocytes requires permissive [Ca(2+)](i) and calmodulin., Am. J. Physiol.
    Kawai et al., 2001, Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature., Curr. Genet.
    Edlind et al., 2002, Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling., Mol. Microbiol.