• LORATADINE CHEMBL998 FDA Approved

    Alternate Names:

    Clarityne
    Loratadine
    Roletra
    Hay-Rite
    Clarityn
    Clarityn Rapide
    Claritin
    Alavert
    Claritin-D
    SCH-29851
    Loratadine Redidose
    Claritin Reditabs
    Claritin Hives Relief Reditab
    Claritin Hives Relief
    Children's Claritin
    C29162
    Loratadine D
    Loratadine Antihistamine
    Loratadine Allergy Relief
    Lorastine
    Loranox
    Loradex
    Loracert
    Lomilan
    Live Better Loratadine
    Liberator
    Leader Loratadine
    Leader Childrens Allergy Relief
    Leader Allergy Relief D-24
    Leader Allergy Relief
    Kirkland Signature Allerclear D 24hr
    Kirkland Signature Allerclear D 12 Hr
    Kirkland Signature Allerclear
    Hy-vee Childrens Loratadine
    Humana Pharmacy Allergy Relief
    Histaloran
    Help I Have Allergies
    Healthy Accents Allergy and Congestion Relief 24 Hour Non Drowsy
    Healthy Accents Allergy Relief
    Healthmart Loratadine ODT
    Healthmart Childrens Loratadine
    Health Mart Pharmacy Childrens Loratadine
    Health Mart Loratadine
    Health Mart Allergy and Congestion
    Health Mart Allergy Relief
    Harris Teeter Allergy and Congestion Relief
    Harris Teeter Allergy Relief
    Harmon Face Values Allergy Relief
    Handy Solutions 24 Hour Allergy
    Good Sense Childrens Loratadine
    Good Sense Allergy and Congestion Relief Non Drowsy 24 Hour
    Good Sense Allergy and Congestion Relief
    Good Sense Allergy Relief
    Good Neighbor Pharmacy Loratadine D 24 Hour
    Good Neighbor Pharmacy Loratadine D
    Good Neighbor Pharmacy Loratadine
    Good Neighbor Pharmacy Cleartime
    Good Neighbor Pharmacy Childrens Loratadine
    Good Neighbor Pharmacy Allergy Relief
    Fristamin
    Formucare Allergy Relief
    Family Wellness Allergy Relief
    Family Dollar Allergy Relief
    Fad First Aid Direct Allergy Relief
    Exchange Select Allergy Relief
    Equate Childrens Allergy Relief
    Equate Allergy Relief
    Equaline Childrens Loratadine
    Equaline Allergy and Congestion Relief
    Equaline Allergy Relief Non Drowsy
    Equaline Allergy Relief
    Dg Health Allergy Relief
    Counteract Allergy
    Claritin-D 24 Hour
    Claritin-D 12 Hour
    Claritin Syrup 1mg/ml
    Claritin Rapid Dissolve
    Claritin Liquid Capsules
    Claritin Liqui-gels
    Claritin Kids
    Claritin Antihistamine
    Claritin Allergy + Sinus Extra Strength
    Claritin Allergy + Sinus
    Civeran
    Chlor-tripolon Nd Srt
    Childrens Wal-itin
    Childrens Non-drowsy Allergy Relief 24-hour
    Childrens Non-drowsy 24-hour Allergy Relief
    Childrens Loratadine Sugar Free
    Childrens Loratadine
    Childrens Allergy Relief
    Childrens Allergy Dye Free
    Childrens Allergy
    Childrens 24 Hour Allergy
    Children Claritin Allergy
    Careone Allergy and Congestion Relief
    Careone Allergy Relief 24 Hour
    Care One Childrens Loratadine
    Biloina
    Best Choice Childrens Loratadine Sugar Free
    Best Choice Childrens Loratadine
    Berkley and Jensen Loratadine Non Drowsy
    Berkley and Jensen Allergy Relief
    Being Well Allergy Relief
    Bactimicina Allergy
    Apo-loratadine
    Allertin Tablets 10mg
    Allertin
    Allergy and Congestion Relief Non Drowsy
    Allergy and Congestion Relief
    Allergy Remedy
    Allergy Relief-d24 Hour 24 Hour
    Allergy Relief Non Drowsy
    Allergy Relief Medication
    Allergy Relief D 12 Hour
    Allergy Relief D 12
    Allergy Relief Childrens
    Allergy Relief 24 Hour
    Allergy
    Allerclear-D 24 Hour
    Allegy Relief 24 Hour Non Drowsy
    Alavert Allergy Sinus D-12
    Alavert Allergy
    Loratadine OD
    Western Family Childrens Allergy Relief
    Welby Health Allergy Relief
    Wal-itin D 24 Hour
    Wal-itin Allergy Relief
    Wal-itin
    Wal Itin D Non Drowsy 24 Hour Allergy and Congestion
    Wal Itin D Non Drowsy
    Wal Itin D 12 Hour Allergy and Congestion
    Wal Itin D
    Wal Itin
    Vicks Qlearquil All Day and All Night 24 Hour Allergy Relief
    Up and Up Allergy and Congestion Relief
    Up and Up Allergy Relief
    Up and Up Allergy Plus Congestion Relief D
    Topcare Clear Time
    Topcare Childrens Loratadine
    Topcare Childrens Allergy Relief 24 Hour Non Drowsy
    Topcare Allergy Relief D
    Topcare Allergy Relief 24 Hour
    Topcare Allergy Relief
    Taro-loratadine
    Sunmark Loratadine ODT
    Sunmark Loratadine D
    Sunmark Loratadine Allergy Relief
    Sunmark Loratadine
    Sunmark Childrens Loratadine
    Sunmark Allergy Relief
    Sound Body Allergy Relief
    Smart Sense Allergy and Congestion Relief Indoor and Outdoor Allergies
    Smart Sense Allergy and Congestion Relief
    Smart Sense Allergy Relief Non Drowsy
    Simply Right Loratadine
    Signature Care Allergy and Congestion Relief
    Signature Care Allergy Relief
    Shoprite Allergy and Congestion Relief
    Shoprite Allergy Relief
    Sensibit
    Rexall Allergy Relief Non Drowsy
    Restamine
    Quality Choice Childrens Allergy Relief
    Premier Value Childrens Loratadine
    Preferred Plus Allergy and Congestion Relief
    Preferred Plus Allergy Relief
    Preferred Plus (kinray) Childrens Loratadine
    Nularef
    Novo-loratadine
    Moore Medical Loratadine
    Members Mark Loratadine
    Meijer Childrens 24 Hour Allergy
    Medique Loradamed
    Medicine Shoppe Loratadine Allergy Relief
    Medicine Shoppe Allergy Relief D24
    Loritine
    Loratyne
    Loratadineantihistamine Antihistamine
    Loratadine and Pseudoephedrine Sulfate
    Loratadine and Pseudoephedrine
    Loratadine Tablets 10mg
    Loratadine Soft Gel Capsule
    Loratadine ODT
    Loratadine D 24 Hour
    Aerotina
    7 Select Allergy Relief
    24 Hour Allergy Remedy
    24 Hour Allergy Relief
    79794-75-5
    DB00455
    1-PIPERIDINECARBOXYLIC ACID,4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDIN-11-YLIDENE)-,ETHYL ESTER
    I14-0747
    BRD-K82795137-001-10-6
    BRD-K82795137-001-02-3
    4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
    1-PIPERIDINECARBOXYLIC ACID, 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-, ETHYL ESTER
    L000667
    DSSTOX_GSID_23224
    DSSTOX_RID_76931
    L 9664
    D00364
    DSSTOX_CID_3224
    L0223
    EU-0100680
    TL8005389
    LS-114660
    SMR000058255
    SAM001246987
    NCI60_041473
    CPD000058255
    NCGC00023125-07
    NCGC00023125-06
    NCGC00023125-05
    NCGC00023125-04
    NCGC00023125-02
    NCGC00015619-10
    NCGC00015619-09
    NCGC00015619-06
    NCGC00015619-02
    NCGC00015619-01
    IDI1_000792
    AC-2086
    1-PIPERIDINECARBOXYLIC ACID, 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDIN-11-YLIDENE)-, ETHYL ESTER
    ZINC00537931
    STK574925
    NSC721075
    LORATADINE-D4
    HMS2093I15
    HMS2090O18
    HMS2051G11
    BB_SC-2109
    JCCNYMKQOSZNPW-UHFFFAOYSA-N
    NINDS_000792
    KBIO3_001520
    KBIO2_007112
    KBIO2_004544
    KBIO2_001976
    KBIO1_000792
    HMS502H14
    ETHYL 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLATE
    MLS001148466
    MLS000758260
    MLS000069647
    SPECTRUM1503712
    SPBIO_001548
    LORATADINE [USAN:BAN:INN]
    LORATADINE (JAN/USAN/INN)
    L9664_SIGMA
    DIVK1C_000792
    BIDD:GT0198
    ALAVERT, CLARITIN, LORATADINE
    KBIOSS_001976
    KBIOGR_000693
    BSPBIO_002300
    OPREA1_027965
    LOPAC0_000680
    AC1L1H3E
    ETHYL 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)PIPERIDINE-1-CARBOXYLATE
    LOPAC-L-9664
    SPECTRUM5_001650
    SPECTRUM4_000177
    SPECTRUM3_000740
    SPECTRUM2_001584
    TOCRIS-1944
    SPECTRUM_001496
    HSDB 3578
    S1358_SELLECK
    SCH29851
    C22H23CLN2O2
    CLARITIN (TN)
    UNII-7AJO3BO7QN
    CLARITYNE DY REPETABS
    CLARATYNE DECONGESTANT
    CLARITIN D
    CLARITYNE-D
    CLARITIN REDITAB
    CLARATYNE COLD
    LORATADINA [SPANISH]
    LORATADINA
    CLARIUM
    LORATADINUM [LATIN]
    LORATADINUM
    SCH 29851
    CLARINASE REPERABS
    TALORAT DY
    BEDIX LORATADINA
    SINHISTAN DY
    ZEOS
    PYLOR
    LERGY
    VELODAN
    TADINE
    SOHOTIN
    SANELOR
    RINOMEX
    RHINASE
    OPTIMIN
    LORFAST
    LORAVER
    LORADIF
    LESIDAS
    ALARIN
    POLARATYNE
    LOWADINA
    LORANTIS
    CLARINASE
    CLARATYNE
    ANHISSEN
    ALLERTIDIN
    ALERPRIV
    VERSAL
    LERTAMINE
    CLARITINE
    BONALERG
    ETHYL 4-{13-CHLORO-4-AZATRICYCLO[9.4.0.0^{3,8}]PENTADECA-1(11),3(8),4,6,12,14-HEXAEN-2-YLIDENE}PIPERIDINE-1-CARBOXYLATE
    ETHYL 4-{13-CHLORO-4-AZATRICYCLO[9.4.0.0?,?]PENTADECA-1(11),3(8),4,6,12,14-HEXAEN-2-YLIDENE}PIPERIDINE-1-CARBOXYLATE
    ETHYL 4-{13-CHLORO-4-AZATRICYCLO[9.4.0.0(3),?]PENTADECA-1(15),3,5,7,11,13-HEXAEN-2-YLIDENE}PIPERIDINE-1-CARBOXYLATE
    ETHYL 4-(8-CHLORO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11(6H)-YLIDENE)PIPERIDINE-1-CARBOXYLATE
    ETHYL 4-(8-CHLORO-5,6-DIHYDROBENZO[1,2]CYCLOHEPTA[2,4-B]PYRIDIN-11-YLIDENE)PIPERIDINE-1-CARBOXYLATE
    ETHYL 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDINE)-1-PIPERIDINECARBOXYLATE
    ETHYL 4-(13-CHLORO-4-AZATRICYCLO[9.4.0.0(3,8)]PENTADECA-1(11),3(8),4,6,12,14-HEXAEN-2-YLIDENE)PIPERIDINE-1-CARBOXYLATE
    8-CHLORO-6,11-DIHYDRO-11-(1-ETHOXYCARBONYL-4-PIPERIDYLIDENE)-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
    8-CHLORO-6,11-DIHYDRO-11-(1- ETHOXYCARBONYL-4-PIPERIDYLIDENE)-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
    8-CHLORO-11-(1-ETHOXYCARBONYL-4-PIPERIDYLIDENE)-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
    4-(8-CHLORO-5,6-DIHYDROBENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)PIPERIDINE-1-CARBOXYLIC ACID ETHYL ESTER
    4-(8-CHLORO-5,6-DIHYDRO-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-PIPERIDINE-1-CARBOXYLIC ACID ETHYL ESTER
    4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLATE
    11-[N-(ETHOXYCARBONYL)-4-PIPERIDYLIDENE]-8-CHLORO-6,11-DIHYDRO-5H-BENZO-[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
    1-PIPERIDENECARBOXYLIC ACID,6-DUHYDRO-11H-BENZO [5,6]CYCLOHEPTA[1,2-B]-PYRIDIN-11-YLIDENE)-, ETHYL ESTER
    1-PIPERIDENECARBOXYLIC ACID, 4-(8-CHLORO-5,6-DUHYDRO-11H-BENZO [5,6]CYCLOHEPTA[1,2-B]-PYRIDIN-11-YLIDENE)-, ETHYL ESTER
    Q-100833
    3B2-0771
    AB00053224-16
    AB00053224-15
    M-5196
    J10034
    FT-0627976
    ST2413201
    AB2000066
    AB0012486
    BCP0726000007
    ZB014352
    PL070147
    HY-17043
    DR002174
    AN-14336
    AK-88666
    AJ-23376
    NCGC00255171-01
    NCGC00015619-13
    NCGC00015619-12
    NCGC00015619-11
    NCGC00015619-08
    NCGC00015619-07
    NCGC00015619-05
    NCGC00015619-04
    NCGC00015619-03
    LORATADINE-SUPPLIED BY SELLECK CHEMICALS
    NSC-758628
    NSC-721075
    NC00036
    MCULE-5073177964
    LP00680
    KS-1079
    CS15960
    CS-0887
    CCG-100786
    BCP9000858
    AB06849
    TOX21_110185_1
    AKOS005499513
    NSC758628
    MFCD00672869
    HTS028367
    FC1275
    DL-436
    DAP000101
    CL0028
    CCG-39362
    BBL010757
    TOX21_301532
    TOX21_110185
    ACT04775
    ACN-S002091
    LORATADINE [USAN:USP:INN:BAN]
    ZINC537931
    PHARMAKON1600-01503712
    HMS3393G11
    HMS3371D13
    HMS3268M16
    HMS3262G21
    HMS2235G23
    MOLPORT-002-507-846
    HMDB05000
    CTK8G0633
    BDBM22876
    TOPCARE CHILDRENS ALLERGY RELIEF
    GTPL7216
    MLS001423984
    REGID_FOR_CID_3957
    D017336
    SCHEMBL4596
    7AJO3BO7QN
    CID3957
    ALAVERT;CLARITIN
    KLARITIN
    FLONIDAN
    CRONOPEN
    CLARITINREG
    WYETH BRAND OF LORATADINE
    LORATADINE WYETH BRAND
    CAS-79794-75-5
    ETHYL 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLATE
    4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTAL[1,2-B]PYRIDIN-11-YLIDENE-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
    4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
    4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
    LISINO
    LORATIDINE
    3957
    192028
    178100784
    [11C]PYRILAMINE
    2244692
    46507853
    3820
    PA450266
    22876
    CCOC(=O)N1CCC(=C2C3CCC(CC3CCC4C2NCCC4)CL)CC1
    0378-1925-01
    178103791
    7216

    Drug Info:

    Drug Categories therapeutic uses
    Drug Categories respiratory system
    Drug Categories polycyclic hydrocarbons, aromatic
    Drug Categories polycyclic compounds
    Drug Categories piperidines
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories p-glycoprotein/abcb1 inhibitors
    Drug Categories organic chemicals
    Drug Categories neurotransmitter agents
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories hydrocarbons, cyclic
    Drug Categories hydrocarbons, aromatic
    Drug Categories hydrocarbons
    Drug Categories histamine h1 antagonists, non-sedating
    Drug Categories histamine h1 antagonists
    Drug Categories histamine antagonists
    Drug Categories histamine agents
    Drug Categories heterocyclic compounds, 1-ring
    Drug Categories heterocyclic compounds
    Drug Categories dibenzocycloheptenes
    Drug Categories dermatologic agents
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a inhibitors
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (weak)
    Drug Categories cytochrome p-450 cyp2d6 inhibitors
    Drug Categories cytochrome p-450 cyp2d6 inducers
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2c9 inhibitors
    Drug Categories cytochrome p-450 cyp2c8 substrates
    Drug Categories cytochrome p-450 cyp2c8 inhibitors
    Drug Categories cytochrome p-450 cyp2c19 inhibitors
    Drug Categories cytochrome p-450 cyp2c19 inducers
    Drug Categories cyproheptadine
    Drug Categories combined inhibitors of cyp3a4 and p-glycoprotein
    Drug Categories chemical actions and uses
    Drug Categories central nervous system depressants
    Drug Categories benzocycloheptenes
    Drug Categories antipruritics
    Drug Categories antihistamines for systemic use
    Drug Categories anti-allergic agents
    Drug Groups approved
    Drug Type small molecule
    Year of Approval 1993
    Drug Class anti-allergic agents
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiasthmatic agent
    ATC r06ax(other antihistamines for systemic use)
    Drug Type drug/small molecule
    ATC c09aa(ace inhibitors
    (5 More Sources)

    Publications:

    Cavero et al., 1999, Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?, Drug Saf
    Grzelewska-Rzymowska et al., 1992, [Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction]., Pneumonol Alergol Pol
    Howarth, 1990, Histamine and asthma: an appraisal based on specific H1-receptor antagonism., Clin. Exp. Allergy
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Letari et al., 1994, Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity., Eur. J. Pharmacol.
    Menardo et al., A review of loratadine in the treatment of patients with allergic bronchial asthma., Clin Ther
    Cieślewicz et al., 1992, [Effect of loratadine--selective antagonist of histamine (H1) receptor--on allergen-induced bronchoconstriction in atopic asthmatics]., Pneumonol Alergol Pol
    Cieślewicz et al., 1995, [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction]., Pneumonol Alergol Pol
    Baroody et al., 2000, Antiallergic effects of H1-receptor antagonists., Allergy
    Tamura et al., 2005, Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice., Pharmacology
    Traidl-Hoffmann et al., 2006, Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines., Int. Arch. Allergy Immunol.
    Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.
    Van Neste et al., 1992, Agonist-antagonist interactions in the skin: comparison of effects of loratadine and cetirizine on skin vascular responses to prick tests with histamine and substance P., J. Dermatol. Sci.
    García et al., 1997, Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells., Am. J. Vet. Res.
    Nosál' et al., 2006, On the pharmacology and toxicology of neutrophils., Neuro Endocrinol. Lett.