• MEGESTROL ACETATE CHEMBL1201139 FDA ApprovedAntineoplastic

    Alternate Names:

    Megestrol Acetate
    Megestrol
    Megace
    5071
    Megace Es
    Ovaban
    BDH-1298
    SC-10363
    C1156
    Volidan
    Ovarid
    Nu-megestrol - Tab 40mg
    Nu-megestrol - Tab 160mg
    Niagestin
    Megestrol-40 - Tab 40mg
    Megestrol-160 - Tab 160 mg
    Megestol
    Megestin
    Megestil
    Megestat
    Megeron
    Megace Os
    Maygace
    Magestin
    Linmegestrol - Tab 40mg
    Linmegestrol - Tab 160mg
    Apo-megestrol
    595-33-5
    MGA
    6-Methyl-delta(sup 6)-dehydro-17α-acetoxyprogesterone
    6-Methyl-delta(sup 6)-dehydro-17alpha-acetoxyprogesterone
    6-Methyl-delta(sup 4,6)-pregnadien-17α-ol-3,20-dione acetate
    6-Methyl-delta(sup 4,6)-pregnadien-17alpha-ol-3,20-dione acetate
    6-Methyl-6-dehydro-17α-acetoxyprogesterone
    6-Methyl-6-dehydro-17alpha-acetoxyprogesterone
    6-Methyl-17α-hydroxy-delta(sup 6)-progesterone acetate
    6-Methyl-17α-acetoxypregna-4,6-diene-3,20-dione
    6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate
    6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione
    6-Dehydro-6-methyl-17α-acetoxyprogesterone
    6-Dehydro-6-methyl-17alpha-acetoxyprogesterone
    17α-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
    17α-Acetoxy-6-dehydro-6-methylprogesterone
    17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
    17alpha-Acetoxy-6-dehydro-6-methylprogesterone
    17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate
    17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
    DB00351
    (17-ACETYL-6,10,13-TRIMETHYL-3-OXO-2,8,9,11,12,14,15,16-OCTAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL) ACETATE
    (8ALPHA,14BETA,17ALPHA)-6-METHYL-3,20-DIOXOPREGNA-4,6-DIEN-17-YL ACETATE
    6-METHYL-.DELTA.4,6-PREGNADIEN-17-.ALPHA.-OL-3,20-DIONE ACETATE
    PROGESTERONE, 6-DEHYDRO-17.ALPHA.-HYDROXY-6-METHYL-, ACETATE
    6-METHYL-17.ALPHA.-HYDROXY-.DELTA.6-PROGESTERONE ACETATE
    6-METHYL-17-.ALPHA.-ACETOXYPREGNA-4,6-DIENE-3,20-DIONE
    17.ALPHA.-ACETOXY-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE
    17.ALPHA.-ACETOXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE
    6-METHYL-3,20-DIOXOPREGNA-4,6-DIEN-17-YL ACETATE #
    I06-0031
    LT00244865
    MCULE-7583895634
    AR-1H2191
    COMPONENT OF CO-ERVONUM (SALT/MIX)
    COMPONENT OF KOMBIQUENS (SALT/MIX)
    COMPONENT OF DELPREGNIN (SALT/MIX)
    RQZAXGRLVPAYTJ-UHFFFAOYSA-N
    MOLPORT-005-971-778
    COMPONENT OF WERADYS (SALT/MIX)
    COMPONENT OF VOLIDAN (SALT/MIX)
    COMPONENT OF NUVACON (SALT/MIX)
    SCHEMBL5021332
    COMPONENT OF NOVAL (SALT/MIX)
    AC1Q6OH3
    AC1L1HAP
    6-METHYL-6-DEHYDRO-17.ALPHA.-ACETOXYPROGESTERONE
    6-DEHYDRO-6-METHYL-17.ALPHA.-ACETOXYPROGESTERONE
    17.ALPHA.-ACETOXY-6-DEHYDRO-6-METHYLPROGESTERONE
    6-METHYL-6-DEHYDRO-17.ALPHA.-ACETYLPROGESTERONE
    17ALPHA-ACETOXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE
    6-METHYL-3,20-DIOXOPREGNA-4,6-DIEN-17-YL ACETATE
    4048
    PREGNA-4,6-DIENE-3,20-DIONE, 17-(ACETYLOXY)-6-METHYL-
    D08167
    19090
    PREGNA-4,6-DIENE-3,20-DIONE, 17-HYDROXY-6-METHYL-
    3562-63-8
    EINECS 222-628-6
    MEGESTROLO
    AC1L2DG3
    D008535
    C07120
    9331
    CHRONOPIL (TN)
    CID19090
    LS-118488
    MEGESTROLO [DCIT]
    (8R,9S,10R,13S,14S,17R)-17-ACETYL-17-HYDROXY-6,10,13-TRIMETHYL-2,8,9,11,12,14,15,16-OCTAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-ONE
    HSDB 3233
    MEGESTROL [INN:BAN]
    DAP000861
    17-HYDROXY-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE
    MEGESTROL (INN)
    UNII-EA6LD1M70M
    CHRONOPIL
    MEGESTROLUM [INN-LATIN]
    14-ACETYL-2,8,15-TRIMETHYL-13-METHYLIDENE-5-OXOTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-6,8-DIEN-14-YL ACETATE
    (17-ACETYL-6,10,13-TRIMETHYL-16-METHYLIDENE-3-OXO-1,2,8,9,11,12,14,15-OCTAHYDROCYCLOPENTA[A]PHENANTHREN-17-YL) ACETATE
    17-HYDROXY-6-METHYL-16-METHYLENEPREGNA-4,6-DIENE-3, 20-DIONE ACETATE
    PROGESTERONE, 6-DEHYDRO-17-HYDROXY-6-METHYL-16-METHYLENE-, ACETATE
    6-METHYL-16-METHYLIDENE-3,20-DIOXOPREGNA-4,6-DIEN-17-YL ACETATE
    6-METHYL-16-METHYLENE-3,20-DIOXOPREGNA-4,6-DIEN-17-YL ACETATE
    I06-0860
    LS-118493
    VA11251
    AN-6691
    MELENGESTROL ACETATE [USAN]
    NCIOPEN2_008323
    AC1L2B6N
    6-DEHYDRO-16-METHYLENE-6-METHYL-17-ACETOXYPROGESTERONE
    EINECS 220-859-7
    C25H32O4
    CCRIS 7800
    MGA 100 (STEROID)
    (17-ACETYL-6,10,13-TRIMETHYL-16-METHYLENE-3-OXO-1,2,8,9,11,12,14,15-OCTAHYDROCYCLOPENTA[A]PHENANTHREN-17-YL) ACETATE
    PREGNA-4,6-DIENE-3,20-DIONE, 17-HYDROXY-6-METHYL-16-METHYLENE-, ACETATE
    17-(ACETYLOXY)-6-METHYL-16-METHYLENEPREGNA-4,6-DIENE-3,20-DIONE
    MALENGESTROL ACETATE
    BDH 1921
    MGA 500
    MGA 100
    18020
    2919-66-6
    U-21240
    178101764
    TL1A
    TNFSF15
    LS-118489
    (8R,9S,10R,13S,14S,17R)-17-ACETYL-6,10,13-TRIMETHYL-3-OXO-2,3,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL ACETATE
    (1S,2R,10R,11S,14R,15S)-14-ACETYL-2,8,15-TRIMETHYL-5-OXOTETRACYCLO[8.7.0.0(2),?.0(1)(1),(1)?]HEPTADECA-6,8-DIEN-14-YL ACETATE
    6-METHYL-17.ALPHA.-HYDROXY-.DELTA.(SUP 6)-PROGESTERONE ACETATE
    WLN: L E5 B666 OV KU MUTJ A1 E1 FV1 FOV1 L1
    17-(ACETYLOXY)-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE
    BRD-K19507340-001-03-1
    Q-201346
    PREGNA-4,20-DIONE, 17-HYDROXY-6-METHYL-, ACETATE
    PREGNA-4,20-DIONE, 17-(ACETYLOXY)-6-METHYL-
    AB00383046-15
    AB00383046-14
    AB00383046-13
    14365-EP2316836A1
    14365-EP2311464A1
    MEGESTROL ACETATE-SUPPLIED BY SELLECK CHEMICALS
    D00952
    C08151
    17.ALPHA.-ACETOXY-6-METHYLPREGNA-4,20-DIONE
    17-HYDROXY-6-METHYLPREGNA-4,20-DIONE ACETATE
    FT-0653983
    AB00490013
    TR-031797
    AB2000040
    17.ALPHA.-ACETOXY-6-METHYL-4,20-DIONE
    SC-16134
    PL057943
    I040
    HY-13676
    BDH-1298, NSC-71423
    AN-21566
    AK145584
    AJ-47998
    AC-14418
    NCGC00255456-01
    NCGC00024196-05
    NCGC00024196-03
    17-ACETOXY-6-METHYLPREGNA-4,20-DIONE
    NC00149
    CS-2065
    CCG-100899
    BCP9000904
    TOX21_110469_1
    AKOS015894927
    ZINC04097467
    LMST02030118
    ANW-43468
    TOX21_302360
    TOX21_110469
    ZINC4097467
    NSC71423
    HMS2235D16
    HMS2097P14
    HMS2090N04
    HMS2051I20
    HMS1570P14
    BCPP000168
    RQZAXGRLVPAYTJ-GQFGMJRRSA-N
    MOLPORT-005-934-820
    CTK5B0088
    46420_FLUKA
    MEGESTROL ACETATE [USAN:USP]
    BPBIO1_001048
    46420_RIEDEL
    17ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE 17-ACETATE
    SPBIO_003101
    M0513_SIGMA
    M0513_FLUKA
    MLS001424055
    MLS001074091
    MLS000759501
    MLS000028633
    BSPBIO_000952
    AMBAP595-33-5
    AC1L1XW9
    TJ2M0FR8ES
    SCHEMBL745
    PRESTWICK3_000956
    PRESTWICK2_000956
    PRESTWICK1_000956
    PRESTWICK0_000956
    S1304_SELLECK
    MEGESTROL (ACETATE)
    MEGACE (TN)
    CAS-595-33-5
    51154-23-5
    NCGC00016516-01
    MEGACE;MEGACE ES
    MEGESTROL ACETOLE
    MEGESTROLACETATE
    17ALPHA-HYDROXY-6-METHYL-6-DEHYDROPROGESTERONE 17-ACETATE
    SMR000058691
    [(8R,9S,10R,13S,14S,17R)-17-ACETYL-6,10,13-TRIMETHYL-3-OXO-2,8,9,11,12,14,15,16-OCTAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL] ACETATE
    MEGESTROL 17-ACETATE
    MEGACE, MEGACE ES, MEGESTROL ACETATE
    6-METHYL-DELTA(SUP 4,6)-PREGNADIEN-17-ALPHA-OL-3,20-DIONE ACETATE
    PREGNA-4,6-DIENE-3,20-DIONE, 17-HYDROXY-6-METHYL-, ACETATE
    6-METHYL-DELTA4,6-PREGNADIEN-17ALPHA-OL-3,20-DIONE ACETATE
    6-METHYL-17-ALPHA-HYDROXY-DELTA(SUP 6)-PROGESTERONE ACETATE
    6-METHYL-DELTA(SUP 6)-DEHYDRO-17-ALPHA-ACETOXYPROGESTERONE
    17-HYDROXY-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE ACETATE
    6-METHYL-17-ALPHA-ACETOXYPREGNA-4,6-DIENE-3,20-DIONE
    17ALPHA-ACETOXY-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE
    DSSTOX_GSID_40683
    DSSTOX_RID_79539
    DSSTOX_CID_20683
    6-METHYL-6-DEHYDRO-17-ALPHA-ACETOXYPROGESTERONE
    6-DEHYDRO-6-METHYL-17-ALPHA-ACETOXYPROGESTERONE
    17-ALPHA-ACETOXY-6-DEHYDRO-6-METHYLPROGESTERONE
    MEGESTROL ACETATE [USAN]
    MEGESTROL ACETATE (USAN)
    SC10363
    EINECS 209-864-5
    MEGESTROL ACETOLE [PROGESTINS]
    CCRIS 372
    SC 10363
    NSC-71423
    UNII-TJ2M0FR8ES
    BDH 1298
    OVABAN (VETERINARY)
    PALLACE
    MEGESTRYL ACETATE
    11683
    [(8R,9S,10R,13S,14S,17R)-17-ACETYL-10,13-DIMETHYL-3-OXO-2,8,9,11,12,14,15,16-OCTAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL] ACETATE
    (8R,9S,10R,13S,14S,17R)-17-ACETYL-10,13-DIMETHYL-3-OXO-2,3,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL ACETATE
    (1S,2R,10R,11S,14R,15S)-14-ACETYL-2,15-DIMETHYL-5-OXOTETRACYCLO[8.7.0.0(2),?.0(1)(1),(1)?]HEPTADECA-6,8-DIEN-14-YL ACETATE
    29522-EP2311842A2
    29522-EP2311825A1
    29522-EP2311453A1
    29522-EP2305642A2
    29522-EP2298768A1
    29522-EP2298765A1
    29522-EP2298764A1
    29522-EP2298748A2
    29522-EP2295427A1
    29522-EP2295426A1
    29522-EP2295416A2
    29522-EP2295055A2
    29522-EP2280012A2
    29522-EP2275420A1
    29522-EP2272825A2
    29522-EP2269989A1
    17-HYDROXYPREGNA-4,6-DIENE-3,20-DIONE=ACETATE
    FT-0665585
    LS-118486
    PL019899
    MCULE-8861434212
    AKOS015955642
    ZINC03881640
    NSC-77897
    ZINC3881640
    NSC77897
    BB_NC-0635
    MOLPORT-002-507-159
    CHEBI:6723
    SCHEMBL149089
    AC1L43PS
    425-51-4
    PREGNA-4,6-DIENE-3,20-DIONE, 17-HYDROXY-, ACETATE (ESTER)
    17-HYDROXYPREGNA-4,6-DIENE-3,20-DIONE ACETATE (ESTER)
    17-HYDROXYPREGNA-4,6-DIENE-3,20-DIONE ACETATE
    DELTA(SUP 6)-DEHYDRO-17-ACETOXYPROGESTERONE
    NSC 77897
    200136
    MELENGESTRO ACETATE
    (1S,2R,10R,11S,14R,15S)-14-ACETYL-14-HYDROXY-2,8,15-TRIMETHYLTETRACYCLO[8.7.0.0?,?.0??,??]HEPTADECA-6,8-DIEN-5-ONE
    (1S,2R,10R,11S,14R,15S)-14-ACETYL-14-HYDROXY-2,8,15-TRIMETHYLTETRACYCLO[8.7.0.0(2),?.0(1)(1),(1)?]HEPTADECA-6,8-DIEN-5-ONE
    3B3-070736
    PREGNA-4,6-DIENE-3,20-DIONE,17-HYDROXY-6-METHYL-
    7-HYDROXY-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE
    ST24047525
    PL002488
    I037
    LMST02030177
    CM0090
    ABP000337
    ZINC4097356
    EA6LD1M70M
    SCHEMBL8942
    318164850
    ETRASIMOD

    Drug Info:

    Drug Categories therapeutic uses
    Drug Categories steroids
    Drug Categories sex hormones and modulators of the genital system
    Drug Categories reproductive control agents
    Drug Categories progestogens and estrogens, sequential preparations
    Drug Categories pregnanes
    Drug Categories pregnadienes
    Drug Categories polycyclic compounds
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories p-glycoprotein/abcb1 inhibitors
    Drug Categories megestrol
    Drug Categories hyperglycemia-associated agents
    Drug Categories genito urinary system and sex hormones
    Drug Categories contraceptives, oral, synthetic
    Drug Categories contraceptives, oral
    Drug Categories contraceptive agents, female
    Drug Categories contraceptive agents
    Drug Categories chemical actions and uses
    Drug Categories central nervous system stimulants
    Drug Categories central nervous system agents
    Drug Categories appetite stimulants
    Drug Categories antineoplastic agents, hormonal
    Drug Categories antineoplastic agents
    Drug Groups vet_approved
    Drug Groups approved
    Drug Type small molecule
    Name of the Ligand Species (if a Peptide) Human
    Year of Approval 1971
    Drug Class antineoplastic agents, hormonal
    Drug Class contraceptives
    FDA Approval 1971
    Drug Class small molecule
    Drug Indications Contraceptives
    Drug Indications Antineoplastic Agents, Hormonal
    (10 More Sources)

    Publications:

    Mokbel, 2003, Focus on anastrozole and breast cancer., Curr Med Res Opin
    Gruber et al., 2004, Multiple meningiomas arising during long-term therapy with the progesterone agonist megestrol acetate. Case report., J. Neurosurg.
    Wentling et al., Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature., Int. J. Gynecol. Cancer
    Wiedemann et al., 1998, Sleep endocrine effects of megestrol acetate in healthy men., J. Neuroendocrinol.
    Lamberts et al., 1985, Comparison of the actions of RU 38486 and megestrol acetate in the model of a transplantable adrenocorticotropin- and prolactin-secreting rat pituitary tumor., Cancer Res.
    Schindler et al., Classification and pharmacology of progestins., Maturitas
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Vadivelu et al., 2010, Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy., J. Neurosurg.
    Wermers et al., 2004, Osteoporosis associated with megestrol acetate., Mayo Clin. Proc.
    Kontula et al., 1983, Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes., Biochem. Pharmacol.
    Chao et al., 1997, Phase II study of megestrol acetate in the treatment of hepatocellular carcinoma., J. Gastroenterol. Hepatol.
    González Villarroel et al., 2008, Megestrol acetate-induced adrenal insufficiency., Clin Transl Oncol
    Tansan et al., 1997, Augmentation of vincristine cytotoxicity by megestrol acetate., Cancer Chemother. Pharmacol.
    Lambert et al., 2004, Effects of megestrol acetate on circulating interleukin-15 and interleukin-18 concentrations in healthy elderly men., J. Gerontol. A Biol. Sci. Med. Sci.
    Mantovani et al., 1995, Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy., Int. J. Clin. Lab. Res.
    Vollmer et al., 1998, The dynamics of prostate specific antigen in hormone refractory prostate carcinoma: an analysis of cancer and leukemia group B study 9181 of megestrol acetate., Cancer