• CALCITRIOL CHEMBL846 FDA ApprovedAntineoplastic

    Alternate Names:

    Calcitriol
    Silkis
    1alpha,25-dihydroxycholecalciferol
    1alpha,25-dihydroxyvitamin D3
    Rocaltrol
    Calcijex
    Vectical
    Topitriol
    Dihydroxyvitamin D 3
    Dihydroxycholecalciferol
    Ro-215535
    C330
    4817
    DECOSTRIOL
    DB00136
    0004-0143-23
    25-(OH)2D3
    DAP000289
    2245686
    PA448717
    25-DIHYDROXYCHOLECALCIFEROL
    17823
    25-(OH)<SUB>2</SUB>D3
    D00129
    CALCITRIOL ORAL SOLUTION
    134070
    C01673
    (5Z,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1.ALPHA.,3.BETA.,25-TRIOL
    (5E,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL
    (1?,3?,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL
    BRD-K27316855-001-06-7
    3B2-0461
    AB00639957-06
    62019-EP2308839A1
    62019-EP2308828A2
    62019-EP2298772A1
    62019-EP2292592A1
    W-5161
    1ALPHA,25-DIHYDROXY-5,6-TRANS-VITAMIN D3
    CAS-32222-06-3
    5,6-TRANS-1ALPHA,25-DIHYDROXYVITAMIN D3
    OR257676
    OR257675
    OR109383
    HY-10002
    DR002536
    BC208534
    1.ALPHA.,25-DIHYDROXYVITAMIN D(SUB 3)
    CALCITRIOL-SUPPLIED BY SELLECK CHEMICALS
    NSC-749776
    NC00251
    DB05314
    CS-0388
    CCG-101001
    CALCITRIOL [USAN:USP:INN:BAN:JAN]
    BCP9000474
    ZINC100015048
    AKOS015961898
    CALCITRIOL SPECIFIED IMPURITY A [EP]
    NSC749776
    BDBM50200182
    TOX21_111988
    ACT06832
    73837-24-8
    HMS3402A09
    HMS2232D18
    BCPP000304
    GMRQFYUYWCNGIN-NKMMMXOESA-N
    CAS NUMBER 32222-06-3
    HMDB01903
    GTPL2779
    CALCITRIOL (JAN/USAN/INN)
    CALCITRIOL (JAN/USP/INN)
    DSSTOX_GSID_22722
    FXC9231JVH
    DSSTOX_RID_76700
    CALCITRIOL IMPURITY A [EP]
    SCHEMBL3245
    SYNTHETIC VITAMIN D ANALOG
    DSSTOX_CID_2722
    PUBCHEM19327
    PUBCHEM18818
    CID5280453
    SAM001246772
    CPD000466393
    (1R,3S,5Z)-5-[(2E)-2-[(1R,3AS,7AR)-1-[(1R)-5-HYDROXY-1,5-DIMETHYL-HEXYL]-7A-METHYL-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLENE-CYCLOHEXANE-1,3-DIOL
    1,25-DIHYDROXY-5,6-TRANS-VITAMIN D3
    TRANS-CALCITRIOL
    PANBONIS
    ROCALTROLREG
    CHOLECALCI
    CALCIJEXREG
    UNII-I1L29CLX3C
    (1R,3S,5Z)-5-{2-[(1R,3AS,4E,7AR)-1-[(2R)-6-HYDROXY-6-METHYLHEPTAN-2-YL]-7A-METHYL-OCTAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE}-4-METHYLIDENECYCLOHEXANE-1,3-DIOL
    (1R,3S)-5-{2-[(1R,3AS,7AR)-1-((R)-5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL
    9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, (1.ALPHA.,3.BETA,.5Z,7E)- & CD4
    9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, (1.ALPHA.,3.BETA,.5Z,7E)-
    9,10-SECO(5Z,7E)-5,7,10(19)-CHOLESTATRIENE-1ALPHA, 3BETA, 25-TRIOL
    (5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1-ALPHA,3-BETA,25-TRIOL
    CALCIJEX, SILKIS, ROCALTROL, TOPITRIOL, CHOLECALCIFEROL,CALCITRIOL
    (3B,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENETRIOL
    1.ALPHA.,25-DIHYDROXY-26,27-HEXADEUTEROVITAMIN D3
    (1R,3S,5Z)-5-[(2E)-2-[(1R,3AS,7AR)-1-[(2R)-6-HYDROXY-6-METHYLHEPTAN-2-YL]-7A-METHYL-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENECYCLOHEXANE-1,3-DIOL
    1,25D3
    (5Z,7E)-(1S,3R)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL
    (1ALPHA,3BETA,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL
    9,10-SECO(5Z,7E)-5,7,10(19)-CHOLESTATRIENE-1ALPHA,3BETA,25-TRIOL
    (5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL
    (1S,3R,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL
    SMR000466393
    LS-53093
    1,25(OH)2D3 & CD4
    NCGC00161327-01
    IDI1_033757
    CD-2027
    AC-1859
    1-ALPHA,-1,25-DIHYDROXYVITAMIN D3
    ZINC03924790
    LMST03020258
    9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, (1ALPHA,3BETA,5Z,7E)-
    1A,25-(OH)2D3
    U 49562
    HMS2089N03
    HMS2051F06
    HMS1989A09
    HMS1791A09
    HMS1361A09
    CALCITRIOL [USAN:INN:BAN:JAN]
    (1S,3R,5Z,7E)-9,10-SECOCHOLESTA-5,7,10-TRIENE-1,3,25-TRIOL
    MOLPORT-002-045-698
    BCBCMAP01_000160
    17936_SIGMA
    17936_FLUKA
    BML2-E03
    1A,25-DIHYDROXYCHOLECALCIFEROL
    MLS001424122
    MLS000759536
    AMBAP32222-06-3
    D1530_SIGMA
    20-EPI-1ALPHA,25-DIHYDROXYCHOLECALIFEROL
    BSPBIO_001287
    1,25-DIHYDROXY VITAMIN D3
    NCGC00161327-04
    CHOLECALCIFEROL, 1-ALPHA,25-DIHYDROXY-
    1ALPHA,25(OH)2-D3
    1A,25-DIHYDROXYVITAMIN D3
    83306-47-2
    69878-52-0
    125338-24-1
    1000873-74-4
    1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-((2E)-2-((1R,3AS,7AS)-OCTAHYDRO-1-((1R)-5-HYDROXY-1,5-DIMETHYLHEXYL)-7A-METHYL-4H-INDEN-4-YLIDENE)ETHYLIDENE)-, (1R,3S,5E)-
    (1R,3S,Z)-5-(2-((1R,3AS,7AR,E)-1-((R)-6-HYDROXY-6-METHYLHEPTAN-2-YL)-7A-METHYLOCTAHYDRO-4H-INDEN-4-YLIDENE)ETHYLIDENE)-4-METHYLENECYCLOHEXANE-1,3-DIOL
    (1R,3S,Z)-5-((E)-2-((1R,3AS,7AR)-1-((R)-6-HYDROXY-6-METHYLHEPTAN-2-YL)-7A-METHYLHEXAHYDRO-1H-INDEN-4(2H)-YLIDENE)ETHYLIDENE)-4-METHYLENECYCLOHEXANE-1,3-DIOL
    9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, (1ALPHA,3BETA,5E,7E)-
    9,?10-?SECOCHOLESTA-?5Z,?7E,?10(19)-?TRIENE-?1ALPHA,?3BETA,?25-?TRIOL
    1ALPHA,25-DIHYDROXYVITAMIN D3 / 1ALPHA,25-DIHYDROXYCHOLECALCIFEROL / CALCITRIOL
    (5Z,7E)-(1S,3R)-9,10-SECO-5,7,10(19)-CHOLESTATRIENE-1,3,25-TRIOL
    MC-1288
    VITAMIN D3, 1ALPHA, 25-DIHYDROXY-
    UNII-FXC9231JVH
    1,25-DIHYDROXY-20-EPI-VITAMIN D3
    MC1288
    DN 101
    EINECS 250-963-8
    SPECTRUM5_002061
    1,25(OH)2-20EPI-D3
    AC1NQX1S
    1DB1
    HSDB 3482
    CHEBI:17823
    S1466_SELLECK
    CCRIS 5522
    1ALPHA,25-DIHYDROXYVITAMIN D
    1,25 DIHYDROXYCHOLECALCIFEROL
    1,25-DIHYDROXYCHOLECALIFEROL
    ROCALTROL (TN)
    VIT D
    CALCITRIOLUM [INN-LATIN]
    TOPTRIOL
    ASENTAR
    DN-101
    1ALPHA,25(OH)2D3
    1,25-DIHYDROXYVITAMIN D3
    CALCITRIOLUM
    1,25-DIHYDROXYVITAMIN D
    1,25-DIHYDROXYCHOLECALCIFEROL
    1,25-DHCC
    DIHYDROXYVITAMIN D3
    32222-06-3
    SOLTRIOL
    5280453
    PA165817516
    13019066
    1,25-DIHYDROXYVITAMIND3
    SCHEMBL8607255
    32511-63-0
    9953732
    (5E)-5-[(2Z)-2-[1-(6-HYDROXY-6-METHYLHEPTAN-2-YL)-7A-METHYL-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENECYCLOHEXANE-1,3-DIOL
    9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, (3.BETA.,5Z,7E)-
    9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3.BETA.,25-TRIOL
    (5E,7Z)-9,10-SECOCHOLESTA-5,7,10-TRIENE-1,3,25-TRIOL #
    GMRQFYUYWCNGIN-NGHQTVFFSA-N
    AC1NSXJ6
    5371993
    AR-1A1585
    ZINC3924790
    KST-1A3874
    (1S,3R)-9,10-SECOCHOLESTA-5,7,10-TRIENE-1,3,25-TRIOL
    10873438
    59072033
    135651370
    2779
    Rocaltrol Oral Solution 1mcg/ml
    Rocaltrol Cap 0.5mcg
    Rocaltrol Cap 0.25mcg
    Calcitriol-odan
    Calcitriol Injection USP
    Calcitriol Injection
    5-{2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
    1α,25-dihydroxyvitamin D3
    1α,25-dihydroxycholecalciferol
    (1R,3S,E)-5-((E)-2-((1R,3AS,7AR)-1-((R)-6-HYDROXY-6-METHYLHEPTAN-2-YL)-7A-METHYLDIHYDRO-1H-INDEN-4(2H,5H,6H,7H,7AH)-YLIDENE)ETHYLIDENE)-4-METHYLENECYCLOHEXANE-1,3-DIOL
    (1R,3S,5E)-5-[(2E)-2-[(1R,3AS,7AR)-1-[(2R)-6-HYDROXY-6-METHYLHEPTAN-2-YL]-7A-METHYL-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENECYCLOHEXANE-1,3-DIOL
    (1R,3S,5E)-4-METHYLENE-5-[(2E)-2-[(1R,3AS,7AS)-OCTAHYDRO-1-[(1R)-5-HYDROXY-1,5-DIMETHYLHEXYL]-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-1,3-CYCLOHEXANEDIOL
    (5E)-1ALPHA,25-DIHYDROXYVITAMIN D3 / (5E)-1ALPHA,25-DIHYDROXYCHOLECALCIFEROL
    (1|A,3|A,5E,7E)- 9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL
    (5Z,7Z)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL
    (5E,7Z)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL
    (5E,7E)-(1S,3R)-9,10-SECO-5,7,10(19)-CHOLESTATRIENE-1,3,25-TRIOL
    (1S,3R,5Z,7E)-9,10-SECO-5,7,10(19)-CHOLESTATRIENE-1,3,25-TRIOL
    BRD-K27316855-001-02-6
    AB0200125
    1|A,25-DIHYDROXY-5,6-TRANS-VITAMIN D3
    5,6-TRANS-1|A,25-DIHYDROXYVITAMIN D3
    (5E)-1ALPHA,25-DIHYDROXYCHOLECALCIFEROL
    NCGC00179229-01
    ZINC100031094
    1|A,25-DIHYDROXYVITAMIN D2 SOLUTION
    LMST03020265
    1|A,25-DIHYDROXYCALCIFEROL SOLUTION
    CS-M0064
    1|A,25-DIHYDROXYVITAMIN D3
    BIDD:GT0500
    I1L29CLX3C
    AC1NR2X6
    5,6-TRANS-CALCITRIOL
    1|A,25-DIHYDROXYCHOLECALCIFEROL
    5283740

    Drug Info:

    ATC d05ax(other antipsoriatics for topical use)
    Drug Type drug/small molecule
    ATC a11cc(vitamin d and analogues)
    Drug Indications antineoplastic agent
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antipsoriatic agent
    Drug Class antiosteoperosis agent
    Year of Approval 1978
    Drug Class antihypocalcemic agents
    Drug Categories N/A
    Drug Groups investigational
    Drug Type small molecule
    Drug Categories vitamins
    Drug Categories vitamin d
    Drug Categories vasoconstrictor agents
    Drug Categories therapeutic uses
    Drug Categories sterols
    Drug Categories steroids
    Drug Categories secosteroids
    Drug Categories polycyclic compounds
    Drug Categories physiological phenomena
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories micronutrients
    Drug Categories membrane transport modulators
    Drug Categories membrane lipids
    Drug Categories lipids
    Drug Categories hydroxycholecalciferols
    Drug Categories growth substances
    Drug Categories food and beverages
    Drug Categories food
    Drug Categories dihydroxycholecalciferols
    Drug Categories diet, food, and nutrition
    Drug Categories dermatologicals
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a4 inducers (weak)
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cholestenes
    Drug Categories cholestanes
    Drug Categories cholecalciferol
    Drug Categories chemical actions and uses
    Drug Categories cardiovascular agents
    Drug Categories calcium channel agonists
    Drug Categories bone density conservation agents
    Drug Categories antipsoriatics for topical use
    Drug Categories antipsoriatics
    Drug Groups nutraceutical
    Drug Groups approved
    (11 More Sources)

    Publications:

    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Reinhart, 2004, Vitamin D analogs: novel therapeutic agents for cardiovascular disease?, Curr Opin Investig Drugs
    Glorieux et al., 2001, The anti-proliferative effect of calcitriol on HL-60 cells is neutralized by uraemic biological fluids., Nephrol. Dial. Transplant.
    Dossing et al., 2005, Receptor activator of NF-kappaB ligand protein expression in UMR-106 cells is differentially regulated by parathyroid hormone and calcitriol., J. Cell. Biochem.
    Nazarova et al., 2004, Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth., Int. J. Cancer
    Haq, 1986, 1,25-Dihydroxyvitamin D3 (calcitriol) suppresses IL-2 induced murine thymocyte proliferation., Thymus
    Beer et al., 2004, Randomized study of high-dose pulse calcitriol or placebo prior to radical prostatectomy., Cancer Epidemiol. Biomarkers Prev.
    Saunders et al., 1993, Inhibition of c-myc in breast and ovarian carcinoma cells by 1,25-dihydroxyvitamin D3, retinoic acid and dexamethasone., Anticancer Drugs
    Kruse et al., 1998, Calcium metabolism and growth during early treatment of children with X-linked hypophosphataemic rickets., Eur. J. Pediatr.
    Gyetko et al., 1988, Modulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-2 expression by U-937 mononuclear phagocytes. Effects of 1 alpha, 25-dihydroxyvitamin D3 and phorbol ester., J. Immunol.
    Dackiw et al., 2004, Vitamin D3 administration induces nuclear p27 accumulation, restores differentiation, and reduces tumor burden in a mouse model of metastatic follicular thyroid cancer., Endocrinology