DGIdb - BREXPIPRAZOLE Drug Record

BREXPIPRAZOLE CHEMBL2105760 FDA Approved

Alternate Names:

Brexpiprazole
OPC-34712
223366007
7672
7-[4-(4-BENZO[B]THIOPHEN-4-YL-PIPERAZIN-1-YL)BUTOXY]-1H-QUINOLIN-2-ONE
2(1H)-QUINOLINONE, 7-(4-(4-BENZO(B)THIEN-4-YL-1-PIPERAZINYL)BUTOXY)-
D10309
HY-15780
BC600277
AK171366
CS-2108
AKOS025291100
OPC 34712
OPC34712
ZKIAIYBUSXZPLP-UHFFFAOYSA-N
SCHEMBL14772509
BREXPIPRAZOLE (JAN/USAN/INN)
SCHEMBL1037592
GTPL7672
2J3YBM1K8C
REXULTI (TN)
7-{4-(4-(1-BENZOTHIOPHEN-4-YL)PIPERAZIN-1-YL)BUTOXY}QUINOLIN-2(1H)-ONE
7-(4-(4-(1-BENZOTHIOPHEN-4-YL)PIPERAZIN-1-YL)BUTOXY)QUINOLIN-2(1H)-ONE
7-[4-[4-(1-BENZOTHIOPHEN-4-YL)PIPERAZIN-1-YL]BUTOXY]-1H-QUINOLIN-2-ONE
7-(4-(4-(BENZO[B]THIOPHEN-4-YL)PIPERAZIN-1-YL)BUTOXY)QUINOLIN-2(1H)-ONE
BREXPIPRAZOLE {USAN]
BREXPIPRAZOLE [USAN]
UNII-2J3YBM1K8C
913611-97-9
11978813
Rexulti
DB09128

Drug Info:

Drug Categories	sulfur compounds
Drug Categories	serotonin agents
Drug Categories	quinolines
Drug Categories	psycholeptics
Drug Categories	physiological effects of drugs
Drug Categories	pharmacologic actions
Drug Categories	organic chemicals
Drug Categories	neurotransmitter agents
Drug Categories	nervous system
Drug Categories	molecular mechanisms of pharmacological action
Drug Categories	inorganic chemicals
Drug Categories	hyperglycemia-associated agents
Drug Categories	heterocyclic compounds, 2-ring
Drug Categories	heterocyclic compounds, 1-ring
Drug Categories	heterocyclic compounds
Drug Categories	dopamine agonists
Drug Categories	dopamine agents
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	chemical actions and uses
Drug Categories	central nervous system depressants
Drug Categories	antipsychotic agents
Drug Categories	alpha1 antagonists
Drug Groups	approved
Drug Type	small molecule
FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antidepressant

(2 More Sources)

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.
Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.

BREXPIPRAZOLE DRD2

Interaction Types:

partial agonist

agonist

Interaction Info:

Trial Name OPC-34712

Novel drug target Established target

Mechanism of Interaction Dopamine D2 receptor partial agonist

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.
BREXPIPRAZOLE HTR1A

Interaction Types:

partial agonist

agonist

Interaction Info:

Mechanism of Interaction Serotonin 1a (5-HT1a) receptor partial agonist

Direct Interaction yes

Trial Name OPC-34712

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.
BREXPIPRAZOLE HTR2A

Interaction Types:

antagonist

Interaction Info:

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Direct Interaction yes

Trial Name OPC-34712

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.
BREXPIPRAZOLE ADRA2C

Interaction Types:

antagonist

Interaction Info:

Publications:

Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.
BREXPIPRAZOLE ADRA1B

Interaction Types:

antagonist

Interaction Info:

Publications:

Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.
BREXPIPRAZOLE HTR7

Interaction Types:

n/a

Interaction Info:

Trial Name OPC-34712

Novel drug target Established target

Publications:
BREXPIPRAZOLE CYP2D6

Interaction Types:

n/a

Interaction Info:

Publications:

DrugBank: DB09128

Version: 5.0.8

Alternate Names:

BREXPIPRAZOLE DrugBank Drug Name

913611-97-9 CAS Number

Rexulti Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alpha1 antagonists

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.

Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.

TdgClinicalTrial: OPC-34712
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class small molecule

FDA Approval not approved

Publications:
PubChem: BREXPIPRAZOLE
- Version: 09-Feb-2016
Alternate Names:

BREXPIPRAZOLE pubchem_primary_name

11978813 PubChem CID

913611-97-9 Drug Synonym

Drug Info:

Publications:
GuideToPharmacologyInteractions: 7672
- Version: 27-September-2017
Alternate Names:

BREXPIPRAZOLE GuideToPharmacology Ligand Name

223366007 PubChem Drug SID

Drug Info:

Publications:
ChemblInteractions: CHEMBL2105760
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Brexpiprazole
- Version: 15-September-2017
Alternate Names:

Drug Info:

Publications:

Trial Name	OPC-34712
Novel drug target	Established target
Mechanism of Interaction	Dopamine D2 receptor partial agonist

Mechanism of Interaction	Serotonin 1a (5-HT1a) receptor partial agonist
Direct Interaction	yes
Trial Name	OPC-34712

Mechanism of Interaction	Serotonin 2a (5-HT2a) receptor antagonist
Direct Interaction	yes
Trial Name	OPC-34712

BREXPIPRAZOLE	DrugBank Drug Name
913611-97-9	CAS Number
Rexulti	Drug Brand

BREXPIPRAZOLE	pubchem_primary_name
11978813	PubChem CID
913611-97-9	Drug Synonym

BREXPIPRAZOLE	GuideToPharmacology Ligand Name
223366007	PubChem Drug SID

BREXPIPRAZOLE Drug Record

BREXPIPRAZOLE CHEMBL2105760 FDA Approved

Alternate Names:

Drug Info:

Publications:

BREXPIPRAZOLE DRD2

Interaction Types: partial agonist agonist

Interaction Info: Trial Name OPC-34712 Novel drug target Established target Mechanism of Interaction Dopamine D2 receptor partial agonist

Publications: Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.

BREXPIPRAZOLE HTR1A

Interaction Types: partial agonist agonist

Interaction Info: Mechanism of Interaction Serotonin 1a (5-HT1a) receptor partial agonist Direct Interaction yes Trial Name OPC-34712

Publications: Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.

BREXPIPRAZOLE HTR2A

Interaction Types: antagonist

Interaction Info: Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist Direct Interaction yes Trial Name OPC-34712

Publications: Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.

BREXPIPRAZOLE ADRA2C

Interaction Types: antagonist

Interaction Info:

Publications: Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.

BREXPIPRAZOLE ADRA1B

Interaction Types: antagonist

Interaction Info:

Publications: Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.

BREXPIPRAZOLE HTR7

Interaction Types: n/a

Interaction Info: Trial Name OPC-34712 Novel drug target Established target

Publications:

BREXPIPRAZOLE CYP2D6

Interaction Types: n/a

Interaction Info:

Publications:

DrugBank: DB09128

Alternate Names: BREXPIPRAZOLE DrugBank Drug Name 913611-97-9 CAS Number Rexulti Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories alpha1 antagonists

TdgClinicalTrial: OPC-34712

Alternate Names:

Drug Info: Drug Indications antidepressant Drug Class small molecule FDA Approval not approved

Publications:

PubChem: BREXPIPRAZOLE

Alternate Names: BREXPIPRAZOLE pubchem_primary_name 11978813 PubChem CID 913611-97-9 Drug Synonym

Drug Info:

Publications:

GuideToPharmacologyInteractions: 7672

Alternate Names: BREXPIPRAZOLE GuideToPharmacology Ligand Name 223366007 PubChem Drug SID

Drug Info:

Publications:

ChemblInteractions: CHEMBL2105760

Alternate Names:

Drug Info:

Publications:

FDA: Brexpiprazole

Alternate Names:

Drug Info:

Publications:

Interaction Types:

partial agonist

agonist

Interaction Info:

Trial Name OPC-34712

Novel drug target Established target

Mechanism of Interaction Dopamine D2 receptor partial agonist

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.

Interaction Types:

partial agonist

agonist

Interaction Info:

Mechanism of Interaction Serotonin 1a (5-HT1a) receptor partial agonist

Direct Interaction yes

Trial Name OPC-34712

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.

Interaction Types:

antagonist

Interaction Info:

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Direct Interaction yes

Trial Name OPC-34712

Publications:

Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.

Interaction Types:

antagonist

Publications:

Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.

Interaction Types:

antagonist

Publications:

Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.

Interaction Types:

n/a

Interaction Info:

Trial Name OPC-34712

Novel drug target Established target

Interaction Types:

n/a

Alternate Names:

BREXPIPRAZOLE DrugBank Drug Name

913611-97-9 CAS Number

Rexulti Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alpha1 antagonists

Drug Info:

Drug Indications antidepressant

Drug Class small molecule

FDA Approval not approved

Alternate Names:

BREXPIPRAZOLE pubchem_primary_name

11978813 PubChem CID

913611-97-9 Drug Synonym

Alternate Names:

BREXPIPRAZOLE GuideToPharmacology Ligand Name

223366007 PubChem Drug SID