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FENOLDOPAM Drug Record

  • Summary
  • Interactions
  • Claims
  • FENOLDOPAM CHEMBL588 FDA Approved

    Alternate Names:

    Fenoldopam
    SK-82526
    SK&F-82526
    Corlopam
    67227-56-9
    DB00800
    AC1Q3LHG
    CARLACOR
    BIOMOL-NT_000042
    67227-57-0
    LS-27993
    NCGC00025246-02
    BPBIO1_001265
    PDSP1_001661
    FENOLDOPAM (INN)
    NCGC00025246-03
    6-CHLORO-1-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE-7,8-DIOL
    FENODOPAM MESYLATE
    67287-54-1 (HYDROBROMIDE)
    3341
    188303
    CHEBI:5002
    DAP000254
    67227-57-0 (MESYLATE)
    HMS2090G16
    LOPAC0_000556
    FENOLDOPAMUM [LATIN]
    NCGC00015444-05
    9-CHLORO-5-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE-7,8-DIOL
    L000254
    CARLACOR (TN)
    UNII-INU8H2KAWG
    C07693
    87900-90-1
    PDSP2_001645
    FENOLDOPAM [INN:BAN]
    1H-3-BENZAZEPINE-7,8-DIOL, 6-CHLORO-2,3,4,5-TETRAHYDRO-1-(4-HYDROXYPHENYL)-
    AR-1L4264
    AC1L1FPQ
    D07946
    CID3341
    BRD-A50684349-001-01-5
    FENOLDOPAMUM
    135651054
    939
    9-CHLORO-5-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE-7,8-DIOL;METHANESULFONIC ACID
    9-CHLORANYL-5-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE-7,8-DIOL;METHANESULFONIC ACID
    9-CHLORO-5-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE-7,8-DIOL;MESYLIC ACID
    AB00698256-15
    AB00698256-13
    FT-0641107
    AB2000493
    AB0013872
    I745
    BC220528
    AN-38412
    NCGC00015444-07
    NCGC00015444-06
    NCGC00015444-03
    VA10891
    MCULE-7876003953
    CS-2979
    CCG-204646
    TOX21_110152_1
    AKOS015906543
    TOX21_110152
    HY-B0735
    BDBM60917
    SCHEMBL13287212
    CID_49659
    GTPL939
    SCHEMBL34250
    CORLOPAMREG
    SMR000469190
    SK-82526-J
    CAS-67227-56-9
    MLS001401388
    DSSTOX_GSID_43896
    DSSTOX_RID_80083
    DSSTOX_CID_23896
    NCGC00015444-04
    TVURRHSHRRELCG-UHFFFAOYSA-N

    Drug Info:

    Drug Categories vasodilator agents
    Drug Categories therapeutic uses
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories neurotransmitter agents
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories hypotensive agents
    Drug Categories heterocyclic compounds, 2-ring
    Drug Categories heterocyclic compounds
    Drug Categories dopamine agonists
    Drug Categories dopamine agents
    Drug Categories chemical actions and uses
    Drug Categories cardiovascular system
    Drug Categories cardiovascular agents
    Drug Categories cardiac therapy
    Drug Categories cardiac stimulants excl. cardiac glycosides
    Drug Categories benzazepines
    Drug Categories antihypertensive agents
    Drug Categories adrenergic and dopaminergic agents
    Drug Groups approved
    Drug Type small molecule
    Drug Class antihypertensive agents
    Year of Approval 1997
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antihypertensive agent
    (2 More Sources)

    Publications:

    Zeng et al., 2009, D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression., J. Hypertens.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Dhasmana et al., The role of dopamine (D2), alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat., Pharmacol. Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
  • FENOLDOPAM   DRD1

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:
    Zeng et al., 2009, D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression., J. Hypertens.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Dhasmana et al., The role of dopamine (D2), alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat., Pharmacol. Res.

  • FENOLDOPAM   DRD4

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • FENOLDOPAM   DRD5

    Interaction Types:
    agonist

    Interaction Info:
    Trial Name fenoldopam mesylate, SKF-82526,Corlopam
    Novel drug target Established target

    Publications:
    Zeng et al., 2009, D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression., J. Hypertens.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • FENOLDOPAM   ADRA2B

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • FENOLDOPAM   ADRA2C

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • FENOLDOPAM   ADRA2A

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • FENOLDOPAM   ADRA1B

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.

  • FENOLDOPAM   ADRA1D

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.

  • FENOLDOPAM   ADRA1A

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.

  • DrugBank: DB00800

    • Version: 5.0.8

    Alternate Names:
    FENOLDOPAM DrugBank Drug Name
    67227-56-9 CAS Number
    Corlopam Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories adrenergic and dopaminergic agents

    Publications:
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • TEND: FENOLDOPAM

    • Version: 01-August-2011

    Alternate Names:
    FENOLDOPAM Primary Drug Name

    Drug Info:
    Year of Approval 1997
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: FENOLDOPAM

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antihypertensive agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • TTD: DAP000254

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    FENOLDOPAMUM Drug Synonym
    BRD-A50684349-001-01-5 Drug Synonym
    DB00800 Drug Synonym

    Drug Info:

    Publications:

  • GuideToPharmacologyInteractions: 939

    • Version: 27-September-2017

    Alternate Names:
    FENOLDOPAM GuideToPharmacology Ligand Name
    135651054 PubChem Drug SID

    Drug Info:

    Publications:

  • PubChem: FENOLDOPAM

    • Version: 09-Feb-2016

    Alternate Names:
    FENOLDOPAM pubchem_primary_name
    3341 PubChem CID
    FENOLDOPAMUM Drug Synonym

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25