• ASTEMIZOLE CHEMBL296419

    Alternate Names:

    Astemizole
    Pollon-Eze
    R-43512
    Hismanal
    GNF-Pf-2461
    Stemiz
    Lergibrumizol
    Histalong
    Hismanal Tab 10mg
    Hismanal Suspension 2mg/ml
    Hismanal - Tab 10mg
    Astesen
    Alerkin
    Acemiz
    68844-77-9
    Astemison
    1-(P-Fluorobenzyl)-2-((1-(P-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
    1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole
    DB00637
    PARALERGIN
    C06832
    HISTAMINOS
    NONO-NASTIZOL A
    24226
    2896
    KELP
    ASTEMISAN
    2247
    D00234
    46508569
    2160
    LARIDAL
    WARUZOL
    COC1CCC(CC1)CCN2CCC(CC2)NC3NC4CCCCC4N3CC5CCC(CC5)F
    PA448498
    RETOLEN
    ASTEMISOL
    HISTAMEN
    METODIK
    DAP000326
    HISTAZOL
    ALERMIZOL
    2182912
    2603
    188751
    135649968
    1H-BENZIMIDAZOL-2-AMINE,1-((4-FLUOROPHENYL)METHYL)-N-(1-(2-(4-METHOXYPHENYL)ETHYL)-4-PIPERDINYL)
    1-[(FLUOROPHENYL)-METHYL]-N-[1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDINYL]-1H-BENZIMIDAZOL-2-AMINE
    1-[(4-FLUOROPHENYL)METHYL]-N-{1-[2-(4-METHOXYPHENYL)ETHYL]PIPERIDIN-4-YL}-1H-1,3-BENZODIAZOL-2-AMINE
    1-(4-FLUOROPHENYLMETHYL)-N-{1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDINYL}-1H-BENZIMIDAZOL-2-AMINE
    1-(4-FLUOROBENZYL)-N-(1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDINYL)-1H-BENZIMIDAZOL-2-AMINE #
    CID_2247
    NCHEMBIO806-COMP1
    NCHEMBIO732-COMP2
    CID2247
    1-(P-FLUOROBENZYL)-2-[[1-(P-METHOXYPHENETHYL)-4-PIPERIDYL]AMINO]BENZIMIDAZOLE
    NOVO-NASTIZOL A
    REIG JOFRE BRAND OF ASTEMIZOLE
    RATIOPHARM BRAND OF ASTEMIZOLE
    SENOSIAIN BRAND OF ASTEMIZOLE
    HISMANALREG
    SMALLER BRAND OF ASTEMIZOLE
    MEDINSA BRAND OF ASTEMIZOLE
    JANSSEN BRAND OF ASTEMIZOLE
    FUSTERY BRAND OF ASTEMIZOLE
    MCNEIL BRAND OF ASTEMIZOLE
    URBION BRAND OF ASTEMIZOLE
    ESTEVE BRAND OF ASTEMIZOLE
    ASTEMIZOLE RATIOPHARM BRAND
    ALONGA BRAND OF ASTEMIZOLE
    ALACAN BRAND OF ASTEMIZOLE
    ASTEMIZOLE SENOSIAIN BRAND
    SEPTA BRAND OF ASTEMIZOLE
    MERCK BRAND OF ASTEMIZOLE
    LESVI BRAND OF ASTEMIZOLE
    ELFAR BRAND OF ASTEMIZOLE
    VITA BRAND OF ASTEMIZOLE
    DIBA BRAND OF ASTEMIZOLE
    ICN BRAND OF ASTEMIZOLE
    BYK BRAND OF ASTEMIZOLE
    ASTEMIZOLE SMALLER BRAND
    ASTEMIZOLE MEDINSA BRAND
    ASTEMIZOLE JANSSEN BRAND
    ASTEMIZOLE FUSTERY BRAND
    ASTEMIZOLE MCNEIL BRAND
    ASTEMIZOLE URBION BRAND
    ASTEMIZOLE ESTEVE BRAND
    ASTEMIZOLE ALONGA BRAND
    ASTEMIZOLE ALACAN BRAND
    ASTEMIZOLE SEPTA BRAND
    ASTEMIZOLE MERCK BRAND
    ASTEMIZOLE LESVI BRAND
    ASTEMIZOLE ELFAR BRAND
    ASTEMIZOLE VITA BRAND
    ASTEMIZOLE ICN BRAND
    ASTEMIZOLE DIBA BRAND
    RATIOPHARM, ASTEMIZOL
    ASTEMIZOLE BYK BRAND
    ASTEMIZOL RATIOPHARM
    1H-BENZIMIDAZOL-2-AMINE, 1-[(4-FLUOROPHENYL)METHYL]-N-[1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDINYL]-
    1H-BENZIMIDAZOL-2-AMINE, 1-((4-FLUOROPHENYL)METHYL)-N-(1-(2-(4-METHOXYPHENYL)ETH L)-4-PIPERIDINYL)-
    1-[(4-FLUOROPHENYL)METHYL]-N-[1-[2-(4-METHOXYPHENYL)ETHYL]PIPERIDIN-4-YL]BENZIMIDAZOL-2-AMINE
    1-[(4-FLUOROPHENYL)METHYL]-N-(1-{2-[4-(METHYLOXY)PHENYL]ETHYL}PIPERIDIN-4-YL)-1H-BENZIMIDAZOL-2-AMINE
    1-((4-FLUOROPHENYL)METHYL)-N-(1-(2-(4-METHOXYPHENYL)ETHYL)-4-PIPERIDINYL)- 1H-BENZIMIDAZOL-2-AMINE
    1-[(4-FLUOROPHENYL)METHYL]-N-[1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDYL]BENZIMIDAZOL-2-AMINE
    1-(4-FLUOROBENZYL)-N-{1-[2-(4-METHOXYPHENYL)ETHYL]PIPERIDIN-4-YL}-1H-BENZIMIDAZOL-2-AMINE
    ALONGA, ASTEMIZOL
    HESTAZOL, KELP, LARIDAL, RETOLEN, WAREEZOL, HSBD 6799, BRN 4830190
    ASTEMIZOL ALONGA
    URDRIM
    RIMBOL
    EMDAR
    SIMPROX
    ROMADIN
    RIFEDOT
    ESMACEN
    ASTEMINA
    HUBERMIZOL
    FUSTERMIZOL
    BRD-K37249724-001-05-9
    1H-BENZIMIDAZOL-2-AMINE, 1-((4-FLUOROPHENYL)METHYL)-N-(1-(2-(4-METHOXYPHENYL)ETHYL)-4-PIPERIDINYL)-
    L001015
    DSSTOX_GSID_20110
    DSSTOX_RID_75373
    BENZIMIDAZOLE, 1-(P-FLUOROBENZYL)-2-((1-(2-(P-METHOXYPHENYL)ETHYL)PIPERID-4-YL)AMINO)-
    AB00052413
    DSSTOX_CID_110
    SMR000058911
    LS-32978
    NCGC00022520-07
    NCGC00022520-06
    NCGC00022520-05
    NCGC00022520-04
    NCGC00022520-03
    NCGC00018288-01
    NCGC00016913-08
    NCGC00016913-01
    QTL1_000010
    IDI1_000039
    1-[(4-FLUOROPHENYL)METHYL]-N-[1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDINYL]-1H-BENZIMIDAZOL-2-AMINE
    AKOS005064371
    NSC329963
    UNII-7HU6337315
    HMS2093L18
    HMS2090F14
    HMS1922L12
    HMS1568K14
    GXDALQBWZGODGZ-UHFFFAOYSA-N
    NINDS_000039
    KBIO3_001904
    KBIO2_006064
    KBIO2_003496
    KBIO2_000928
    KBIO1_000039
    HMS500B21
    UPCMLD-DP024:001
    ST51014896
    BPBIO1_000234
    MJD-30
    AC1L1D93
    MLS001148073
    MLS000028667
    CAS-68844-77-9
    SPECTRUM2300094
    SPBIO_002151
    SPBIO_001804
    ASTEMIZOLE [USAN:BAN:INN]
    DIVK1C_000039
    KBIOSS_000928
    KBIOGR_001686
    BSPBIO_002684
    BSPBIO_000212
    ASTEMIZOLE (JAN/USP/INN)
    BRN 4830190
    UPCMLD-DP024
    R 42512
    {1-[(4-FLUOROPHENYL)METHYL]BENZIMIDAZOL-2-YL}{1-[2-(4-METHOXYPHENYL)ETHYL](4-P IPERIDYL)}AMINE
    1-(4-FLUOROBENZYL)-N-(1-(4-METHOXYPHENETHYL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOL-2-AMINE
    1-(4-FLUOROBENZYL)-2-(1-[4-METHOXYPHENETHYL]PIPERIDIN-4-YL)AMINOBENZIMIDAZOLE
    W-104654
    5318-EP2371811A2
    5318-EP2314590A1
    5318-EP2311827A1
    5318-EP2308562A2
    5318-EP2305659A1
    5318-EP2305640A2
    5318-EP2301933A1
    5318-EP2295409A1
    5318-EP2292619A1
    5318-EP2292617A1
    5318-EP2281815A1
    5318-EP2270008A1
    FT-0662309
    FT-0622497
    AB00052413-18
    7HU6337315
    K146
    HE379960
    HE069273
    BC218650
    AN-38015
    AK117716
    AJ-23671
    NCGC00257649-01
    NCGC00016913-14
    NCGC00016913-12
    NCGC00016913-11
    NCGC00016913-10
    NCGC00016913-09
    NCGC00016913-07
    NCGC00016913-06
    NCGC00016913-05
    NCGC00016913-04
    NCGC00016913-03
    NCGC00016913-02
    NSC-759570
    NSC-329963
    MCULE-9080712110
    KS-5171
    TOX21_110680_1
    STL301859
    NSC759570
    CCG-39453
    TOX21_200095
    TOX21_110680
    ZINC601274
    PHARMAKON1600-02300094
    HMS3373B08
    HMS2234M17
    HMS2095K14
    MOLPORT-003-666-765
    CTK8F7845
    BDBM24226
    GTPL2603
    ASTEMIZOLE, [O-METHYL-3H]
    REGID_FOR_CID_2247
    D016589
    SCHEMBL4385
    EINECS 272-441-9
    SPECTRUM5_001239
    SPECTRUM4_001223
    SPECTRUM3_001072
    SPECTRUM2_001732
    PRESTWICK3_000136
    PRESTWICK2_000136
    PRESTWICK1_000136
    PRESTWICK0_000136
    HISMANAL (TN)
    SPECTRUM_000448
    HSDB 6799
    CHEBI:2896
    CCRIS 7595
    C28H31FN4O
    PRESTWICK_35
    [3H]ASTEMIZOLE
    ASTEMIZOLUM [INN-LATIN]
    ASTEMIZOL [INN-SPANISH]
    ASTEMIZOL [GERMAN]
    NOVO-MASTIZOL A
    WAREEZOL
    METODIH
    HESTAZOL
    ASTEMIZOLUM
    ASTEMIZOL
    135650470
    L-367,938

    Drug Info:

    Drug Categories therapeutic uses
    Drug Categories respiratory system
    Drug Categories physiological effects of drugs
    Drug Categories pharmacologic actions
    Drug Categories p-glycoprotein/abcb1 inhibitors
    Drug Categories neurotransmitter agents
    Drug Categories molecular mechanisms of pharmacological action
    Drug Categories histamine h1 antagonists, non-sedating
    Drug Categories histamine h1 antagonists
    Drug Categories histamine antagonists
    Drug Categories histamine agents
    Drug Categories heterocyclic compounds, 2-ring
    Drug Categories heterocyclic compounds
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a inhibitors
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories combined inhibitors of cyp3a4 and p-glycoprotein
    Drug Categories chemical actions and uses
    Drug Categories benzimidazoles
    Drug Categories antihistamines for systemic use
    Drug Categories anti-allergic agents
    Drug Groups withdrawn
    Drug Groups approved
    Drug Type small molecule
    Year of Approval 1988
    Drug Class anti-allergic agents
    ATC r06ax(other antihistamines for systemic use)
    Drug Type drug/small molecule
    FDA Approval 1988
    Drug Class small molecule
    Drug Indications Anti-Allergic Agents
    (5 More Sources)

    Publications:

    Cavero et al., 1999, Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?, Drug Saf
    Richards et al., 1984, Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy., Drugs
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kaliner et al., Non-sedating antihistamines., Allergy Proc
    Salata et al., 1995, Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine., Circ. Res.
    Llenas et al., 1999, Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines., Drug Saf
    Krstenansky et al., 1987, Astemizole: a long-acting, nonsedating antihistamine., Drug Intell Clin Pharm
    Howarth et al., 1984, Astemizole, a potent histamine H1-receptor antagonist: effect in allergic rhinoconjunctivitis, on antigen and histamine induced skin weal responses and relationship to serum levels., Br J Clin Pharmacol
    Chiu et al., 2004, Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels., J. Pharmacol. Sci.
    Chachin et al., 1999, Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel., Eur. J. Pharmacol.
    Grzelewska-Rzymowska et al., 2001, [The effect of second generation histamine antagonists on the heart]., Pneumonol Alergol Pol
    Taglialatela et al., 1999, Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity., Clin. Exp. Allergy
    Zhou et al., 1999, Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole., J. Cardiovasc. Electrophysiol.