• DIPYRIDAMOLE CHEMBL932 FDA Approved

    Alternate Names:

    Ofcram PR
    Persantin Ret
    Modaplate
    Dipyridamole
    Persantin
    Cerebrovase 100
    Attia
    Pyridantin
    Vasyrol
    Cerebrovase 25
    Persantine
    RA-8
    Iv Persantine
    C445
    CLERIDIUM
    KURANTIL
    2,6-BIS(DIETHANOLAMINE)-4,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE
    MIOSEN
    CARDOXIL
    EU-0100464
    CARDIOFLUX
    HMS1568M06
    USAF GE-12
    NATYL
    AKOS000509426
    STENOCARDIL
    DIVK1C_000696
    WLN: T66 BN DN GN INJ CCN HCN E- AT6NTJ B2Q F2Q& J- AT6NTJ B2Q F2Q
    S1867_SELLECK
    CHILCOLAN
    IZEKFCXSFNUWAM-UHFFFAOYSA-
    AC-18100
    D2274
    APRICOR
    CORIBON
    LS-66732
    APOTEX BRAND OF DIPYRIDAMOLE
    D004176
    HMS1989N16
    MLS001333724
    DB00975
    NCGC00015385-15
    KBIO2_001484
    NCGC00023914-06
    NOVOPHARM BRAND OF DIPYRIDAMOLE
    HMS502C18
    APO-DIPYRIDAMOLE FC
    LOPAC0_000464
    BERLIN-CHEMIE BRAND OF DIPYRIDAMOLE
    D9766_SIGMA
    CLERIDIUM 150
    BERLIN CHEMIE BRAND OF DIPYRIDAMOLE
    NCI60_005689
    UNII-64ALC7F90C
    CPD000058382
    BIM-0050449.0001
    C24H40N8O4
    AC1Q7CXX
    BIO-0173
    NSC-515776
    NSC515776
    PRESTWICK0_000142
    SPECTRUM3_000402
    THYMIDINE, 3'-AZIDO-5-BROMO-3'-DEOXY-5,6-DIHYDRO-6-METHOXY-
    PROTANGIX
    COROSAN
    CEREBROVASE
    D 9766
    BSPBIO_001924
    APO-DIPYRIDAMOLE SC
    COROXIN
    148864
    SPBIO_002183
    CURANTYL
    DIPYRIDAMOLUM [INN-LATIN]
    NCGC00023914-07
    KBIO1_000696
    EINECS 200-374-7
    S1895_SELLECK
    NCGC00023914-02
    IPRAD BRAND OF DIPYRIDAMOLE
    AC1Q7CXU
    SPECTRUM5_000839
    RA 8
    ASHBOURNE BRAND OF DIPYRIDAMOLE
    BRN 0068373
    3108
    NCGC00023914-05
    BRD-K86301799-001-04-1
    AC1Q7CXW
    SMR000058382
    KBIOSS_001484
    PRESTWICK_145
    2,6-BIS(DIETHANOLAMINO)-4,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE
    SMP2_000208
    NINDS_000696
    MLS001076306
    SPECTRUM_001004
    NCGC00023914-08
    CAS-58-32-2
    PRANDIOL 75
    DIPYRIDAN
    TOCRIS-0691
    PRESTWICK1_000142
    KBIOGR_001123
    STIMOLCARDIO
    NCGC00023914-11
    CARDOXIN
    D00302
    UPCMLD-DP072
    AGILEASE
    PERMILTIN
    BSPBIO_000244
    DYPYRIDAMOL
    AC1L1F6T
    DIPYRIDAMINE
    CURANTIL
    PRESTWICK3_000142
    PERMOLE, PERSANTINE, DIPYRIDAN, DIPYRIDAMOLE
    SPBIO_001003
    NSC 515776
    APO-DIPYRIDAMOLE
    BELMAC BRAND OF DIPYRIDAMOLE
    PYRIMIDO(5,4-D)PYRIMIDINE, 2,6-BIS(BIS(2-HYDROXYETHYL)AMINO)-4,8-DIPIPERIDINO-
    PYRIMIDO(5,4-D)PYRIMIDINE, 2,6-BIS[BIS(2-HYDROXYETHYL)AMINO]-4,8-DIPERIDINO-
    BPBIO1_000270
    AB00051974
    DIPYUDAMINE
    KBIO2_004052
    HMS1791N16
    MLS000028420
    NCGC00023914-09
    PERIDAMOL
    LOPAC-D-9766
    KBIO2_006620
    PIROAN
    58-32-2
    DIPYRIDAMOL
    NCGC00015385-03
    CHEBI:4653
    PRESTWICK2_000142
    BOEHRINGER INGELHEIM BRAND OF DIPYRIDAMOLE
    KBIO3_001144
    NCGC00015385-07
    HMS1920I10
    MOLPORT-001-792-504
    ANGINAL
    JUSTPERTIN
    STENOCARDIOL
    DIPYRIDAMOLUM
    4-26-00-03840 (BEILSTEIN HANDBOOK REFERENCE)
    2-[[2-(BIS(2-HYDROXYETHYL)AMINO)-4,8-DI(PIPERIDIN-1-YL)PYRIMIDO[6,5-E]PYRIMIDIN-
    GULLIOSTIN
    BSPBIO_001554
    NCGC00015385-01
    DAP000013
    HMS2091O18
    PRANDIOL
    BAS 00818792
    NCGC00015385-02
    DIPYRIDAMOLE (JP15/USP/INN)
    NCGC00023914-10
    CID3108
    UPCMLD-DP072:001
    NCGC00023914-04
    SPECTRUM4_000522
    ANTISTENOCARDIN
    DIPYRIDAMOLE [USAN:INN:BAN:JAN]
    DIPYRAMIDOLE
    IDI1_000696
    SPECTRUM2_000972
    2,6-BIS(DIETHANOLAMINO)-4,8-DIPIPERIDINOPYRIMIDO(5,4-D)PYRIMIDINE
    HMS2089N15
    DIPIRIDAMOL
    SPECTRUM1500259
    ZINC00643046
    SAM002264609
    DIPIRIDAMOL [INN-SPANISH]
    CORONARINE
    NOVO-DIPIRADOL
    PERSANTINE (TN)
    CORIDIL
    Persantine Tab 75mg
    Persantine Tab 50mg
    Persantine Tab 25mg
    Persantine Tab 100mg
    Novo-dipiradol Tab 75mg
    Novo-dipiradol Tab 50mg
    Novo-dipiradol Tab 25mg
    Novo-dipiradol Sct 100mg
    Dipyridamole-75
    Dipyridamole-50
    Dipyridamole-25
    Dipyridamole for Injection
    Dipyridamole Injection, USP
    Dipyridamole 75 Tab
    Dipyridamole 50 Tab 50mg
    Dipyridamole 25 Tab 25mg
    Aspirin and Extended-release Dipyridamole
    Aspirin and Extended - Release Dipyridamole Capsules, 25 Mg / 200 mg
    Aspirin and Dipyridamole
    Asasantine Cap
    Apo-dipyridamole-SC Tab 75mg
    Apo-dipyridamole-SC Tab 50mg
    Apo-dipyridamole-SC Tab 25mg
    Apo-dipyridamole-FC Tab 75mg
    Apo-dipyridamole-FC Tab 50mg
    Apo-dipyridamole-FC Tab 25mg
    Aggrenox
    178101509
    4807
    NCGC00015385-12
    INCHI=1/C24H40N8O4/C33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/H33-36H,1-18H2
    ETHANOL,2',2'',2'''-[(4,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)DINITRILO]TETRA-
    ETHANOL,2',2'',2'''-[(4,8-DI-1-PIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)DINITRILO]TETRAKIS-
    ETHANOL, 2,2',2',2'''-((4,8-DI-1-PIPERIDINYLPYRIMIDO(5,4-D)PYRIMIDINE-2,6-DIYL)DINITRILO)TETRAKIS-
    ETHANOL, 2,2',2'',2'''-(4,8-DIPIPERIDINOPYRIMIDO(5,4-D)PYRIMIDINE-2,6-DIYLDINITRILO)TETRA-
    2-[[2-[BIS(2-HYDROXYETHYL)AMINO]-4,8-DI(PIPERIDIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDIN-6-YL]-(2-HYDROXYETHYL)AMINO]ETHANOL;
    2-[[2-[BIS(2-HYDROXYETHYL)AMINO]-4,8-BIS(1-PIPERIDINYL)-6-PYRIMIDO[5,4-D]PYRIMIDINYL]-(2-HYDROXYETHYL)AMINO]ETHANOL
    2-({6-[BIS(2-HYDROXYETHYL)AMINO]-4,8-DIPIPERIDYLPYRIMIDINO[5,4-D]PYRIMIDIN-2-Y L}(2-HYDROXYETHYL)AMINO)ETHAN-1-OL
    2,2',2'',2'''-[(4,8-DIPIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)DINITRILO]TETRAKISETHANOL
    2,2',2'',2'''-[(4,8-DIPIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)DINITRILO]TETRAETHANOL
    2,2',2'',2'''-[(4,8-DIPIPERIDIN-1-YLPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)DINITRILO]TETRAETHANOL
    2,2',2'',2'''-((4,8-DI(PIPERIDIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)BIS(AZANETRIYL))TETRAKIS(ETHAN-1-OL)
    2,2',2'',2'''-((4,8-DI(PIPERIDIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)BIS(AZANETRIYL))TETRAETHANO
    ETHANOL,2',2'',2'''-(4,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYLDINITRILO)TETRA-
    2,2'',2'''-[4,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL]DINITRILOTETRAETHANOL
    PYRIMIDO(5, 2,6-BIS[BIS(2-HYDROXYETHYL)AMINO]-4,8-DIPERIDINO-
    BRD-K86301799-001-24-9
    W-105400
    3B2-0654
    A828156
    AB00051974-19
    AB00051974-18
    54290-EP2308562A2
    54290-EP2305653A1
    54290-EP2298773A1
    54290-EP2277865A1
    J10379
    EN300-70723
    W1467
    FT-0603242
    ST2415551
    AB2000355
    AB0013300
    2,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE
    DIPYRIDAMOLE-SUPPLIED BY SELLECK CHEMICALS
    ZB014732
    ST078856
    HE356097
    H843
    DR003079
    CJ-04389
    BR-76609
    BC213273
    AN-23600
    AK-76609
    AJ-23813
    4CA-0464
    NCGC00015385-18
    NCGC00015385-16
    NCGC00015385-14
    NCGC00015385-13
    NCGC00015385-11
    NCGC00015385-10
    NCGC00015385-09
    NCGC00015385-08
    NCGC00015385-06
    NCGC00015385-05
    NCGC00015385-04
    VA10749
    RTR-020274
    NSC-756743
    NSC-619103
    NC00448
    MP-0582
    MCULE-3112669573
    LP00464
    HS-0041
    CS-2352
    BCP9000613
    TOX21_110133_1
    STL377790
    NSC756743
    MFCD00010555
    CCG-40190
    BBL027781
    ANW-49242
    TOX21_110133
    HY-B0312
    EBD20789
    ZINC643046
    PHARMAKON1600-01500259
    HMS3402N16
    HMS3371J03
    HMS3266J17
    HMS3261M10
    HMS3259C03
    HMS2232E19
    HMS2095M06
    BCPP000256
    IZEKFCXSFNUWAM-UHFFFAOYSA-N
    DIPYRIDAMOLE (JP16/USP/INN)
    CTK8B5592
    BDBM23620
    THYMIDINE,6-DIHYDRO-6-METHOXY-
    GTPL4807
    64ALC7F90C
    MLS002548866
    SCHEMBL16119
    PERMOLE;DIPYRIDAN;PERSANTINE
    CID_3108
    PERMOLE
    PERSANTINEREG
    ETHANOL, 2,2',2'',2'''-((4,8-DIPIPERIDINOPYRIMIDO(5,4-D)PYRIMIDINE-2,6-DIYL)DINITRILO)TETRA-
    2-[[2-[BIS(2-HYDROXYETHYL)AMINO]-4,8-DI(PIPERIDIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDIN-6-YL]-(2-HYDROXYETHYL)AMINO]ETHANOL
    2-[[2-[BIS(2-HYDROXYETHYL)AMINO]-4,8-BIS(1-PIPERIDYL)PYRIMIDO[5,4-D]PYRIMIDIN-6-YL]-(2-HYDROXYETHYL)AMINO]ETHANOL
    2-({6-[BIS(2-HYDROXYETHYL)AMINO]-4,8-BIS(PIPERIDIN-1-YL)-[1,3]DIAZINO[5,4-D]PYRIMIDIN-2-YL}(2-HYDROXYETHYL)AMINO)ETHAN-1-OL
    CS19155
    ETHANOL, 2,2',2'',2'''-[(4,8-DI-1-PIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)DINITRILO]TETRAKIS-
    ETHANOL, 2,2',2'',2'''-((4,8-DI-1-PIPERIDINYLPYRIMIDO(5,4-D)PYRIMIDINE-2,6-DIYL)DINITRILO)TETRAKIS-
    2-({6-[BIS(2-HYDROXYETHYL)AMINO]-4,8-BIS(PIPERIDIN-1-YL)PYRIMIDO[5,4-D][1,3]DIAZIN-2-YL}(2-HYDROXYETHYL)AMINO)ETHAN-1-OL
    2,2',2'',2'''-{[4,8-DI(PIPERIDIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL]DINITRILO}TETRAETHANOL
    DSSTOX_GSID_40668
    DSSTOX_RID_79531
    DSSTOX_CID_20668
    DYPYRIDAMOLE
    2,2',2'',2'''-((4,8-DI(PIPERIDIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)BIS(AZANETRIYL))TETRAETHANOL
    PA449367
    23620
    55390-555-10
    C1CCN(CC1)C2C3C(C(NC(N3)N(CCO)CCO)N4CCCCC4)NC(N2)N(CCO)CCO
    DNC001625
    2244475
    4653
    2997
    46506292
    DIPYIDAMOLE
    (2S)-N-{4-[(DIAMINOMETHYLIDENE)AMINO]BUTYL}-1-[(2S)-4-METHYL-2-PHENYLMETHANESULFONAMIDOPENTANOYL]PYRROLIDINE-2-CARBOXAMIDE
    (2S)-1-[(2S)-2-(BENZYLSULFONYLAMINO)-4-METHYLPENTANOYL]-N-[4-(DIAMINOMETHYLIDENEAMINO)BUTYL]PYRROLIDINE-2-CARBOXAMIDE
    DB04772
    ZINC16051709
    AC1NUV4O
    N-(BENZYLSULFONYL)-L-LEUCYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)-L-PROLINAMIDE
    1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANE
    5494440
    RA8

    Drug Info:

    Year of Approval 1961
    Drug Class platelet aggregation inhibitors
    Drug Class vasodilator agents
    Drug Categories vasodilator agents
    Drug Categories therapeutic uses
    Drug Categories pyrimidines
    Drug Categories platelet aggregation inhibitors excl. heparin
    Drug Categories platelet aggregation inhibitors
    Drug Categories phosphodiesterase inhibitors
    Drug Categories pharmacologic actions
    Drug Categories p-glycoprotein/abcb1 substrates
    Drug Categories p-glycoprotein/abcb1 inhibitors
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories hypotensive agents
    Drug Categories heterocyclic compounds, 1-ring
    Drug Categories heterocyclic compounds
    Drug Categories hematologic agents
    Drug Categories fibrinolytic agents
    Drug Categories enzyme inhibitors
    Drug Categories chemical actions and uses
    Drug Categories cardiovascular agents
    Drug Categories blood and blood forming organs
    Drug Groups approved
    Drug Type small molecule
    Drug Indications antithrombotic
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications anticoagulant
    ATC c01dx(other vasodilators used in cardiac diseases)
    Drug Type drug/small molecule
    ATC b01ac(platelet aggregation inhibitors excl. heparin)
    Drug Categories N/A
    Drug Groups experimental
    (7 More Sources)

    Publications:

    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Fujishige et al., 1999, Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)., J. Biol. Chem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Santini et al., 2005, Hemodynamic effects of inhaled nitric oxide and phosphodiesterase inhibitor (dipyridamole) on secondary pulmonary hypertension following heart valve surgery in adults., Int. J. Cardiol.
    Kulkarni et al., 2004, Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects., Methods Find Exp Clin Pharmacol
    Jackson et al., 2007, Characterization of renal ecto-phosphodiesterase., J. Pharmacol. Exp. Ther.
    Kruuse et al., 2006, Dipyridamole may induce migraine in patients with migraine without aura., Cephalalgia
    Hosoi et al., 1998, Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP., Int. J. Oncol.
    Simiti et al., Increased plasma levels of interleukin-8 in patients with unstable angina pectoris., Rom J Intern Med
    Hellwig et al., 1991, Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine., Mol. Pharmacol.