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CLOZAPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CLOZAPINE CHEMBL42 FDA Approved

    Alternate Names:

    Zaponex
    Clozapine
    Clozaril
    Fazaclo
    HF-1854
    Fazaclo Odt
    C28936
    Zopin
    Ziproc
    Zapine
    Zapenia
    Zapen
    Versacloz
    Uspen
    Tanyl
    Syzopin
    Syclop
    Sizopril
    Sizopin
    Sequax
    Sensipin
    Sandoz Clozapine
    Refraxol
    Refract
    PMS-clozapine
    Mezapin
    Luften
    Lozapin
    Lodux
    Leponex
    Lapenax
    Lanolept
    Gen-clozapine
    Clorazem
    Clopsine
    Clopine
    Clopin
    Clonex
    Cloment
    Azaleptine
    Auro-clozapine
    Aa-clozapine
    5786-21-0
    Clozapina
    DB00363
    22869
    2716
    46506474
    ASALEPTIN
    57664-345-88
    C06924
    D00283
    7847349
    CN1CCN(CC1)C2=NC3CC(CCC3NC4C2CCCC4)CL
    2818
    3766
    IPROX
    2240669
    PA449061
    CLOZAPIN
    DAP000029
    LEPOTEX
    BC204168
    AN-16004
    NCGC00188978-01
    NCGC00022902-12
    NCGC00015254-20
    NCGC00015254-18
    NCGC00015254-16
    NCGC00015254-15
    NCGC00015254-14
    NCGC00015254-13
    NCGC00015254-11
    NCGC00015254-10
    NCGC00015254-09
    NCGC00015254-08
    NCGC00015254-06
    NCGC00015254-05
    NCGC00015254-04
    NSC-757429
    NC00667
    MCULE-3665900006
    LP00276
    CS-0644
    CLOZAPINE-SUPPLIED BY SELLECK CHEMICALS
    TOX21_110113_1
    ZINC19796155
    NSC757429
    CCG-39881
    CC0176
    BDBM50001884
    ANW-42470
    TOX21_110113
    ZINC3872123
    PHARMAKON1600-01500685
    HMS3402P12
    HMS3371H05
    HMS3266A10
    HMS3260H14
    HMS3259J17
    HMS2235E19
    HMS2096E21
    CLOZAPINE [USAN:USP:INN:BAN]
    AOB5635
    QZUDBNBUXVUHMW-UHFFFAOYSA-
    CTK6I2968
    BDBM22869
    SCHEMBL33323
    REGID_FOR_CID_2818
    INCHI=1/C18H19CLN4/C1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/H2-7,12,20H,8-11H2,1H3
    6-CHLORO-10-(4-METHYLPIPERAZIN-1-YL)-2,9-DIAZATRICYCLO[9.4.0.03,8]PENTADECA-1(11),3,5,7,9,12,14-HEPTAENE
    6-CHLORO-10-(4-METHYLPIPERAZIN-1-YL)-2,9-DIAZATRICYCLO[9.4.0.0^{3,8}]PENTADECA-1,3(8),4,6,10,12,14-HEPTAENE
    6-CHLORO-10-(4-METHYLPIPERAZIN-1-YL)-2,9-DIAZATRICYCLO[9.4.0.0?,?]PENTADECA-1,3(8),4,6,10,12,14-HEPTAENE
    6-CHLORO-10-(4-METHYLPIPERAZIN-1-YL)-2,9-DIAZATRICYCLO[9.4.0.0(3),?]PENTADECA-1,3(8),4,6,10,12,14-HEPTAENE
    CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
    8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE(CLOPAZINE)
    8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE(CIOZAPINE)
    8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE( CLOZEPINE )
    8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE (CLOZAPINE)
    3-HYDROXY-2-PHENYL-PROPIONIC ACID 8-METHYL-8-AZA-BICYCLO[3.2.1]OCT-3-YL ESTER
    8-CHLORO-11-(4-METHYLPIPERAZIN-1-YL)-10H-DIBENZO[B,E][1,4]DIAZEPINE
    8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-10H-DIBENZO[B,E][1,4]DIAZEPINE
    3-CHLORO-6-(4-METHYLPIPERAZIN-1-YL)-11H-BENZO[B][1,4]BENZODIAZEPINE
    8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
    I06-0047
    BRD-K37289225-001-09-1
    L013417
    L000195
    DSSTOX_GSID_22855
    DSSTOX_RID_76759
    C 6305
    DSSTOX_CID_2855
    5H-DIBENZO[B,E][1,4]DIAZEPINE, 8-CHLORO-11-(4-METHYL-1-PIPERAZINYL)-
    3-CHLORO-6-(4-METHYLPIPERAZIN-1-YL)-5H-BENZO[B][1,4]BENZODIAZEPINE
    LX 100-129
    FT-0082373
    EU-0100276
    SMR000058365
    SAM002548976
    AB00052158-14
    AB00052158-13
    W-2845
    EN300-52510
    FT-0600382
    D-107
    C2547
    TC-063560
    AB1009321
    AB0013069
    SAM002589962
    PL001733
    HY-14539
    H482
    LS-60881
    CPD000058365
    NCGC00022902-13
    NCGC00022902-11
    NCGC00022902-10
    NCGC00022902-09
    NCGC00022902-08
    NCGC00022902-07
    NCGC00022902-06
    NCGC00022902-05
    NCGC00022902-04
    NCGC00022902-02
    NCGC00015254-17
    NCGC00015254-12
    NCGC00015254-07
    NCGC00015254-03
    NCGC00015254-02
    NCGC00015254-01
    AKOS005064444
    AR-1I2412
    AC-280
    5H-DIBENZO(B,E)(1,4)DIAZEPINE, 8-CHLORO-11-(4-METHYL-1-PIPERAZINYL)-
    HMS2092I16
    HMS2089L13
    HMS1989P12
    HMS1921C16
    HMS1791P12
    HMS1569E21
    HMS1361P12
    BIO2_000790
    BIO2_000310
    BIO1_001414
    BIO1_000925
    BIO1_000436
    QZUDBNBUXVUHMW-UHFFFAOYSA-N
    MOLPORT-001-728-041
    NINDS_000343
    LEX-123
    KBIO3_002979
    KBIO3_000620
    KBIO3_000619
    KBIO2_005735
    KBIO2_005446
    KBIO2_003167
    KBIO2_002878
    KBIO2_000599
    KBIO2_000310
    KBIO1_000343
    HMS501B05
    MLS001077282
    MLS000028472
    SPECTRUM1500685
    SPBIO_002340
    SPBIO_000798
    CAS-5786-21-0
    DIVK1C_000343
    C6305_SIGMA
    CLOZAPINE [USAN:INN:BAN]
    KBIOSS_000599
    KBIOSS_000310
    KBIOGR_001336
    KBIOGR_000310
    CLOZAPINE (JAN/USP/INN)
    BRN 0764984
    KS-1166
    HF1854
    LOPAC-C-6305
    EINECS 227-313-7
    SPECTRUM4_000898
    SPECTRUM3_001828
    SPECTRUM2_000919
    PRESTWICK1_000350
    PRESTWICK0_000350
    AC1Q3ZWP
    AC1Q3OPZ
    AC1L1EJE
    TOCRIS-0444
    SPECTRUM_000139
    8-CHLORO-11-(4-METHYLPIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
    HSDB 6478
    3-CHLORO-6-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
    8-CHLORO-11-(4-METHYLPIPERAZINO)-5H-DIBENZO[B,E][1,4]DIAZEPINE
    3B3-036001
    W-105432
    T7100235
    D003024
    SCHEMBL8397
    GTPL38
    J60AR2IKIC
    CLOZAPINE, CLOZARIL, AZALEPTIN, LEPONEX, FAZACLO, FROIDIR, DENZAPINE, ZAPONEX
    CID2818
    KLOZAPOL
    AZALEPTIN
    CLORAZILREG
    S2459_SELLECK
    CHEBI:3766
    CCRIS 9171
    HF 1854
    PRESTWICK_693
    C18H19CLN4
    CLOZARIL (TN)
    CLOZAPINA [INN-SPANISH]
    UNII-J60AR2IKIC
    CLOZAPINUM [INN-LATIN]
    W-801
    CLOZAPINE(TAUTOMER)
    CLOZAPINUM
    CLORAZIL
    135650115
    38
    178100616
    [125I]αCGRP (HUMAN)

    Drug Info:

    Drug Categories tranquilizing agents
    Drug Categories therapeutic uses
    Drug Categories serotonin antagonists
    Drug Categories serotonin agents
    Drug Categories psychotropic drugs
    Drug Categories psycholeptics
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories p-glycoprotein/abcb1 substrates
    Drug Categories neurotransmitter agents
    Drug Categories nervous system
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories moderate risk qtc-prolonging agents
    Drug Categories hypotensive agents
    Drug Categories hyperglycemia-associated agents
    Drug Categories heterocyclic compounds, 3-ring
    Drug Categories heterocyclic compounds
    Drug Categories gaba antagonists
    Drug Categories gaba agents
    Drug Categories dibenzazepines
    Drug Categories diazepines, oxazepines, thiazepines and oxepines
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a inhibitors
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp2e1 inhibitors
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (moderate)
    Drug Categories cytochrome p-450 cyp2d6 inhibitors
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2c9 inhibitors
    Drug Categories cytochrome p-450 cyp2c8 substrates
    Drug Categories cytochrome p-450 cyp2c19 substrates
    Drug Categories cytochrome p-450 cyp2c19 inhibitors
    Drug Categories cytochrome p-450 cyp2a6 substrates
    Drug Categories cytochrome p-450 cyp1a2 substrates
    Drug Categories cytochrome p-450 cyp1a2 inhibitors (weak)
    Drug Categories cytochrome p-450 cyp1a2 inhibitors
    Drug Categories chemical actions and uses
    Drug Categories central nervous system depressants
    Drug Categories central nervous system agents
    Drug Categories antipsychotic agents (second generation [atypical])
    Drug Categories antipsychotic agents
    Drug Categories antiemetics antagonists
    Drug Categories alpha1 antagonists
    Drug Groups approved
    Drug Type small molecule
    Drug Class antipsychotic agents
    Year of Approval 1989
    FDA Approval 1989
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    ATC n05ah(diazepines
    Drug Type drug/small molecule
    (7 More Sources)

    Publications:

    Kuballa et al., Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine., Pharmacol Rep
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Nakane et al., 2005, 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist., Neuropharmacology
    Zhao et al., 2005, Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine., Int. J. Neurosci.
    Glatt et al., 2003, Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis., Biol. Psychiatry
    Patel et al., 2003, Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina., Neuropharmacology
    Broderick et al., 2004, Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Heiser et al., 2004, Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro., Prog. Neuropsychopharmacol. Biol. Psychiatry
    McDonald et al., 2003, Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning., Psychopharmacology (Berl.)
    Reist et al., 2004, Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr., Mol. Psychiatry
    Goldstein, 1999, Quetiapine fumarate (Seroquel): a new atypical antipsychotic., Drugs Today
    Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
    Arranz et al., 1996, Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine., Neurosci. Lett.
    Travis et al., 1998, 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine. A SPET study using the novel 5-HT2A ligand 123I-5-I-R-91150., Br J Psychiatry
    Lipska et al., 2003, Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs., Eur. J. Neurosci.
    Takano et al., 2006, Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Stonehouse et al., 2005, Bromocriptine and clozapine regulate dopamine 2 receptor gene expression in the mouse striatum., J. Mol. Neurosci.
    Green et al., 2002, Treatment of schizophrenia and comorbid substance use disorder., Curr Drug Targets CNS Neurol Disord
    Weizman et al., 2003, The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms., Eur. J. Pharmacol.
    Young et al., 2004, Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele., Br J Psychiatry
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Hagino et al., 2002, Effects of clozapine on the efflux of serotonin and dopamine in the rat brain: the role of 5-HT1A receptors., Can. J. Physiol. Pharmacol.
    Zahorodna et al., 2004, The influence of repeated administration of clozapine and haloperidol on the effects of the activation of 5-HT(1A), 5-HT(2) and 5-HT(4) receptors in rat frontal cortex., J. Physiol. Pharmacol.
    Tomić et al., 2004, Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential., Bioorg. Med. Chem. Lett.
    Newman-Tancredi et al., 2003, Comparison of hippocampal G protein activation by 5-HT(1A) receptor agonists and the atypical antipsychotics clozapine and S16924., Naunyn Schmiedebergs Arch. Pharmacol.
    Chou et al., 2003, Occupancy of 5-HT1A receptors by clozapine in the primate brain: a PET study., Psychopharmacology (Berl.)
    Sodhi et al., 2005, A rapid new assay to detect RNA editing reveals antipsychotic-induced changes in serotonin-2C transcripts., Mol. Pharmacol.
    Navailles et al., 2006, Clozapine and haloperidol differentially alter the constitutive activity of central serotonin2C receptors in vivo., Biol. Psychiatry
    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
    Roegge et al., 2007, Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine., Pharmacol. Biochem. Behav.
    Adachi et al., 2006, Suppression of ischemia/reperfusion liver injury by histamine H4 receptor stimulation in rats., Eur. J. Pharmacol.
    Sugata et al., 2007, Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses., Immunology
    Smits et al., 2006, Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives., J. Med. Chem.
    Chetty et al., 2007, CYP-mediated clozapine interactions: how predictable are they?, Curr. Drug Metab.
    Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci
    Shao et al., 2006, Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells., J Psychiatry Neurosci
    Szuster-Ciesielska et al., Neuroleptics modulate cytokine and reactive oxygen species production in blood leukocytes of healthy volunteers., Arch. Immunol. Ther. Exp. (Warsz.)
    Kobayashi et al., 2000, Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes., Br. J. Pharmacol.
    Atmaca et al., 2003, Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics., J Clin Psychiatry
    Lara et al., 2001, Chronic treatment with clozapine, but not haloperidol, increases striatal ecto-5'-nucleotidase activity in rats., Neuropsychobiology
    Kang et al., 2004, The effects of clozapine on the GSK-3-mediated signaling pathway., FEBS Lett.
    Schmitt et al., 2003, Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain., Neurosci. Lett.
    Wittmann et al., 2005, Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases., J. Pharmacol. Exp. Ther.
    Lieberman et al., 1994, Predictors of response to clozapine., J Clin Psychiatry
    Kontkanen et al., 2002, Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex., Neuropsychopharmacology
  • CLOZAPINE   DRD1

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name -

    Publications:
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • CLOZAPINE   HTR2C

    Interaction Types:
    antagonist

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Inverse agonist

    Publications:
    Sodhi et al., 2005, A rapid new assay to detect RNA editing reveals antipsychotic-induced changes in serotonin-2C transcripts., Mol. Pharmacol.
    Navailles et al., 2006, Clozapine and haloperidol differentially alter the constitutive activity of central serotonin2C receptors in vivo., Biol. Psychiatry

  • CLOZAPINE   CALCRL

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • CLOZAPINE   DRD5

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • CLOZAPINE   HTR1F

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:

  • CLOZAPINE   HTR2B

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • CLOZAPINE   HTR5A

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:

  • CLOZAPINE   SERPINA3

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False

    Publications:

  • CLOZAPINE   TAP2

    Interaction Types:
    agonist

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    Publications:

  • CLOZAPINE   DRD4

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name -

    Publications:
    Kuballa et al., Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine., Pharmacol Rep
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Nakane et al., 2005, 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist., Neuropharmacology

  • CLOZAPINE   HTR2A

    Interaction Types:
    antagonist

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Trial Name -

    Publications:
    Broderick et al., 2004, Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Heiser et al., 2004, Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro., Prog. Neuropsychopharmacol. Biol. Psychiatry
    McDonald et al., 2003, Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning., Psychopharmacology (Berl.)

  • CLOZAPINE   DRD2

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    Publications:
    Lipska et al., 2003, Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs., Eur. J. Neurosci.
    Takano et al., 2006, Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Stonehouse et al., 2005, Bromocriptine and clozapine regulate dopamine 2 receptor gene expression in the mouse striatum., J. Mol. Neurosci.

  • CLOZAPINE   DRD3

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   HTR1A

    Interaction Types:
    agonist
    antagonist

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    Publications:
    Hagino et al., 2002, Effects of clozapine on the efflux of serotonin and dopamine in the rat brain: the role of 5-HT1A receptors., Can. J. Physiol. Pharmacol.
    Zahorodna et al., 2004, The influence of repeated administration of clozapine and haloperidol on the effects of the activation of 5-HT(1A), 5-HT(2) and 5-HT(4) receptors in rat frontal cortex., J. Physiol. Pharmacol.
    Tomić et al., 2004, Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential., Bioorg. Med. Chem. Lett.

  • CLOZAPINE   HTR1B

    Interaction Types:
    agonist
    antagonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   HTR1D

    Interaction Types:
    agonist
    antagonist

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   HTR1E

    Interaction Types:
    agonist
    antagonist

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   HTR3A

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   HTR6

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   HTR7

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.

  • CLOZAPINE   HRH1

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name -

    Publications:
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Roegge et al., 2007, Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine., Pharmacol. Biochem. Behav.
    Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry

  • CLOZAPINE   HRH4

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name -

    Publications:
    Adachi et al., 2006, Suppression of ischemia/reperfusion liver injury by histamine H4 receptor stimulation in rats., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sugata et al., 2007, Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses., Immunology

  • CLOZAPINE   ADRA1A

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   ADRA1B

    Interaction Types:
    antagonist

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   ADRA2A

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   ADRA2B

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   ADRA2C

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   CHRM1

    Interaction Types:
    antagonist
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   CHRM2

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   CHRM3

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   CHRM4

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   CHRM5

    Interaction Types:
    antagonist

    Interaction Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

  • CLOZAPINE   CALY

    Interaction Types:
    unknown

    Interaction Info:

    Publications:
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • CLOZAPINE   CYP3A4

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Chetty et al., 2007, CYP-mediated clozapine interactions: how predictable are they?, Curr. Drug Metab.

  • CLOZAPINE   FASN

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci

  • CLOZAPINE   GDNF

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Shao et al., 2006, Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells., J Psychiatry Neurosci

  • CLOZAPINE   IL2

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Szuster-Ciesielska et al., Neuroleptics modulate cytokine and reactive oxygen species production in blood leukocytes of healthy volunteers., Arch. Immunol. Ther. Exp. (Warsz.)

  • CLOZAPINE   KCNJ3

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Kobayashi et al., 2000, Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes., Br. J. Pharmacol.

  • CLOZAPINE   LEP

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Atmaca et al., 2003, Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics., J Clin Psychiatry

  • CLOZAPINE   NT5E

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Lara et al., 2001, Chronic treatment with clozapine, but not haloperidol, increases striatal ecto-5'-nucleotidase activity in rats., Neuropsychobiology

  • CLOZAPINE   PIK3CG

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Kang et al., 2004, The effects of clozapine on the GSK-3-mediated signaling pathway., FEBS Lett.

  • CLOZAPINE   SLC1A1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Schmitt et al., 2003, Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain., Neurosci. Lett.

  • CLOZAPINE   SRC

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Wittmann et al., 2005, Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases., J. Pharmacol. Exp. Ther.

  • CLOZAPINE   PRL

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Lieberman et al., 1994, Predictors of response to clozapine., J Clin Psychiatry

  • CLOZAPINE   JUND

    Interaction Types:
    n/a

    Interaction Info:

    Publications:
    Kontkanen et al., 2002, Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex., Neuropsychopharmacology

  • CLOZAPINE   DTNBP1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • CLOZAPINE   ANKK1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • CLOZAPINE   CYP2C19

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • CLOZAPINE   MC4R

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • CLOZAPINE   ABCB1

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • CLOZAPINE   FAAH

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • CLOZAPINE   GFRA2

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • CLOZAPINE   CYP2D6

    Interaction Types:
    n/a

    Interaction Info:

    Publications:

  • DrugBank: DB00363

    • Version: 5.0.8

    Alternate Names:
    CLOZAPINE DrugBank Drug Name
    Clozapina Drug Synonym
    Clozapine Drug Synonym

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories alpha1 antagonists

    Publications:
    Kuballa et al., Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine., Pharmacol Rep
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Nakane et al., 2005, 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist., Neuropharmacology

  • TEND: CLOZAPINE

    • Version: 01-August-2011

    Alternate Names:
    CLOZAPINE Primary Drug Name

    Drug Info:
    Year of Approval 1989
    Drug Class antipsychotic agents

    Publications:

  • PharmGKB: PA449061

    • Version: 12-July-2012

    Alternate Names:
    LEPONEX Drug Trade Name
    LEPOTEX Drug Trade Name
    FAZACLO ODT Drug Trade Name

    Drug Info:
    Drug Type drug/small molecule
    ATC n05ah(diazepines

    Publications:

  • TdgClinicalTrial: CLOZAPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antipsychotic Agents
    Drug Class small molecule
    FDA Approval 1989

    Publications:

  • NCI: CLOZAPINE

    • Version: 14-September-2017

    Alternate Names:
    C28936 NCI drug code

    Drug Info:

    Publications:
    Chetty et al., 2007, CYP-mediated clozapine interactions: how predictable are they?, Curr. Drug Metab.
    Lipska et al., 2003, Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs., Eur. J. Neurosci.
    Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci

  • GuideToPharmacologyInteractions: 3766

    • Version: 27-September-2017

    Alternate Names:
    [125I]αCGRP (HUMAN) GuideToPharmacology Ligand Name
    178100616 PubChem Drug SID

    Drug Info:

    Publications:

  • TTD: DAP000029

    • Version: 4.3.02 (25-August-2011)

    Alternate Names:
    HMS1921C16 Drug Synonym
    SPECTRUM_000139 Drug Synonym
    KBIOGR_000310 Drug Synonym

    Drug Info:

    Publications:

  • PubChem: CLOZAPINE

    • Version: 09-Feb-2016

    Alternate Names:
    CLOZAPINE pubchem_primary_name
    2818 PubChem CID
    LEPONEX Drug Synonym

    Drug Info:

    Publications:

  • GuideToPharmacologyInteractions: 38

    • Version: 27-September-2017

    Alternate Names:
    CLOZAPINE GuideToPharmacology Ligand Name
    135650115 PubChem Drug SID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL42

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Clozapine

    • Version: 15-September-2017

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v3.0.2 - sha1 ec916b2) • Last updated 2018-01-25